Selective Insulin Resistance in the Polycystic Ovary Syndrome¹

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*

1997 • 2,442 citations

Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

1989 • 1,858 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women¹

1999 • 1,571 citations

Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study¹

1998 • 1,550 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

1992 • 908 citations

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1999 • 867 citations

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome

1998 • 689 citations

A Fasting Glucose to Insulin Ratio Is a Useful Measure of Insulin Sensitivity in Women with Polycystic Ovary Syndrome¹

1998 • 688 citations

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

1997 • 654 citations

Insulin Stimulates Androgen Accumulation in Incubations of Ovarian Stroma Obtained from Women with Hyperandrogenism*

1986 • 629 citations

Characterization of Groups of Hyperaiidrogenic Women with Acanthosis Nigricans, Impaired Glucose Tolerance, and/or Hyperinsulinemia*

1987 • 590 citations

Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System¹

1998 • 571 citations

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

1995 • 549 citations

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

1996 • 538 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome

1992 • 511 citations

Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.

1996 • 423 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Suppression of Serum Insulin by Diazoxide Reduces Serum Testosterone Levels in Obese Women with Polycystic Ovary Syndrome*

1989 • 345 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Insulin-like growth factors and insulin: comparative aspects

1985 • 262 citations

Insulin Action and Glucose Metabolism in Nondiabetic Control and NIDDM Subjects: Comparison Using Human Skeletal Muscle Cell Cultures

1995 • 220 citations

Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes

1993 • 216 citations

Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor.

1995 • 198 citations

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

1988 • 195 citations

Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling?

1996 • 169 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

1996 • 132 citations

Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.

1991 • 123 citations

Impaired Adipocyte Lipolysis in Nonobese Women with the Polycystic Ovary Syndrome: A Possible Link to Insulin Resistance?¹

1997 • 110 citations

Specificity Spillover at the Hormone Receptor — Exploring Its Role in Human Disease

1989 • 89 citations

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

1991 • 82 citations

Evaluation of WHO and NDDG Criteria for Impaired Glucose Tolerance: Results From Two National Samples

1989 • 81 citations

Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.

1995 • 81 citations

In vivo insulin action and muscle glycogen synthase activity in Type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment

1992 • 77 citations

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

1993 • 77 citations

Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome

1994 • 66 citations

Acquired Defects of Glycogen Synthase Activity in Cultured Human Skeletal Muscle Cells: Influence of High Glucose and Insulin Levels

1996 • 59 citations

Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.

1998 • 54 citations

Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects

1981 • 48 citations

Abnormal Activation of Glycogen Synthesis in Fibroblasts from NIDDM Subjects: Evidence for an Abnormality Specific to Glucose Metabolism

1993 • 44 citations

Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

1996 • 42 citations

Evaluation of WHO and NDDG criteria for impaired glucose tolerance

1994 • 34 citations

Glucose and Insulin Regulate Insulin Sensitivity in Primary Cultured Adipocytes without Affecting Insulin Receptor Kinase Activity*

1991 • 33 citations

Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome

1998 • 30 citations

Enzymatic Activities of P450c17 Stably Expressed in Fibroblasts from Patients with the Polycystic Ovary Syndrome¹

2000 • 27 citations

Clarification of Signaling Pathways Mediated by Insulin and Insulin-Like Growth Factor I Receptors in Fibroblasts From Patients With Specific Defect in Insulin Receptor

1988 • 23 citations

Insulin Activates Glycogen Synthase in Cultured Human Fibroblasts

1980 • 16 citations

Autophosphorylation of Cultured Skin Fibroblast Insulin Receptors From Patients With Severe Insulin Resistance and Acanthosis Nigricans

1989 • 10 citations

Decline in Insulin-Like Growth Factor I Levels after Clomiphene Citrate Does Not Correct Hyperandrogenemia in Polycystic Ovary Syndrome

1998 • 9 citations

Rat fibroblast cells overexpressing kinase-inactive human insulin receptors are insulin responsive: influence of growth conditions.

1995 • 6 citations