Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment.

SYNTHESIS OF THE CARBOHYDRATE OF MUCUS IN THE GOLGI COMPLEX AS SHOWN BY ELECTRON MICROSCOPE RADIOAUTOGRAPHY OF GOBLET CELLS FROM RATS INJECTED WITH GLUCOSE-H3

1966 • 529 citations

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

1991 • 457 citations

Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates

1983 • 436 citations

Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.

1985 • 415 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

1986 • 331 citations

Macro- and Micro-Domains in the Endocrine Pancreas

1982 • 306 citations

Direct identification of prohormone conversion site in insulin-secreting cells

1985 • 297 citations

Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood

1969 • 294 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Characterization of the immature secretory granule, an intermediate in granule biogenesis.

1991 • 231 citations

CONDENSING VACUOLE CONVERSION AND ZYMOGEN GRANULE DISCHARGE IN PANCREATIC EXOCRINE CELLS: METABOLIC STUDIES

1971 • 226 citations

Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells.

1986 • 220 citations

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.

1987 • 204 citations

RADIOAUTOGRAPHIC ANALYSIS OF THE SECRETORY PROCESS IN THE PAROTID ACINAR CELL OF THE RABBIT

1972 • 204 citations

Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells

1983 • 198 citations

The insulin secretory granule

1989 • 188 citations

Proteolytic Processing of Pro-ACTH/Endorphin Begins in the Golgi Complex of Pituitary Corticotropes and AtT-20 Cells

1989 • 165 citations

Protein discharge from immature secretory granules displays both regulated and constitutive characteristics

1991 • 139 citations

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

1988 • 135 citations

Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas.

1987 • 110 citations

C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.

1984 • 105 citations

Studies on the molecular organization of rat insulin secretory granules.

1987 • 95 citations

An antibody specific for an endoproteolytic cleavage site provides evidence that pro-opiomelanocortin is packaged into secretory granules in AtT20 cells before its cleavage.

1987 • 90 citations

The Role of Secretory Granules in Peptide Biosynthesisa

1987 • 72 citations

Efficient targeting to storage granules of human proinsulins with altered propeptide domain.

1988 • 64 citations

Secretion of old versus new exportable protein in rat parotid slics. Control by neurotransmitters.

1976 • 61 citations

A trans Golgi-derived exocytic coated vesicle can contain both newly synthesized cholinesterase and internalized transferrin

1987 • 60 citations

High resolution analysis of the secretory pathway in mammotrophs of the rat anterior pituitary.

1981 • 58 citations

Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment.

1984 • 55 citations

Secretion of digestive enzyme derived from two parallel intracellular pools

1974 • 52 citations

Inhibition of islet prohormone to hormone conversion by incorporation of arginine and lysine analogs.

1981 • 51 citations

Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.

1991 • 51 citations

Ammonium Chloride Alters Secretory Protein Sorting within the Maturing Exocrine Storage Compartment

1989 • 41 citations

Regulated and constitutive protein targeting can be distinguished by secretory polarity in thyroid epithelial cells.

1991 • 38 citations

A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.

1986 • 36 citations

Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products.

1982 • 30 citations

Newly synthesized secretory proteins from pig pancreas are not released from a homogeneous granule compartment

1982 • 29 citations

Constitutive protein secretion from the exocrine pancreas of fetal rats.

1987 • 26 citations

The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide

1988 • 23 citations

Nonparallel transport of exportable proteins in rat pancreas in vitro

1982 • 9 citations

Release of Newly Synthesized Hormone from the Pancreatic Beta Cell

1984 • 6 citations

Preparation of β-cells from fetal bovine pancreas: characterization of insulin biosynthetic activity

1979 • 5 citations

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