Is a sorting signal necessary to package proteins into secretory granules?

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.

1981 • 990 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Comparative studies of intracellular transport of secretory proteins.

1978 • 452 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

Induction of specific storage organelles by von Willebrand factor propolypeptide

1991 • 276 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells

1983 • 198 citations

Multiple neuropeptides derived from a common precursor are differentially packaged and transported

1988 • 196 citations

Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells.

1987 • 156 citations

Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells.

1989 • 154 citations

Intracellular Transport and Packaging of Prolactin: A Quantitative Electron Microscope Autoradiographic Study of Mammotrophs Dissociated from Rat Pituitaries*

1978 • 154 citations

Secretory protein targeting in a pituitary cell line: differential transport of foreign secretory proteins to distinct secretory pathways.

1985 • 145 citations

The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells.

1989 • 138 citations

Re-routing of a secretory protein by fusion with human growth hormone sequences

1986 • 138 citations

In cow anterior pituitary, growth hormone and prolactin can be packed in separate granules of the same cell.

1985 • 130 citations

Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

1990 • 127 citations

Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules.

1987 • 119 citations

Sorting of three secretory proteins to distinct secretory granules in acidophilic cells of cow anterior pituitary.

1987 • 117 citations

An antibody against secretogranin I (chromogranin B) is packaged into secretory granules.

1989 • 116 citations

Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity

1989 • 108 citations

Peptide Processing and Targeting in the Neuronal Secretory Pathway

1991 • 107 citations

Hormonal Induction of Secretory Granules in a Pituitary Tumor Cell Line*

1986 • 107 citations

Studies on the molecular organization of rat insulin secretory granules.

1987 • 95 citations

The role of a low pH intracellular compartment in the processing, storage, and secretion of ACTH and endorphin.

1988 • 86 citations

Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells.

1987 • 84 citations

The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer.

1985 • 82 citations

Cytological Factors that Support Nonparallel Secretion of Luteinizing Hormone and Follicle-Stimulating Hormone during the Estrous Cycle*

1987 • 71 citations

A subclass of proteins and sulfated macromolecules secreted by AtT-20 (mouse pituitary tumor) cells is sorted with adrenocorticotropin into dense secretory granules.

1983 • 69 citations

Co-localization of secretogranins/chromogranins with thyrotropin and luteinizing hormone in secretory granules of cow anterior pituitary.

1990 • 56 citations

In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules.

1987 • 54 citations

Ultrastructural immunocytochemical localization of LH and FSH in the pituitary of the untreated male rat

1984 • 53 citations

Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 pituitary cells.

1988 • 47 citations

Regulation of chromogranin B/secretogranin I and secretogranin II storage in GH4C1 cells.

1990 • 29 citations

Comparison of the Regulation of Carboxypeptidase E and Prolactin in GH<sub>4</sub>C<sub>1</sub> Cells, a Rat Pituitary Cell Line

1990 • 28 citations

Prolactin and Insulin Are Targeted to the Regulated Pathway in GH₄C₁Cells, but Their Storage Is Differentially Regulated

1990 • 27 citations

Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans

1989 • 26 citations

Large dense cored vesicles are enriched in neuropeptide processing intermediates in the Aplysia bag cells

1989 • 6 citations