Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors.

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal

1996 • 717 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Biological behavior of malignant melanoma cells correlated to their survival in vivo.

1975 • 586 citations

NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation.

1989 • 340 citations

Characteristics of cultured human melanocytes isolated from different stages of tumor progression.

1985 • 264 citations

Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

1992 • 222 citations

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

1990 • 211 citations

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

1996 • 193 citations

Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression

1995 • 183 citations

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.

1995 • 170 citations

The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice

1996 • 169 citations

The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements

1989 • 164 citations

Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter

1993 • 141 citations

Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene.

1986 • 137 citations

Cell Type-specific Induction of the Major Immediate Early Enhancer of Human Cytomegalovirus by Cyclic AMP

1990 • 122 citations

[2] Techniques for human adenovirus vector construction and characterization

1995 • 118 citations

Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12

1996 • 111 citations

Differences in Cell Type-specific Blocks to Immediate Early Gene Expression and DNA Replication of Human, Simian and Murine Cytomegalovirus

1988 • 109 citations

Transcriptional regulation of the human cytomegalovirus major immediate-early gene is associated with induction of DNase I-hypersensitive sites.

1986 • 92 citations

Developmental analysis of the cytomegalovirus enhancer in transgenic animals

1996 • 75 citations

Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro.

1988 • 56 citations

The Role of a Repetitive Palindromic Sequence Element in the Human Cytomegalovirus Major Immediate Early Enhancer

1989 • 52 citations

Unusual cell specific expression of a major human cytomegalovirus immediate early gene promoter-lacZ hybrid gene in transgenic mouse embryos

1991 • 38 citations

Formation of several specific nucleoprotein complexes on the human cytomegalovirus immediate early enhancer

1991 • 36 citations

AN ADENOVIRAL VECTOR EXPRESSING INTERLEUKIN-4 MODULATES TUMORIGENICITY AND INDUCES REGRESSION IN A MURINE BREAST-CANCER MODEL

1995 • 27 citations

Investigation of promoter function in human and animal cells infected with human recombinant adenoviruses expressing rotavirus antigen VP7sc

1995 • 24 citations

Construction and Characterization of Recombinant Human Adenovirus Type 5 Vectors

1995 • 1 citations