Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy

1998 • 973 citations

The molecular biology of apoptosis.

1996 • 963 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

1997 • 719 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

The molecular biology of apoptoseis.

1996 • 390 citations

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

1995 • 374 citations

Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase

1998 • 354 citations

The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

1997 • 344 citations

A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function.

1995 • 325 citations

Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

1999 • 307 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

1994 • 246 citations

Involvement of caspase-dependent activation of cytosolic phospholipase A₂in tumor necrosis factor-induced apoptosis

1997 • 207 citations

Epidermal Growth Factor Receptor Family and Chemosensitization

1997 • 176 citations

The MTT assay underestimates the growth inhibitory effects of interferons

1989 • 175 citations

The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-α, Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4

1996 • 167 citations

Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.

1998 • 166 citations

ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network

1998 • 141 citations

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.

1988 • 133 citations

C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators

1996 • 128 citations

The type I growth factor receptors in human breast cancer

1994 • 127 citations

Neu differentiation factor induces ErbB2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells.

1997 • 116 citations

Epidermal growth factor-related peptides in the pathogenesis of human breast cancer

1994 • 111 citations

Epidermal growth factor receptor monoclonal antibody inhibits constitutive receptor phosphorylation, reduces autonomous growth, and sensitizes androgen-independent prostatic carcinoma cells to tumor necrosis factor alpha.

1992 • 80 citations

Resistance of human ovarian cancer cells to tumor necrosis factor and lymphokine-activated killer cells: correlation with expression of HER2/neu oncogenes.

1990 • 63 citations

Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor

1995 • 59 citations

Interphase cytogenetic analysis of erbB2 and topollα co‐amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ

1995 • 56 citations

High-frequency transformation of human repair-deficient cell lines by an Epstein-Barr virus-based cDNA expression vector

1991 • 55 citations

Induction of sensitivity to doxorubicin and etoposide by transfection of MCF-7 breast cancer cells with heregulin beta-2.

1998 • 47 citations

Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family

1999 • 47 citations

Heregulin Activation of Extracellular Acidification in Mammary Carcinoma Cells Is Associated with Expression of HER2 and HER3

1995 • 47 citations

Resistance of tumor cells to tumor necrosis factor

1988 • 45 citations

Type 1 protein tyrosine kinases in benign and malignant breast lesions

1998 • 29 citations

Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis.

1996 • 26 citations

Activation of EGF receptor family members suppresses the cytotoxic effects of tumor necrosis factor-α

1998 • 25 citations

Heregulin induces increase in sensitivity of an erbB-2-overexpressing breast cancer cell type to lysis by lymphokine-activated killer cells

1996 • 4 citations