Species-Independent Inhibition of Abnormal Prion Protein (PrP) Formation by a Peptide Containing a Conserved PrP Sequence

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

1991 • 871 citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 • 812 citations

Normal host prion protein necessary for scrapie-induced neurotoxicity

1996 • 791 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease

1991 • 543 citations

ENCEPHALOPATHY IN MICE PRODUCED BY INOCULATION WITH SCRAPIE BRAIN MATERIAL

1961 • 505 citations

PrP Genotype and Agent Effects in Scrapie: Change In Allelic Interaction With Different Isolates of Agent in Sheep, a Natural Host of Scrapie

1994 • 440 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

A kinetic model for amyloid formation in the prion diseases: importance of seeding.

1993 • 391 citations

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

1991 • 385 citations

Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.

1993 • 369 citations

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

1995 • 343 citations

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes

1993 • 331 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Molecular assessment of the potential transmissibilities of BSE and scrapie to humans

1997 • 260 citations

Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

1978 • 250 citations

Prion diseases of humans and animals

1996 • 238 citations

The Genomic Identity of Different Strains of Mouse Scrapie Is Expressed in Hamsters and Preserved on Reisolation in Mice

1989 • 222 citations

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

1997 • 212 citations

Characterization of Scrapie Infection in Mouse Neuroblastoma Cells

1987 • 199 citations

Specific Inhibition of in Vitro Formation of Protease-resistant Prion Protein by Synthetic Peptides

1998 • 179 citations

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

1986 • 176 citations

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms

1997 • 174 citations

Prion protein and the transmissible spongiform encephalopathies

1997 • 168 citations

The association of a codon 136 PrP gene variant with the occurrence of natural scrapie

1994 • 158 citations

Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells

1994 • 156 citations

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent

1995 • 155 citations

A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells

1995 • 142 citations

Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.

1986 • 126 citations

Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones

1988 • 115 citations

Identification of cellular proteins binding to the scrapie prion protein

1990 • 98 citations

Characterization of Scrapie Agent Isolated from Sheep in Japan

1985 • 44 citations

Protease-resistant PrP accumulation and scrapie agent replication: a role for sulphated glycosaminoglycans?

1994 • 12 citations