Genetic Epidemiology of Parkinson's Disease

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

1992 • 9,892 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

A Clinicopathologic Study of 100 Cases of Parkinson's Disease

1993 • 950 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

1996 • 759 citations

A Manual of Diseases of the Nervous System.

1892 • 704 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

EPIDEMIOLOGY OF PARKINSON'S DISEASE

1996 • 631 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference

1997 • 626 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

1998 • 461 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

1997 • 372 citations

A Manual of Diseases of the Nervous System

1888 • 354 citations

Parkinson's disease in 65 pairs of twins and in a set of quadruplets

1983 • 353 citations

Apolipoprotein E: an important gene and protein to follow in laboratory medicine

1995 • 352 citations

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

1995 • 337 citations

Parkinson's disease

1993 • 281 citations

Risk of Parkinson's disease among first-degree relatives

1996 • 252 citations

Prevalence of Parkinson's disease in the biracial population of Copiah County, Mississippi

1985 • 246 citations

Clinical genetic analysis of Parkinson's disease in the contursi kindred

1996 • 238 citations

Environmental antecedents of young‐onset Parkinson's disease

1993 • 231 citations

Mutant debrisoquine hydroxylation genes in Parkinson's disease

1992 • 230 citations

ECOGENETICS OF PARKINSON'S DISEASE: 4-HYDROXYLATION OF DEBRISOQUINE

1985 • 228 citations

Increased risk of Parkinson's disease in parents and siblings of patients

1994 • 215 citations

Parkinson's disease in twins studied with ¹⁸ F‐dopa and positron emission tomography

1992 • 198 citations

Genetic dissection of Alzheimer disease, a heterogeneous disorder.

1995 • 179 citations

Association of a monoamine oxidase B allele with Parkinson's disease

1993 • 163 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy

1996 • 152 citations

Mitochondrial disease associated with the T8993G mutation of the mitochondrial ATPase 6 gene: a clinical, biochemical, and molecular study in six families

1997 • 149 citations

A clinical genetic study of Parkinson's disease

1994 • 140 citations

Low frequency of α‐synuclein mutations in familial Parkinson's disease

1998 • 137 citations

Parkinson's disease in a nationwide twin cohort

1988 • 135 citations

A clinical and genetic study of familial Parkinson's disease

1991 • 134 citations

Coiled Bodies and Gems: Janus or Gemini?

1998 • 134 citations

Autosomal dominant Lewy body parkinsonism in a four‐generation family

1994 • 131 citations

Twin studies and the genetics of Parkinson's disease—a reappraisal

1990 • 129 citations

High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease

1997 • 128 citations

Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.

1994 • 126 citations

Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

1997 • 120 citations

Epidemiology of Parkinson’s Disease

1992 • 118 citations

Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD)

1998 • 116 citations

The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis

1997 • 114 citations

Familial Parkinson’s Disease: A Clinical Genetic Analysis

1995 • 109 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1995 • 100 citations

The apolipoprotein ϵ4 allele in Parkinson's disease with and without dementia

1994 • 99 citations

Association of a polymorphism in the dopamine‐transporter gene with parkinson's disease

1997 • 96 citations

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

1998 • 96 citations

Maternal inheritance in Parkinson's disease

1997 • 95 citations

Failure to find the a‐synuclein gene missense mutation (G ²⁰⁹ A) in 100 patients with younger onset Parkinson's disease

1998 • 95 citations

The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease

1995 • 90 citations

Apolipoprotein E genotypes in Parkinson's disease with and without dementia

1995 • 89 citations

An allelic association study of monoamine oxidase B in parkinson's disease

1995 • 88 citations

A Greek‐American kindred with autosomal dominant, levodopa‐responsive parkinsonism and anticipation

1995 • 86 citations

Differential effects of acute and chronic nicotine treatment on MPTP-(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced degeneration of nigrostriatal dopamine neurons in the black mouse

1992 • 85 citations

No Association between Parkinson's Disease and Low-Activity Alleles of CatecholO-Methyltransferase

1996 • 84 citations

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease

1997 • 80 citations

Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease

1998 • 74 citations

Familial Parkinson's Disease: Possible Role of Environmental Factors

1987 • 74 citations

Variant cytochrome P₄₅₀ CYP2D6 allelic frequencies in Parkinson's disease

1993 • 73 citations

Chromosome 6–Linked Autosomal Recessive Early-Onset Parkinsonism: Linkage in European and Algerian Families, Extension of the Clinical Spectrum, and Evidence of a Small Homozygous Deletion in One Family

1998 • 73 citations

Absence of mutations in the coding region of the α-synuclein gene in pathologically proven Parkinson's disease

1998 • 72 citations

Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease

1994 • 72 citations

Parkinson's disease in twins

1992 • 71 citations

Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

1994 • 70 citations

Extrapyramidalism in Alzheimer's disease: prevalence, psychiatric, and neuropsychological correlates.

1994 • 69 citations

Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

1997 • 69 citations

Risk factors for nursing home placement in advanced Parkinson's disease

1993 • 67 citations

An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism

1993 • 66 citations

Familial Subsets in Idiopathic Parkinson’s Disease

1984 • 63 citations

Autosomal Recessive Juvenile Parkinsonism Maps to 6q25.2-q27 in Four Ethnic Groups: Detailed Genetic Mapping of the Linked Region

1998 • 61 citations

Association between the oxidative polymorphism and early onset of Parkinson's disease*

1995 • 61 citations

Senile dementia of the Lewy body type has an apolipoprotein E ε4 allele frequency intermediate between controls and Alzheimer's disease

1994 • 60 citations

Genetic anticipation in Parkinson's disease

1995 • 56 citations

Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes

1997 • 55 citations

Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan

1997 • 55 citations

Familial parkinsonism: Our experience and review

1995 • 53 citations

Apolipoprotein E4 in Parkinson Disease and Dementia

1998 • 51 citations

The dopamine transporter gene and Parkinson's disease in a Chinese population

1997 • 48 citations

Association of apolipoprotein ?4 allele and neuropathologic findings in patients with dementia

1995 • 48 citations

Monoamine oxidase, dopamine and Parkinson's disease

1991 • 45 citations

Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.

1994 • 43 citations

Frequency of the apolipoprotein E epsilon 4 allele in a case-control study of early onset Parkinson's disease.

1996 • 41 citations

CYP2D6 allelic frequencies in young-onset Parkinson's disease

1996 • 41 citations

Mutation frequencies of the cytochromeCYP2D6 gene in Parkinson disease patients and in families

1996 • 40 citations

Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons

1994 • 39 citations

“Familial Parkinson's Disease” – A Case-Control Study of Families

1997 • 39 citations

Genetic association between cytochrome P450IA1 gene and susceptibility to Parkinson's disease

1996 • 38 citations

Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease

1996 • 34 citations

No association between Parkinson's disease and monoamine oxidase A and B gene polymorphisms

1996 • 34 citations

A clinical and genetic study of familial cases of Parkinson's disease

1995 • 34 citations

The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.

1996 • 34 citations

Genetic association between susceptibility to Parkinson's disease and α1-antichymotrypsin polymorphism

1997 • 33 citations

Clinicopathological Aspects of Parkinson's Disease

1997 • 31 citations

Genetics of Parkinson's disease.

1987 • 30 citations

No evidence for association of familial Parkinson's disease with CAG repeat expansion

1995 • 27 citations

Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease

1997 • 27 citations

Familial autosomal dominant dopa responsive Parkinson's disease in three living generations showing extreme anticipation and childhood onset.

1996 • 25 citations

Anticipation of onset age in familial Parkinson's disease

1994 • 25 citations

The Familial Occurrence of Parkinson's Disease Lack of Evidence for Maternal Inheritance

1992 • 25 citations

Segregation analysis of Parkinson disease

1998 • 23 citations

Absence of the G209A mutation in the α-synuclein gene in British families with Parkinson's disease

1998 • 21 citations

A genetic study of Parkinson's disease.

1995 • 20 citations

Lack of Relation Between Genetic Polymorphism of Cytochrome P-450IID6 and Sporadic Idiopathic Parkinson's Disease

1996 • 20 citations

Frequency of a Specific Cytochrome P4502D6B (CYP2D6B) Mutant Allele in Clinically Differentiated Groups of Patients with Parkinson Disease

1995 • 19 citations

Apolipoprotein E genotype in familial Parkinson's disease

1997 • 19 citations

Anticipation in familial Parkinson's disease

1996 • 18 citations

Familial Juvenile Parkinsonism

1997 • 15 citations

Apolipoprotein E and B alleles in Parkinson's patients

1995 • 13 citations

α-Synuclein Gene and Parkinson's Disease

1998 • 13 citations

Triplet Repeat Gene Sequences in Neuropsychiatric Diseases

1997 • 10 citations

Debrisoquine hydroxylation genotype in familial forms of idiopathic Parkinson's disease.

1996 • 8 citations