Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

1992 • 9,892 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease.

1997 • 835 citations

Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

1996 • 759 citations

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Oxidative damage in neurodegenerative disease

1994 • 428 citations

Possible environmental, occupational, and other etiologic factors for Parkinson's disease

1996 • 424 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1994 • 316 citations

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

1992 • 313 citations

MPTP

1986 • 293 citations

SHORT COMMUNICATION: Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans

1993 • 293 citations

Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

1994 • 276 citations

Glutathione conjugation: Mechanisms and biological significance

1989 • 267 citations

Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer

1995 • 230 citations

Mutant debrisoquine hydroxylation genes in Parkinson's disease

1992 • 230 citations

Ethanol Increases Cytochrome P4502E1 and Induces Oxidative Stress in Astrocytes

1995 • 218 citations

Evidence for mitochondrial dysfunction in Parkinson's disease-a critical appraisal

1994 • 216 citations

Simultaneous characterization of glutathione S-transferase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks

1996 • 212 citations

Different Regulation and Expression of the Human CYP2E1 Gene Due to the Rsal Polymorphism in the 5'-Flanking Region1

1994 • 209 citations

Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology.

1993 • 209 citations

Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease.

1989 • 193 citations

A clinical and genetic study of familial Parkinson's disease

1991 • 134 citations

Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking

1995 • 130 citations

A Novel Cytochrome P-450IID6 Mutant Gene Associated with Parkinson's Disease

1993 • 68 citations

Mitochondrial DNA polymorphisms in pathologically proven Parkinson’s disease

1997 • 56 citations

Glutathione conjugation; mechanisms and biological significance

1989 • 54 citations

Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease

1996 • 34 citations

A polymorphic CfoI site in exon 6 of the human cytochrome P450 CYP2D6 gene detected by the polymerase chain reaction

1993 • 21 citations

Acetylator polymorphism in Parkinson's disease

1989 • 14 citations

Xenobiotic metabolism in idiopathic Parkinson's disease in Nigerian Africans.

1993 • 9 citations

D-Penicillamine metabolism in neurodegenerative diseases: Anin vivo/in vitrosulphydryl methylation study

1994 • 9 citations

Deleted Work

1955 • 0 citations