Association between the oxidative polymorphism and early onset of Parkinson's disease*

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

EPIDEMIOLOGY OF PARKINSON'S DISEASE

1996 • 631 citations

A routine method for the establishment of permanent growing lymphoblastoid cell lines

1986 • 628 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

A large kindred with autosomal dominant Parkinson's disease

1990 • 411 citations

Molecular genetic approach to human meningioma: loss of genes on chromosome 22.

1987 • 322 citations

Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease

1985 • 310 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Identification of ampoules.

1973 • 241 citations

Mutant debrisoquine hydroxylation genes in Parkinson's disease

1992 • 230 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

1990 • 193 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

Environmental Factors in the Etiology of Parkinson's Disease

1987 • 188 citations

PREDISPOSITION TO FAMILIAL OSTEOARTHROSIS LINKED TO TYPE II COLLAGEN GENE

1989 • 180 citations

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6

1993 • 159 citations

CONFIDENCE INTERVALS

1987 • 156 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

Fatal hypoglycaemia in a diabetic.

1948 • 136 citations

A clinical and genetic study of familial Parkinson's disease

1991 • 134 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

Twin studies and the genetics of Parkinson's disease—a reappraisal

1990 • 129 citations

New Data on the Genetics of Parkinson’s Disease

1982 • 118 citations

Epidemiology of Parkinson’s Disease

1992 • 118 citations

ANTI-VIRUS FOR LEUKAEMIA.

1964 • 117 citations

Xenobiotic metabolism in Parkinson's disease

1989 • 116 citations

Environmental and genetic factors in the etiology of Parkinson's disease.

1987 • 116 citations

β-Carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): Endogenous factors underlying idiopathic parkinsonism?

1985 • 108 citations

USE AND ABUSE OF DRUGS.

1965 • 106 citations

A Novel Cytochrome P-450IID6 Mutant Gene Associated with Parkinson's Disease

1993 • 68 citations

Debrisoquine oxidation polymorphism

1993 • 66 citations

Familial Subsets in Idiopathic Parkinson’s Disease

1984 • 63 citations

A Prospective Study of 50 Cases of Familial Parkinson’s Disease

1983 • 62 citations

The cytochrome P450 CYP2D6 allelic variant CYP 2D6J and related polymorphisms in a European population

1994 • 55 citations

Parkinson's Disease: A Genetic Study

1986 • 49 citations

Genetic basis for differences in debrisoquin polymorphism between a spanish and other white populations

1994 • 45 citations

[17] Genetic polymorphism of debrisoquine oxidation: restriction fragment analysis and allele-specific amplification of mutant alleles of CYP2D6

1991 • 43 citations

Does an endogenous methylpyridinium analogue cause Parkinson's disease?

1985 • 42 citations

Acute Effects of 1‐Methyl‐4‐Phenyl‐1, 2, 3, 6‐Tetrahydropyridine in a Model of Rat Designated a Poor Metabolizer of Debrisoquine

1991 • 37 citations

Oxidative polymorphism of debrisoquine in Parkinson's disease.

1990 • 36 citations

Endogenous analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: indoleamine derived tetrahydro-beta-carbolines as potential causative factors in Parkinson's disease.

1987 • 30 citations

Debrisoquine hydroxylation in Parkinson's disease

1992 • 26 citations

Debrisoquine hydroxylase and Parkinson's disease.

1993 • 25 citations

Debrisoquine oxidation in Parkinson's disease

1991 • 24 citations

METHYLTETRAHYDRO-β-CARBOLINES AND PARKINSON'S DISEASE

1985 • 17 citations

Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.

1993 • 7 citations

[Hydroxylation of debrisoquin in Parkinson's disease].

1990 • 5 citations

[A susceptible factor to acquire parkinsonism: sparteine oxidation polymorphism].

1989 • 2 citations