Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

1995 • 4,199 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

2000 • 1,423 citations

Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

1990 • 1,232 citations

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

1999 • 1,212 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

1994 • 1,123 citations

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

1994 • 1,068 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.

1988 • 876 citations

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats

1998 • 794 citations

Functional Recovery of Paraplegic Rats and Motor Axon Regeneration in Their Spinal Cords by Olfactory Ensheathing Glia

2000 • 786 citations

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

1990 • 775 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Robust Regeneration of Adult Sensory Axons in Degenerating White Matter of the Adult Rat Spinal Cord

1999 • 608 citations

Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

1999 • 588 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Prior Exposure to Neurotrophins Blocks Inhibition of Axonal Regeneration by MAG and Myelin via a cAMP-Dependent Mechanism

1999 • 541 citations

Neuronal Cyclic AMP Controls the Developmental Loss in Ability of Axons to Regenerate

2001 • 527 citations

Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury

2001 • 519 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function

1999 • 480 citations

BDNF and NT-4/5 Prevent Atrophy of Rat Rubrospinal Neurons after Cervical Axotomy, Stimulate GAP-43 and Tα1-Tubulin mRNA Expression, and Promote Axonal Regeneration

1997 • 477 citations

Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes

2000 • 472 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

2000 • 393 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotrophins

2001 • 378 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth

1987 • 358 citations

A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

2000 • 289 citations

A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord

1999 • 289 citations

Neuroprotection mediated by changes in the endothelial actin cytoskeleton

2000 • 283 citations

Transplantation of activated macrophages overcomes central nervous system regrowth failure

1996 • 281 citations

Activation of Locomotion in Adult Chronic Spinal Rats Is Achieved by Transplantation of Embryonic Raphe Cells Reinnervating a Precise Lumbar Level

2000 • 250 citations

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells

1996 • 206 citations

Retinal Ganglion Cells Lose Trophic Responsiveness after Axotomy

1999 • 202 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca²⁺ Signaling and Rho

1996 • 198 citations

The Neuronal Architecture ofXenopusRetinal Ganglion Cells Is Sculpted by Rho-Family GTPasesIn Vivo

1999 • 198 citations

Robust Growth of Chronically Injured Spinal Cord Axons Induced by Grafts of Genetically Modified NGF-Secreting Cells

1997 • 194 citations

Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse

1996 • 193 citations

Myelin and Collapsin-1 Induce Motor Neuron Growth Cone Collapse through Different Pathways: Inhibition of Collapse by Opposing Mutants of Rac1

1999 • 184 citations

Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: Differential regulation of GAP-43, tubulins, and neurofilament-M

1999 • 181 citations

Recovery of Locomotion After Ventral and Ventrolateral Spinal Lesions in the Cat. I. Deficits and Adaptive Mechanisms

1998 • 171 citations

p160 RhoA-binding Kinase ROKα Induces Neurite Retraction

1998 • 166 citations

Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1

1999 • 164 citations

Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat

2001 • 153 citations

Genetic Approaches to Neurotrauma Research: Opportunities and Potential Pitfalls of Murine Models

1999 • 149 citations

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

2001 • 146 citations

Transplants and Neurotrophic Factors Prevent Atrophy of Mature CNS Neurons after Spinal Cord Injury

1998 • 142 citations

Collagen implants and cortico‐spinal axonal growth after mid‐thoracic spinal cord lesion in the adult rat

1995 • 104 citations

Failure of Axon Regeneration in Postnatal Rat Entorhino‐hippocampal Slice Coculture is Due to Maturation of the Axon, not that of the Pathway or Target

1995 • 100 citations

Effects of fibrin micromorphology on neurite growth from dorsal root ganglia cultured in three-dimensional fibrin gels

1998 • 86 citations

Transplants Enhance Locomotion in Neonatal Kittens Whose Spinal Cords Are Transected: A Behavioral and Anatomical Study

1995 • 74 citations

GTPase RhoB: An Early Predictor of Neuronal Death after Transient Focal Ischemia in Mice

2001 • 66 citations

Brain-derived neurotrophic factor modulates GAP-43 but not t?1 expression in injured retinal ganglion cells of adult rats

1997 • 63 citations

Robust Regeneration of CNS Axons through a Track Depleted of CNS Glia

2000 • 63 citations

[20] Purification and assay of recombinant C3 transferase

1995 • 62 citations

Neuroprotective Effects of Gacyclidine After Experimental Photochemical Spinal Cord Lesion in Adult Rats: Dose-Window and Time-Window Effects

2000 • 49 citations

Fetal Spinal Cord Transplants and Exogenous Neurotrophic Support Enhance c-Jun Expression in Mature Axotomized Neurons after Spinal Cord Injury

1999 • 45 citations

Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats

1997 • 42 citations

The Spinal Cat

2000 • 41 citations

Thienylphencyclidine protection for the spinal cord of adult rats against extension of lesions secondary to a photochemical injury

1993 • 29 citations

Myelin‐associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse

1996 • 13 citations