Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

1981 • 1,679 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

1990 • 1,232 citations

Cell Biology: a Laboratory Handbook

1995 • 1,226 citations

Cell biology :a laboratory handbook.

1994 • 1,213 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

1994 • 1,123 citations

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

1994 • 1,068 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.

1988 • 876 citations

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats

1994 • 817 citations

Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides

1998 • 784 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Regeneration of adult axons in white matter tracts of the central nervous system

1997 • 747 citations

Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors

1995 • 723 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat

1987 • 587 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Inhibitors of Neurite Growth

1993 • 545 citations

Prior Exposure to Neurotrophins Blocks Inhibition of Axonal Regeneration by MAG and Myelin via a cAMP-Dependent Mechanism

1999 • 541 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42

1997 • 493 citations

BDNF and NT-4/5 Prevent Atrophy of Rat Rubrospinal Neurons after Cervical Axotomy, Stimulate GAP-43 and Tα1-Tubulin mRNA Expression, and Promote Axonal Regeneration

1997 • 477 citations

Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats

1993 • 458 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats

1988 • 402 citations

Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 • 384 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

Gangliosides are neuronal ligands for myelin-associated glycoprotein.

1996 • 284 citations

Role of Intracellular Calcium in NI-35-Evoked Collapse of Neuronal Growth Cones

1993 • 271 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

1996 • 263 citations

Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

1990 • 259 citations

Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS

1995 • 251 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. A quantitative in vivo study.

1996 • 244 citations

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells

1996 • 206 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca²⁺ Signaling and Rho

1996 • 198 citations

Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse

1996 • 193 citations

Disruption of the Gene for the Myelin-Associated Glycoprotein Improves Axonal Regrowth along Myelin in C57BL/Wlds Mice

1996 • 186 citations

Myelin and Collapsin-1 Induce Motor Neuron Growth Cone Collapse through Different Pathways: Inhibition of Collapse by Opposing Mutants of Rac1

1999 • 184 citations

Sialic Acid Specificity of Myelin-associated Glycoprotein Binding

1997 • 172 citations

Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.

1992 • 166 citations

p160 RhoA-binding Kinase ROKα Induces Neurite Retraction

1998 • 166 citations

Rho proteins play a critical role in cell migration during the early phase of mucosal restitution.

1997 • 163 citations

Transplants and Neurotrophic Factors Prevent Atrophy of Mature CNS Neurons after Spinal Cord Injury

1998 • 142 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

Laminin and fibronectin guideposts signal sustained but opposite effects to passing growth cones

1995 • 132 citations

The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases

1995 • 129 citations

ADP-ribosylation of the proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells

1990 • 126 citations

Different Roles for RhoA During Neurite Initiation, Elongation, and Regeneration in PC12 Cells

1999 • 126 citations

Growth Cone Form Is Behavior-Specific and, Consequently, Position-Specific along the Retinal Axon Pathway

1997 • 119 citations

Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin‐derived inhibitors of neurite growth

1995 • 114 citations

Organization of point contacts in neuronal growth cones

1999 • 100 citations

Overexpression of a Neural-specific Rho Family GTPase, cRac1B, Selectively Induces Enhanced Neuritogenesis and Neurite Branching in Primary Neurons

1998 • 92 citations

Long interfascicular axon growth from embryonic neurons transplanted into adult myelinated tracts

1994 • 91 citations

Expression of Specific Tubulin Isotypes Increases during Regeneration of Injured CNS Neurons, But Not after the Application of Brain-Derived Neurotrophic Factor (BDNF)

1997 • 80 citations

Structurally similar Drosophila alpha-tubulins are functionally distinct in vivo.

1997 • 69 citations

Functional Modification of a 21-Kilodalton G Protein when ADP-Ribosylated by Exoenzyme C3 of Clostridium botulinum

1988 • 66 citations

[20] Purification and assay of recombinant C3 transferase

1995 • 62 citations

Tenascin in the injured rat optic nerve and in non‐neuronal cells in vitro: Potential role in neural repair

1994 • 61 citations

[22] Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation

1995 • 57 citations

Ethylene-Vinyl Acetate Copolymer Microspheres for Controlled Release of Macromolecules

1984 • 47 citations

Neurite Outgrowth on Non‐permissive Substrates In Vitro is Enhanced by Ectopic Expression of the Neural Adhesion Molecule L1 by Mouse Astrocytes

1996 • 44 citations

Selective Inhibition of Early Axonal Regeneration by Myelin-Associated Glycoprotein

1998 • 37 citations

ADP-ribosylation of the G Protein Rho Inhibits Integrin Regulation of Tumor Cell Growth

1996 • 36 citations

Unique Responses of Differentiating Neuronal Growth Cones to Inhibitory Cues Presented by Oligodendrocytes

1998 • 28 citations

Inhibition of PC12 Cell Attachment and Neurite Outgrowth by Detergent Solubilized CNS Myelin Proteins

1995 • 26 citations

Myelin‐associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse

1996 • 13 citations

ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth

1996 • 5 citations

How the camel got his hump

1996 • 1 citations