Ethanol Metabolism in Perfused Liver and Isolated Hepatocytes with Associated Methodologies

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Untersuchungen uber die Harnstoffbildung im Tierkörper

1932 • 3,104 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS

1951 • 806 citations

Enzymac characterization and lipid composition of rat liver subcellular membranes

1971 • 643 citations

Wege des Wasserstoffs in der lebendigen Organisation

1958 • 635 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Properties of catalase. Catalysis of coupled oxidation of alcohols

1945 • 441 citations

PHOSPHORYLATION COUPLED TO OXIDATION OF DIHYDRODIPHOSPHOPYRIDINE NUCLEOTIDE

1951 • 423 citations

The cause of hepatic accumulation of fructose 1-phosphate on fructose loading

1970 • 404 citations

Regulation of Hepatic Metabolism

1986 • 394 citations

Liver Adenine Nucleotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis

1968 • 333 citations

Metabolic Effects of Ethanol in Perfused Rat Liver

1969 • 327 citations

Rapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells

1974 • 324 citations

Organ perfusion and preservation

1968 • 312 citations

The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.

1972 • 290 citations

Funktionelle und Morphologische Organisation der Zelle

1963 • 259 citations

Flavin and Pyridine Nucleotide Oxidation-Reduction Changes in Perfused Rat Liver

1969 • 255 citations

Use of Isolated Liver Cells and Kidney Tubules in Metabolic Studies

1976 • 252 citations

The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver

1972 • 250 citations

A simple and inexpensive membrane “lung” for small organ perfusion

1974 • 236 citations

Effects of chronic ethanol treatment on mitochondrial functions damage to coupling site I

1974 • 215 citations

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

1977 • 208 citations

The characteristics of the ‘peroxidatic’ reaction of catalase in ethanol oxidation

1973 • 195 citations

Functional Compartmentation of Acetaldehyde Oxidation in Rat Liver

1974 • 193 citations

Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes.

1975 • 189 citations

Metabolic alterations produced in the liver by chronic ethanol administration. Increased oxidative capacity

1973 • 187 citations

The Regulation of Gluconeogenesis in Isolated Rat Liver Cells by Glucagon, Insulin, Dibutyryl Cyclic Adenosine Monophosphate, and Fatty Acids

1972 • 180 citations

Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration

1970 • 178 citations

Effect of insulin on potassium transfer in isolated rat liver

1961 • 177 citations

HEMOGLOBIN-FREE PERFUSION OF RAT LIVER**Supported by grants of the Squibb Institute for Medical Research, New Brunswick, New Jersey.

1965 • 167 citations

Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption

1977 • 164 citations

Control of Energy Metabolism

1976 • 160 citations

Acceleration of gluconeogenesis from lactate by lysine (Short Communication)

1973 • 155 citations

Perfusion techniques in biochemistry

1973 • 145 citations

Pyrazole Inhibition and Kinetic Studies of Ethanol and Retinol Oxidation Catalyzed by Rat Liver Alcohol Dehydrogenase.

1969 • 140 citations

Acetaldehyde Oxidation by Hepatic Mitochondria: Decrease After Chronic Ethanol Consumption

1975 • 139 citations

Characterization of carnitine acylcarnitine translocase system of heart mitochondria.

1976 • 138 citations

Alcohol and Aldehyde Metabolizing Systems

1977 • 138 citations

The Location of Different Synthetic Systems for Fatty Acids in Inner and Outer Mitochondrial Membranes from Rabbit Heart

1969 • 136 citations

Rate‐Limiting Factors in Ethanol Oxidation by Isolated Rat‐Liver Parenchymal Cells

1973 • 130 citations

Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver

1972 • 122 citations

Lipid Peroxidation in Isolated Hepatocytes

1975 • 118 citations

Measurement of the ATP/ADP Ratio in Mitochondria and in the Extramitochondrial Compartment by Fractionation of Freeze-Stopped Liver Tissue in Non-aqueous Media

1974 • 117 citations

Control of the Removal of Reducing Equivalents from the Cytosol in Perfused Rat Liver

1971 • 115 citations

Recycling of Glucose by Rat Hepatocytes

1975 • 109 citations

Hydrogen transport and transport metabolites

1963 • 107 citations

Rate-limiting factors in the oxidation of ethanol by isolated rat liver cells

1975 • 107 citations

Oxidation of Acetaldehyde by Rat‐Liver Mitochondria in Relation to Ethanol Oxidation and the Transport of Reducing Equivalents across the Mitochondrial Membrane

1973 • 101 citations

Regulation of Glucose Synthesis in Hormone-Sensitive Isolated Rat Hepatocytes

1973 • 100 citations

Ethanol oxidation by liver microsomes: Evidence against a separate and distinct enzyme system

1970 • 98 citations

Effects of aminooxyacetate on the metabolism of isolated liver cells

1974 • 98 citations

Regulatory Role of Reducing‐Equivalent Transfer from Substrate to Oxygen in the Hepatic Metabolism of Glycerol and Sorbitol

1973 • 97 citations

Effects of Ethanol and Fat on the Transport of Reducing Equivalents into Rat Liver Mitochondria

1973 • 82 citations

Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo

1975 • 79 citations

Alcohol Oxidation in Rats Inhibited by Pyrazole, Oximes, and Amides

1970 • 78 citations

The Equilibrium Constant of the System Ethanol, Aldehyde, DPN+, DPNH and H+.

1958 • 71 citations

Mechanism of glutamate-aspartate translocation across the mitochondrial inner membrane

1976 • 66 citations

Mechanism of the Stimulatory Effect of Fructose on Ethanol Oxidation in Perfused Rat Liver

1976 • 65 citations

Influence of Ethanol on the Redox State of the Liver

1970 • 63 citations

Metabolism of Ethanol and Fructose in the Perfused Rat Liver

1970 • 57 citations

Effects of pyrazole and 3-amino-1,2,4-triazole on methanol and ethanol metabolism by the rat

1973 • 55 citations

Rate-Limiting Steps in Ethanol Metabolism and Approaches to Changing These Rates Biochemically

1975 • 54 citations

Effect of 2,4-dinitrophenol on the rate of ethanol elimination in the rat in vivo

1970 • 53 citations

The Effect of Ethanol Concentration on Ethanol Oxidation Rate in Rat Liver Slices.

1971 • 49 citations

A New Membrane Oxygenator-Dialyzer

1967 • 46 citations

Characteristics of Ethanol and Acetaldehyde Oxidation on Flavin and Pyridine Nucleotide Fluorescence Changes in Perfused Rat Liver

1974 • 46 citations

Glucagon control of cyclic AMP accumulation in isolated intact rat liver parenchymal cells in vitro

1974 • 44 citations

Oxidation of extramitochondrial NADH by rat liver mitochondria. Possible role of acyl-SCoA elongation enzymes

1970 • 37 citations

2,4-dinitrophenol-induced increase in ethanol and acetaldehyde oxidation in the perfused rat liver

1974 • 37 citations

THE EFFECT OF ACETATE, PYRUVATE, AND GLUCOSE ON ALCOHOL METABOLISM

1954 • 36 citations

Does Catalase Participate in the Physiological Oxidation of Alcohols?

1952 • 36 citations

Metabolism of Ethanol

1977 • 35 citations

The increased rate of ethanol removal from blood of clofibrate-treated rats (Short Communication)

1974 • 35 citations

Effect of chronic ethanol consumption and acetaldehyde on partial reactions of oxidative phosphorylation and CO2 production from citric acid cycle intermediates

1976 • 34 citations

Absence of ethanol metabolism in ‘acatalatic’ hepatic microsomes that oxidize drugs

1973 • 32 citations

Effect of ammonia on mitochondrial and cytosolic NADH and NADPH systems in isolated rat liver cells

1977 • 32 citations

Oxidation of Glycerol 3-Phosphate by the Perfused Rat Liver

1972 • 31 citations

Factors Controlling the Rate of Alcohol Disposal by the Liver

1975 • 30 citations

The oxidation of acetaldehyde by isolated mitochondria from various organs of the rat and hepatocellular carcinoma

1977 • 30 citations

Activation of Ethanol Utilization in Perfused Liver from Normal and Ethanol-Pretreated Rats. The Effect of Hydrogen Peroxide Generating Substrates

1974 • 29 citations

Minimal apparent blood damage in Landé-Edwards membrane oxygenator at physiologic gas tensions

1970 • 25 citations

Catalase involvement in microsomal ethanol-oxidizing system

1972 • 25 citations

Fibrinolysis during Extracorporeal Circulation

1971 • 23 citations

Role of the malate—aspartate shuttle in the metabolism of ethanol in vivo

1975 • 22 citations

Activation of ethanol metabolism by 2,4-dinitrophenol in the isolated perfused rat liver

1974 • 21 citations

THE INTERRELATIONSHIP BETWEEN FRUCTOSE AND ETHANOL METABOLISM IN THE ISOLATED PERFUSED PIG LIVER

1972 • 19 citations

IN VIVO METABOLISM OF ETHANOL AT HIGH AND LOW CONCENTRATIONS

1977 • 17 citations

THE ROLE OF ALCOHOL DEHYDROGENASE IN GOVERNING RATES OF ETHANOL METABOLISM IN RATS

1977 • 16 citations

The Energy-linked Incorporation of Diphosphopyridine Nucleotide into Rat Liver Mitochondria

1968 • 15 citations

Microsomal Ethanol Oxidation: Activity in Vitro and in Vivo

1975 • 15 citations

Untersuchungen zur Redoxkompartmentierung bei der hämoglobinfrei perfundierten Rattenleber

1968 • 13 citations

The Stimulatory Effect of Fructose on Ethanol Metabolism

1975 • 12 citations

OXIDATION OF REDUCING EQUIVALENTS DURING ETHANOL METABOLISM. STUDIES WITH 1−3H-ETHANOL

1977 • 5 citations

FACTORS ALTERING THE RATE OF ALCOHOL METABOLISM IN HEPATOCYTES

1977 • 4 citations

Improved isolated liver cell preparation: Monitoring hydrostatic pressure and return flow during liver perfusion

1977 • 3 citations