Early intervention in bipolar disorders: Clinical, biochemical and neuroimaging imperatives

Free radicals in biology and medicine

1991 • 17,840 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Free radicals in biology and medicine

1985 • 2,999 citations

The Long-term Natural History of the Weekly Symptomatic Status of Bipolar I Disorder

2002 • 2,037 citations

Transduction of psychosocial stress into the neurobiology of recurrent affective disorder

1992 • 1,822 citations

Manic-depressive illness

1991 • 1,538 citations

Role of Free Radicals in the Neurodegenerative Diseases

2001 • 1,490 citations

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

2003 • 1,188 citations

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

2008 • 1,002 citations

Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression

2007 • 917 citations

Screening for Bipolar Disorder in the Community

2003 • 678 citations

Family, twin, and adoption studies of bipolar disorder

2003 • 677 citations

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 • 604 citations

Hippocampal and Amygdala Volumes According to Psychosis Stage and Diagnosis

2006 • 593 citations

The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review

2001 • 574 citations

Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder

2001 • 568 citations

Cognitive–behavioural therapy for severe and recurrent bipolar disorders

2006 • 562 citations

Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials

2004 • 553 citations

Oxidative stress markers in bipolar disorder: A meta-analysis

2008 • 500 citations

Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder

2000 • 496 citations

Electron microscopy of oligodendroglia in severe mental illness

2001 • 482 citations

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

2008 • 479 citations

A Functional Magnetic Resonance Imaging Study of Bipolar Disorder

2003 • 472 citations

Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

2007 • 470 citations

Suicide and Attempted Suicide in Bipolar Disorder

2005 • 437 citations

Astrocyte apoptosis: implications for neuroprotection

2004 • 431 citations

Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

2008 • 416 citations

Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes

2006 • 394 citations

Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients

2003 • 392 citations

The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH

1985 • 392 citations

Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain

2001 • 368 citations

Course and outcome in bipolar affective disorder: a longitudinal follow- up study

1995 • 366 citations

Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

2003 • 362 citations

Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder

1997 • 358 citations

Ventricular and Periventricular Structural Volumes in First- Versus Multiple-Episode Bipolar Disorder

2002 • 354 citations

Antidepressants in bipolar disorder: the case for caution

2003 • 351 citations

Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders

1998 • 341 citations

Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder

2002 • 330 citations

Serum S100B and antioxidant enzymes in bipolar patients

2006 • 311 citations

Subgenual Cingulate Cortex Volume in First-Episode Psychosis

1999 • 304 citations

Antidepressant‐induced mania: an overview of current controversies

2003 • 301 citations

Role of BDNF in bipolar and unipolar disorder: Clinical and theoretical implications

2007 • 283 citations

Therapeutic aspects of cannabis and cannabinoids

2001 • 269 citations

BDNF gene is a risk factor for schizophrenia in a Scottish population

2005 • 265 citations

The clinical features of bipolar depression: a comparison with matched major depressive disorder patients.

2001 • 258 citations

Expression of brain‐derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs

2002 • 239 citations

Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

2001 • 232 citations

The bipolar spectrum: a clinical reality in search of diagnostic criteria and an assessment methodology

1999 • 230 citations

Setting the stage: from prodrome to treatment resistance in bipolar disorder

2007 • 227 citations

Differential Effect of Number of Previous Episodes of Affective Disorder on Response to Lithium or Divalproex in Acute Mania

1999 • 226 citations

Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders

2007 • 226 citations

Diagnosis-Related Regional Gray Matter Loss Over Two Years in First Episode Schizophrenia and Bipolar Disorder

2005 • 225 citations

Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode

2006 • 223 citations

Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical Cells

2005 • 215 citations

History of illness prior to a diagnosis of bipolar disorder or schizoaffective disorder

2007 • 215 citations

The Clinical Features of Bipolar Depression

2001 • 213 citations

Course of a clinical cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985.

1995 • 212 citations

Structural Brain Abnormalities in Bipolar Affective Disorder

1990 • 208 citations

Structural brain abnormalities in first-episode mania

1993 • 206 citations

Polarity of the first episode, clinical characteristics, and course of manic depressive illness: A systematic retrospective investigation of 320 bipolar I patients

2000 • 204 citations

Identifying Functional Neuroimaging Biomarkers of Bipolar Disorder: Toward DSM-V

2007 • 198 citations

Voxel-Based Study of Structural Changes in First-Episode Patients with Bipolar Disorder

2006 • 193 citations

Inducing lifestyle regularity in recovering bipolar disorder patients: Results from the maintenance therapies in bipolar disorder protocol

1997 • 190 citations

Course of illness in depressive and bipolar disorders

2004 • 182 citations

Polymorphism of the brain‐derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients

2003 • 181 citations

Glutathione: a novel treatment target in psychiatry

2008 • 179 citations

Changes in Gray Matter Volume in Patients with Bipolar Disorder

2005 • 171 citations

Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients.

1986 • 169 citations

Cognitive generation of affect in bipolar depression: an fMRI study

2004 • 167 citations

Course and outcome of bipolar spectrum disorder in children and adolescents: A review of the existing literature

2006 • 165 citations

White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders

2002 • 158 citations

The potential utility of a staging model as a course specifier: A bipolar disorder perspective

2007 • 149 citations

Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder

2000 • 148 citations

Bipolar Disorder in Children Misdiagnosis, Underdiagnosis, and Future Directions

1995 • 148 citations

Lower Switch Rate in Depressed Patients With Bipolar II Than Bipolar I Disorder Treated Adjunctively With Second-Generation Antidepressants

2006 • 147 citations

An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)

2003 • 143 citations

The Bipolar Depression Rating Scale (BDRS): its development, validation and utility

2007 • 141 citations

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers

2001 • 141 citations

Confirmation of association between the Val66Met polymorphism in the brain‐derived neurotrophic factor (BDNF) gene and bipolar I disorder

2005 • 140 citations

Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: Impact of past episodes

2006 • 139 citations

Stress reactivity in bipolar patients and its relation to prior history of disorder

1997 • 138 citations

Misdiagnosed Patients With Bipolar Disorder

2005 • 134 citations

Toward a validation of a new definition of agitated depression as a bipolar mixed state (mixed depression)

2004 • 130 citations

Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report

2006 • 120 citations

Temporal lobe measurement in primary affective disorder by magnetic resonance imaging

1989 • 118 citations

Relationship between craving and personality in treatment-seeking women with substance-related disorders

2003 • 118 citations

Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder

2003 • 114 citations

Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers

2001 • 113 citations

Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania

2006 • 110 citations

Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

2007 • 109 citations

Psychopathology in children of bipolar parents

2007 • 108 citations

Treatment‐latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disorders

2003 • 104 citations

PACE: a specialised service for young people at risk of psychotic disorders

2007 • 103 citations

Rate of switch in bipolar patients prospectively treated with second‐generation antidepressants as augmentation to mood stabilizers

2001 • 102 citations

Magnetic Resonance Spectroscopy and its Applications in Psychiatry

2002 • 95 citations

The proximal prodrome to first episode mania – a new target for early intervention

2008 • 94 citations

First-Episode Mania: A Neglected Priority for Early Intervention

2002 • 88 citations

A review of antidepressant‐induced hypomania in major depression: suggestions for DSM‐V

2004 • 85 citations

Bipolar disorder: diagnostic challenges and treatment considerations.

2000 • 83 citations

Seasonal changes, sleep length and circadian preference among twins with bipolar disorder

2003 • 83 citations

Making sense of neuroimaging in psychiatry

2007 • 82 citations

Differential Efficacy of Olanzapine and Lithium in Preventing Manic or Mixed Recurrence in Patients With Bipolar I Disorder Based on Number of Previous Manic or Mixed Episodes

2006 • 81 citations

Bipolar disorder in adolescence and young adulthood

2002 • 79 citations

DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia

2007 • 74 citations

Bipolar offspring

2003 • 73 citations

Seasonal variation of mixed and pure episodes of bipolar disorder

2002 • 71 citations

Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats

2006 • 70 citations

Are treatment emergent suicidality and decreased response to antidepressants in younger patients due to bipolar disorder being misdiagnosed as unipolar depression?

2005 • 69 citations

Meta-analysis of brain size in bipolar disorder

1999 • 68 citations

Emotion and its disorders

2003 • 64 citations

N‐acetylaspartate levels in bipolar offspring with and at high‐risk for bipolar disorder

2005 • 64 citations

Scale matters: the need for a Bipolar Depression Rating Scale (BDRS)

2004 • 61 citations

Are antidepressants less effective in the acute treatment of bipolar I compared to unipolar depression?

2001 • 60 citations

Anatomical MRI Abnormalities in Bipolar Disorder: Do They Exist and Do They Progress?

2005 • 59 citations

Corpus callosum areas in first-episode patients with bipolar disorder

2007 • 59 citations

Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study

2004 • 59 citations

‘Bipolar Missed States’: The Diagnosis and Clinical Salience of Bipolar Mixed States

2005 • 59 citations

The recognition and optimal management of early psychosis: an evidence-based reform.

2002 • 58 citations

Does prophylaxis‐delay in bipolar disorder influence outcome? Results from a long‐term study of 147 patients

2003 • 56 citations

Anatomical MRI abnormalities in bipolar disorder: do they exist and do they progress?

2005 • 55 citations

Hippocampal ¹H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine

2006 • 51 citations

One‐year outcome with antidepressant – treatment of bipolar depression

2005 • 46 citations

Predictors of bipolar disorder risk among patients currently treated for major depression.

2006 • 45 citations

Pharmacological Treatment in the Early Phase of Bipolar Disorders: What Stage are we at?

2006 • 42 citations

Seasonal variation in hospital admission for bipolar disorder, depression and schizophrenia in Tasmania

2000 • 39 citations

Seasons and Bipolar Disorder

1995 • 37 citations

What is to be done? Controversies in the Diagnosis and Treatment of Manic-Depressive Illness

2000 • 37 citations

'Bipolar missed states': the diagnosis and clinical salience of bipolar mixed states

2005 • 29 citations

Rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder

2007 • 28 citations

Recovery from episodes during the course of affective disorder: a case‐register study

1999 • 24 citations

Seasonal influences on first-episode admission in affective and non-affective psychosis

2006 • 16 citations

Affective disorder subtyped by psychomotor symptoms, monoamine oxidase, melatonin and cortisol: identification of patients with latent bipolar disorder

1998 • 15 citations

Demographical profile and clinical features of patients with bipolar disorder in an outpatient setting in Singapore.

2008 • 15 citations

Aspects médico-légaux des troubles bipolaires

2006 • 4 citations