Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Estimation of metabolite concentrations from localized in vivo proton NMR spectra

1993 • 3,535 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

2007 • 1,742 citations

Spatial Localization in NMR Spectroscopy in Vivo

1987 • 1,342 citations

Angiogenesis in brain tumours

2007 • 1,314 citations

Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor

2006 • 1,305 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

2004 • 1,176 citations

NMR chemical shift imaging in three dimensions.

1982 • 1,033 citations

¹H NMR chemical shift selective (CHESS) imaging

1985 • 1,016 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

WET, a T1- and B1-Insensitive Water-Suppression Method for in Vivo Localized 1H NMR Spectroscopy

1994 • 682 citations

Diffusion Magnetic Resonance Imaging: an Early Surrogate Marker of Therapeutic Efficacy in Brain Tumors

2000 • 677 citations

FDA Drug Approval Summary: Bevacizumab (Avastin®) as Treatment of Recurrent Glioblastoma Multiforme

2009 • 580 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiationRole of oxygenation, angiopoietin-1, and matrix metalloproteinases

2004 • 549 citations

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

2010 • 502 citations

Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

2009 • 494 citations

Role of Vascular Endothelial Growth Factor in Ovarian Cancer

1998 • 396 citations

Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study

1996 • 363 citations

Multisection proton MR spectroscopic imaging of the brain.

1993 • 355 citations

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

1994 • 301 citations

Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice

2009 • 299 citations

Human brain tumors: assessment with in vivo proton MR spectroscopy.

1993 • 287 citations

Human brain tumors: spectral patterns detected with localized H-1 MR spectroscopy.

1992 • 265 citations

Antiangiogenic Therapy of a Recurrent Giant Cell Tumor of the Mandible With Interferon Alfa-2a

1999 • 245 citations

Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra

2006 • 228 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

1999 • 222 citations

Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole.

1992 • 218 citations

¹H MR spectroscopy of brain tumours and masses

2003 • 211 citations

Multivoxel magnetic resonance spectroscopy of brain tumors.

2003 • 201 citations

Survival analysis in patients with glioblastoma multiforme: Predictive value of choline‐to‐n‐acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume

2004 • 193 citations

VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer

2009 • 187 citations

In Vivo 3-T MR Spectroscopy in the Distinction of Recurrent Glioma versus Radiation Effects: Initial Experience

2002 • 149 citations

What brings pericytes to tumor vessels?

2003 • 143 citations

Choline Phospholipid Metabolism in Cancer: Consequences for Molecular Pharmaceutical Interventions

2006 • 142 citations

Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.

1999 • 129 citations

Vascular morphology and angiogenesis in glial tumors

1995 • 126 citations

Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor

2000 • 106 citations

Proton Magnetic Resonance Spectroscopy of Pediatric Brain Tumors

1992 • 101 citations

Proton MR spectroscopy of common brain tumors.

1998 • 90 citations

Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain

1999 • 90 citations

Radiation-induced changes in human brain metabolites as studied by 1H nuclear magnetic resonance spectroscopy in vivo

1995 • 87 citations

Successful Antiangiogenic Therapy of Giant Cell Angioblastoma With Interferon Alfa 2b: Report of 2 Cases

2002 • 78 citations

High-resolution 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro

1994 • 62 citations

Role of short TE 1H-MR spectroscopy in monitoring of post-operation irradiated patients

1999 • 41 citations

Hydrogen Magnetic Resonance Spectroscopy Follow-up After Radiation Therapy of Human Brain Cancer Unexpected Inverse Correlation Between the Changes in Tumor Choline Level and Post-Gadolinium Magnetic Resonance Imaging Contrast

1995 • 34 citations

Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours

1995 • 24 citations