Disruption in the leptin–NPY link underlies the pandemic of diabetes and metabolic syndrome: New therapeutic approaches

Markers of Inflammation and Cardiovascular Disease

2003 • 6,067 citations

The Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged Men

2002 • 5,087 citations

Mechanisms linking obesity to insulin resistance and type 2 diabetes

2006 • 4,896 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

Obesity, Metabolic Syndrome, and Cardiovascular Disease

2004 • 1,318 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

MARKERS OF INFLAMMATION AND CARDIOVASCULAR DISEASE

2003 • 1,029 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Abdominal Obesity and Dyslipidemia in the Metabolic Syndrome: Importance of Type 2 Diabetes and Familial Combined Hyperlipidemia in Coronary Artery Disease Risk

2004 • 492 citations

Appetite control

2005 • 414 citations

Metabolic syndrome and cardiovascular disease

2007 • 382 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

1999 • 200 citations

Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆

1999 • 191 citations

Tracing from Fat Tissue, Liver, and Pancreas: A Neuroanatomical Framework for the Role of the Brain in Type 2 Diabetes

2005 • 181 citations

NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy

2004 • 181 citations

Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity

2003 • 178 citations

Evidence for the Existence of Distinct Central Appetite, Energy Expenditure, and Ghrelin Stimulation Pathways as Revealed by Hypothalamic Site-Specific Leptin Gene Therapy

2002 • 104 citations

Stimulation of Appetite by Ghrelin Is Regulated by Leptin Restraint: Peripheral and Central Sites of Action

2005 • 103 citations

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

2001 • 100 citations

Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia

2002 • 96 citations

Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions

2007 • 94 citations

The effects of high fat diets on the blood–brain barrier transport of leptin: Failure or adaptation?

2006 • 79 citations

Leptin Expression in Hypothalamic PVN Reverses Dietary Obesity and Hyperinsulinemia but Stimulates Ghrelin*

2003 • 64 citations

Long-Term Suppression of Weight Gain, Adiposity, and Serum Insulin by Central Leptin Gene Therapy in Prepubertal Rats: Effects on Serum Ghrelin and Appetite-Regulating Genes

2002 • 64 citations

Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic sites associated with inhibition of NPY-induced food intake

1998 • 58 citations

Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice

2006 • 54 citations

Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice

2000 • 53 citations

Leptin as an adjunct of insulin therapy in insulin-deficient diabetes

2003 • 52 citations

Combined Deletion of Y1, Y2, and Y4 Receptors Prevents Hypothalamic Neuropeptide Y Overexpression-Induced Hyperinsulinemia despite Persistence of Hyperphagia and Obesity

2006 • 51 citations

High‐fat Diet‐induced Ultradian Leptin and Insulin Hypersecretion are Absent in Obesity‐resistant Rats*

2005 • 47 citations

Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight

2005 • 46 citations

Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin

2006 • 37 citations

Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy

2005 • 37 citations

Hypothalamic clamp on insulin release by leptin-transgene expression

2006 • 35 citations

Suppression of fat deposition for the life time with gene therapy

2005 • 34 citations

Obesity and metabolic syndrome: Long-term benefits of central leptin gene therapy

2002 • 32 citations

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

2008 • 30 citations

Low abundance of NPY in the hypothalamus can produce hyperphagia and obesity

2007 • 14 citations

To subjugate NPY is to improve the quality of life and live longer

2007 • 13 citations