Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

1999 • 862 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

1998 • 691 citations

A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells

1996 • 624 citations

Gene Therapy Vectors Based on Adeno-Associated Virus Type 1

1999 • 529 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

1991 • 414 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia¹

1999 • 250 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

1997 • 212 citations

Nutritional Infertility: The Role of the Interconnected Hypothalamic Neuropeptide Y–Galanin–Opioid Network

1996 • 207 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

The Development of Human Gene Therapy

1999 • 164 citations

Adeno-associated virus vectors

1992 • 161 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis.

1992 • 159 citations

Daily Changes in Hypothalamic Gene Expression of Neuropeptide Y, Galanin, Proopiomelanocortin, and Adipocyte Leptin Gene Expression and Secretion: Effects of Food Restriction¹

1999 • 147 citations

THE DEVELOPMENT OF HUMAN GENE THERAPY

1999 • 139 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Anorectic Effects of the Cytokine, Ciliary Neurotropic Factor, Are Mediated by Hypothalamic Neuropeptide Y: Comparison with Leptin*

1998 • 132 citations

Neonatal Intramuscular Injection with Recombinant Adeno-Associated Virus Results in Prolonged beta-Glucuronidase Expression in Situ and Correction of Liver Pathology in Mucopolysaccharidosis Type VII Mice

1999 • 129 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting

1999 • 128 citations

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

1997 • 124 citations

Abnormal regulation of the leptin gene in the pathogenesis of obesity

1998 • 119 citations

Effect of leptin deficiency on metabolic rate inob/obmice

1999 • 113 citations

Leptin: A Molecule Integrating Somatic Energy Stores, Energy Expenditure and Fertility

1998 • 111 citations

In VivoEffects of Leptin-Related Synthetic Peptides on Body Weight and Food Intake in Female ob/obMice: Localization of Leptin Activity to Domains Between Amino Acid Residues 106–140*

1997 • 104 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis [published erratum appears in Endocrinology 1996 Feb;137(2):532]

1992 • 91 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia

1999 • 73 citations

Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat

1998 • 64 citations

The anti-gonadotropic effects of cytokines: the role of neuropeptides

1998 • 64 citations

Regulation of proopiomelanocortin gene expression by neuropeptide Y in the rat arcuate nucleus

1995 • 62 citations

Brain mechanisms in cytokine-induced anorexia

1999 • 60 citations

Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor

1998 • 59 citations

Anorectic Effects of the Cytokine, Ciliary Neurotropic Factor, Are Mediated by Hypothalamic Neuropeptide Y: Comparison with Leptin

1998 • 56 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 53 citations

Neuropeptide Y Counteracts the Anorectic and Weight Reducing Effects of Ciliary Neurotropic Factor

2000 • 53 citations

In Vivo Effects of Leptin-Related Synthetic Peptides on Body Weight and Food Intake in Female ob/ob Mice: Localization of Leptin Activity to Domains Between Amino Acid Residues 106-140

1997 • 46 citations

Regulation of α‐Melanocyte‐Stimulating Hormone Release from Hypothalamic Neurons^a

1993 • 40 citations

Daily Changes in Hypothalamic Gene Expression of Neuropeptide Y, Galanin, Proopiomelanocortin, and Adipocyte Leptin Gene Expression and Secretion: Effects of Food Restriction

1999 • 38 citations

Neuropeptide Y stimulates β-endorphin release in the basal hypothalamus: role of gonadal steroids

1995 • 30 citations

Deleted Work

1955 • 0 citations