Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system

1988 • 1,947 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

The Protein Data Bank

1977 • 716 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

1983 • 540 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

On the calculation of electrostatic interactions in proteins

1985 • 331 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

The Chemistry and Mechanism of Antibody Binding to Protein Antigens

1988 • 212 citations

Evolution of Antibody Variable Region Structure during the Immune Response

1987 • 149 citations

Two kappa immunoglobulin genes are expressed in the myeloma S107

1981 • 117 citations

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.

1981 • 109 citations

Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons.

1981 • 99 citations

Hybridoma technology in the biosciences and medicine

1987 • 90 citations

Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii.

1987 • 87 citations

Antigen-binding mutants of mouse myeloma cells.

1977 • 82 citations

Somatic Mutation in Anti‐Phosphorylcholine Antibodies

1987 • 82 citations

The determination of binding constants for binding between carbohydrate ligands and certain proteins

1974 • 68 citations

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.

1988 • 66 citations

Rat anti-T15 monoclonal antibodies with specificity for VH and VH-VL epitopes

1984 • 57 citations

Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

1986 • 56 citations

Hybridoma technology in the biosciences and medicine

1986 • 55 citations

Mouse Immunoglobulin Heavy Chains Are Coded by Multiple Germ Line Variable Region Genes

1974 • 53 citations

Molecular Dynamics and Minimum Energy Conformations of GnRH and Analogs: A Methodology for Computer‐aided Drug Design^a

1985 • 51 citations

Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.

1987 • 48 citations

Recognition and interactions controlling the assemblies of beta barrel domains

1986 • 46 citations

Interaction Between K^b and Q4 Gene Sequences Generates the K^bm6 Mutation

1986 • 25 citations