Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Absolute Macrophage Dependency of T Lymphocyte Activation by Mitogens

1976 • 425 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

Two genes in the major histocompatibility complex control immune response

1975 • 291 citations

The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes.

1979 • 268 citations

ACTIVATION OF T AND B LYMPHOCYTES IN VITRO

1974 • 231 citations

Long-term culture of human antigen-specific cytotoxic T-cell lines.

1978 • 220 citations

Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS.

1978 • 172 citations

T‐CELL GROWTH FACTOR‐MEDIATED T‐CELL PROLIFERATION*

1979 • 168 citations

Induction of antibody‐forming cell clones in microcultures

1972 • 155 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

Biochemical Relationship of Thymocyte Mitogenic Factor and Factors Enhancing Humoral and Cell-Mediated Immune Responses

1978 • 125 citations

A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.

1977 • 122 citations

The Effect of T Cell Growth Factor on the Generation of Cytolytic T Cells

1978 • 113 citations

In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells

1977 • 87 citations

Molecular and Quantitative Analysis of Helper T Cell-Replacing Factors on the Induction of Antigen-Sensitive B and T Lymphocytes

1979 • 86 citations

Partial Purification and Molecular Characterization of a Lymphokine (Costimulator) Required for the Mitogenic Response of Mouse Thymocytes in Vitro

1978 • 86 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.

1976 • 85 citations

The Purification and Quantitation of Helper T Cell-Replacing Factors Secreted by Murine Spleen Cells Activated by Concanavalin A

1979 • 82 citations

Evidence for the identification of lymphocyte activating factor as the adherent cell-derived mediator responsible for enhanced antibody synthesis by nude mouse spleen cells

1978 • 80 citations

Effects of Costimulator on Immune Responses in Vitro

1978 • 75 citations

In vitro studies on H‐2‐linked unresponsiveness to synthetic polypeptides

1977 • 72 citations

T Cell-dependent Mediator in the Immune Response

1973 • 70 citations

Helper T Cell-Replacing Factors Secreted by Thymus-Derived Cells and Macrophages: Cellular Requirements for B Cell Activation and Synergistic Properties

1979 • 70 citations

Further studies on the thymocyte stimulating factor

1976 • 67 citations

Association of a Low Molecular Weight Helper Factor(s) with Thymocyte Proliferative Activity

1977 • 65 citations

Biochemical Relationship between Murine Immune Interferon and a Killer Cell Helper Factor

1979 • 64 citations

Reconstitution of the Antibody Response in Vitro of T Cell-Deprived Spleen Cells by Supernatants from Spleen Cell Cultures

1972 • 64 citations

In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor- allogeneic effect factor

1977 • 45 citations

Basis for the Probit Analysis of an Interferon Plaque Reduction Assay

1972 • 40 citations

Partial characterization and purification of murine T cell-replacing factor, TRF—II

1978 • 40 citations

A replicator for handling and sampling microcultures in tissue culture trays

1972 • 34 citations

T cell-dependent mediator in the immune response. II. Physical and biological properties.

1974 • 33 citations

Identification and Partial Purification of Two Synergistically Acting Helper Mediators in Human Mixed Leukocyte Culture Supernatants

1977 • 32 citations

Characterization of Mitogenic Factors and Their Effect on the Antibody Response in Vitro

1979 • 24 citations

Activation of T and B lymphocytes in vitro. VI. Biochemical and physicochemical characterization of the allogeneic effect factor.

1977 • 23 citations

Helper T cells are required for the polyclonal stimulation of cytotoxic T cells by concanavalin A.

1977 • 16 citations

Isolation of Monoclonal Antibody by Preparative Isoelectric Focusing in Horizontal Layers of Sephadex G-75

1979 • 10 citations

Generation of T helper cells in vitro. III. Helper cell culture-derived factors are related to alloantigens coded for the I region of the H-2 major histocompatibility complex.

1977 • 10 citations

Humoral factors involved in lymphocte communication and the induction of antibody synthesis

1979 • 5 citations