Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

1957 • 1,528 citations

Prolongation of the Disease-Free Interval in Surgically Treated Rectal Carcinoma

1985 • 1,097 citations

Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil. The gastrointestinal tumor study group

1981 • 1,038 citations

Studies on fluorinated pyrimidines. II. Effects on transplanted tumors.

1958 • 436 citations

Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays

1982 • 391 citations

Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study

1976 • 257 citations

Combined 5-fluorouracil and radiation therapy as a surgical adjuvant for poor prognosis gastric carcinoma.

1984 • 217 citations

Combined Effect of X Radiation and 5-Fluorouracil on Survival of Transplanted Leukemic Cells<xref ref-type="fn" rid="FN1">2</xref>

1971 • 168 citations

5-Flourouracil metabolism monitored in vivo by 19F NMR

1984 • 163 citations

Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment.

1988 • 135 citations

Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy

1987 • 127 citations

Possible role of potentiators in radiation therapy.

1961 • 93 citations

Enhancement of mammalian cell killing by 5-fluorouracil in combination with X-rays.

1979 • 90 citations

Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy.

1990 • 71 citations

Effects of some Metabolic Inhibitors on X-ray Dose-response Curves for the Survival of Mammalian Cellsin vitro, and on Early Recovery between Fractionated X-ray Doses

1966 • 62 citations

Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.

1992 • 60 citations

Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo

1989 • 56 citations

5-fluorouracil infusions and fractionated doses of radiation: Studies with a murine squamous cell carcinoma

1987 • 50 citations

New approach to metabolism of 5?-deoxy-5-fluorouridine in humans with fluorine-19 NMR

1984 • 45 citations

In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues

1990 • 43 citations

Fluoropyrimidines as radiation sensitizers

1993 • 42 citations

19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver.

1991 • 34 citations

In vivo monitoring of changes in 5‐fluorouracil metabolism induced by methotrexate measured by ¹⁹F NMR spectroscopy

1991 • 29 citations

Locoregional administration of 5-fluoro-2′-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by19F-NMR spectroscopy

1991 • 29 citations

Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma

1986 • 27 citations

Radiosensitization of cultured human colon adenocarcinoma cells by 5-fluorouracil: Effects on cell survival, DNA repair, and cell recovery

1992 • 26 citations

Solid tumour models for the assessment of different treatment modalities: IV. the combined effects of radiation and 5-fluorouracil

1976 • 25 citations

Influence of Cell Cycle Phase on Radiation-Induced Cytotoxicity and DNA Damage in Human Colon Cancer (HT29) and Chinese Hamster Ovary Cells

1994 • 24 citations

Growth delay in a murine squamous cell tumor after local radiation and concurrent infusional 5-Fluorouracil treatment

1986 • 20 citations

Follow-up by 31P NMR spectroscopy of the energy metabolism of malignant tumor in rats during treatment

1991 • 11 citations