Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease

1980 • 269 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

1989 • 228 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.

1989 • 167 citations

Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels

1990 • 158 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Epidemiology of some peripheral arterial findings in diabetic men and women: Experiences from the Framingham study

1990 • 125 citations

Defective in vitro production of gamma-interferon and tumor necrosis factor-alpha by circulating T cells from patients with the hyper-immunoglobulin E syndrome.

1989 • 122 citations

Specific IgE antibodies in atopic eczema

1975 • 122 citations

Immunoregulatory abnormalities in atopic dermatitis

1986 • 86 citations

Atopic manifestations in the acquired immune deficiency syndrome: response to recombinant interferon gamma.

1987 • 85 citations

Generation and characterization of monoclonal antibodies specific for the human IFN-gamma receptor.

1988 • 78 citations

Induction of interleukin-4-dependent IgE synthesis and interleukin-5-dependent eosinophil differentiation by supernatants of a human helper T-cell clone

1988 • 62 citations

In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.

1983 • 46 citations

A biologic assay for IL-4 rapid fluorescence assay for IL-4 detection in supernatants and serum

1990 • 26 citations

Differential inhibition of T and B cell function in IL-4-dependent IgE production by cyclosporin A and methylprednisolone.

1990 • 23 citations

In vitro Synthesis of IgE by Human Peripheral Blood Leucocytes

1985 • 12 citations

383 Recombinant interferon-gamma (rIFN-γ) therapy reduces the clinical severity of atopic dermatitis (AD)

1991 • 7 citations