Metabolism and mechanisms of action of 9-(tetrahydro-2-furyl)-6-mercaptopurine in Chinese hamster ovary cells

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 284 citations

Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.

1975 • 240 citations

Antitumor Activity and Structural Relationships of Purine Derivatives and Related Compounds against Neoplasms in Experimental Animals

1964 • 78 citations

THE MECHANISM OF ACTION OF 3‐DEAZAURIDINE IN TUMOR CELLS SENSITIVE AND RESISTANT TO ARABINOSYLCYTOSINE^*

1975 • 74 citations

Synthesis and Antitumor Activity of 9-(Tetrahydro-2-furyl)purine Analogs of Biologically Important Deoxynucleosides¹

1963 • 65 citations

Approaches to the Combination Chemotherapy of Transplantable Neoplasms

2015 • 52 citations

Effects of 2-amino-1,3,4-thiadiazole on ribonucleotide pools of leukemia L1210 cells.

1976 • 46 citations

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine

1978 • 45 citations

Electrophoretic shift mutants in Chinese hamster ovary cells: evidence for genetic diploidy.

1978 • 37 citations

Conversion of 6-mercaptopurine and 6-mercaptopurine ribonucleoside to 6-methylmercaptopurine ribonucleotide in human epidermoid carcinoma No. 2. cells in culture

1966 • 35 citations

Potential Purine Antagonists. XXXI. The Preparation of Certain 9-Alkyl-2-amino-6-purinethiols and Related Derivatives as Antitumor Agents

1962 • 33 citations

Actions of 3-deazaguanine and 3-deazaguanosine on variant lines of Chinese hamster ovary cells

1981 • 29 citations

The effects of a series of 9-alkylpurines on the growth of sensitive and 6-MP-resistant H. Ep. 2 cells.

1962 • 27 citations

Prevention of the growth-inhibitory effect of 6-mercaptopurine by 4-amino-imidazole-5-carboxamide

1964 • 22 citations

Inhibition of hypoxanthine-guanine phosphoribosyl transferase

1979 • 18 citations

Use of enzyme-deficient cell culture lines as a biochemical screen for study of purines, purine nucleosides and related compounds

1973 • 16 citations

Metabolism of 9-beta-D-xylofuranosyladenine by the Chinese hamster ovary cell.

1981 • 7 citations

9-Ethyl-6-mercaptopurine (NSC-14575): preliminary clinical observations.

1962 • 4 citations

Lack of activity of beta-2'-deoxythioguanosine against two tumors resistant to 6-thioguanine.

1975 • 4 citations

DNA synthesis is essential for the expression of XYL-A toxicity in the CHO cell

1981 • 1 citations

Thiopurines in the treatment of acute childhood leukemia.

1968 • 1 citations