Identification of the Substrates and Interaction Proteins of Aurora Kinases from a Protein-Protein Interaction Model

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

A comprehensive two-hybrid analysis to explore the yeast protein interactome

2001 • 3,564 citations

STRING: a database of predicted functional associations between proteins

2003 • 2,327 citations

Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

2001 • 2,058 citations

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions

2002 • 1,709 citations

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

1999 • 1,661 citations

BIND--The Biomolecular Interaction Network Database

2001 • 1,591 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

2002 • 1,465 citations

BIND: the Biomolecular Interaction Network Database

2003 • 1,049 citations

A combined algorithm for genome-wide prediction of protein function

1999 • 921 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

Protein Interactions

2002 • 656 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae

2001 • 593 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

2000 • 534 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

1999 • 379 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

The Ndc80p Complex from Saccharomyces cerevisiae Contains Conserved Centromere Components and Has a Function in Chromosome Segregation

2001 • 318 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle.

1995 • 269 citations

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour

2001 • 267 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

2000 • 265 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4

1988 • 237 citations

Molecular Analysis of Kinetochore-Microtubule Attachment in Budding Yeast

2001 • 236 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo

2000 • 202 citations

Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins

2000 • 194 citations

The spindle pole body component Spc97p interacts with the gamma -tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication

1997 • 193 citations

A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos

1998 • 184 citations

InterDom: a database of putative interacting protein domains for validating predicted protein interactions and complexes

2003 • 160 citations

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae

2000 • 155 citations

Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

1999 • 149 citations

Mitotic Spindle Integrity and Kinetochore Function Linked by the Duo1p/Dam1p Complex

2001 • 147 citations

TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos

2003 • 141 citations

Sli15 Associates with the Ipl1 Protein Kinase to Promote Proper Chromosome Segregation in Saccharomyces cerevisiae

1999 • 139 citations

Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

1998 • 135 citations

Simple centromere, complex kinetochore

2002 • 134 citations

TAC-1, a Regulator of Microtubule Length in the C. elegans Embryo

2003 • 118 citations

Caenorhabditis elegans TAC-1 and ZYG-9 Form a Complex that Is Essential for Long Astral and Spindle Microtubules

2003 • 110 citations

The Yeast Spindle Pole Body Component Spc72p Interacts with Stu2p and Is Required for Proper Microtubule Assembly

1998 • 104 citations

MBD3 and HDAC1, Two Components of the NuRD Complex, Are Localized at Aurora-A-positive Centrosomes in M Phase

2002 • 61 citations

Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins

2000 • 50 citations

Identification of Aurora Kinases as RasGAP Src Homology 3 Domain-binding Proteins

2002 • 42 citations

Describing Biological Protein Interactions in Terms of Protein States and State Transitions

2002 • 40 citations

Yeast GAL4 Two-Hybrid System: A Genetic System to Identify Proteins That interact with a Target Protein

2003 • 23 citations