Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

Two functional components of the hippocampal memory system

1994 • 1,114 citations

Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.

1996 • 635 citations

Memory impaired aged rats: No loss of principal hippocampal and subicular neurons

1996 • 347 citations

Individual differences in aging: Behavioral and neurobiological correlates

1989 • 254 citations

Age and neurochemical correlates of radial maze performance in rats

1981 • 217 citations

Ageing: the cholinergic hypothesis of cognitive decline

1995 • 208 citations

The Effect of Aging on Experience-Dependent Plasticity of Hippocampal Place Cells

1997 • 205 citations

Survival, Integration, and Differentiation of Neural Stem Cell Lines after Transplantation to the Adult Rat Striatum

1997 • 191 citations

Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus

1997 • 178 citations

Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration

1995 • 161 citations

Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain

1995 • 158 citations

The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line

1995 • 138 citations

Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT

1990 • 120 citations

Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.

1996 • 117 citations

Cholinergic grafts in the neocortex or hippocampus of aged rats: Reduction of delay-dependent deficits in the delayed non-matching to position task

1988 • 108 citations

Conditionally Immortalized, Multipotential and Multifunctional Neural Stem Cell Lines as an Approach to Clinical Transplantation

2000 • 106 citations

Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field

1999 • 100 citations

Metabotropic Glutamate Receptor-Mediated Hippocampal Phosphoinositide Turnover Is Blunted in Spatial Learning-Impaired Aged Rats

1999 • 89 citations

Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging

1998 • 86 citations

Cholinergic markers in aged cognitively impaired long-evans rats

1995 • 80 citations

Polymer-Encapsulated Genetically Modified Cells Continue to Secrete Human Nerve Growth Factor for over One Year in Rat Ventricles: Behavioral and Anatomical Consequences

1996 • 76 citations

Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery

1995 • 74 citations

Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells

1999 • 64 citations

Comparison of effects of global cerebral ischaemia on spatial learning in the standard and radial water maze: relationship of hippocampal damage to performance

1997 • 60 citations

Neural transplantation and recovery of cognitive function

1995 • 46 citations

Functional Reconstruction of the Hippocampus: Fetal Versus Conditionally Immortal Neuroepithelial Stem Cell Grafts

2000 • 41 citations

Importance of forebrain cholinergic and GABAergic systems to the age-related deficits in water maze performance of rats

1995 • 37 citations

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions

2000 • 30 citations

Altered Sensitivity of α₂‐Adrenoceptors in the Brain during Aging in Rats^a

1992 • 7 citations

Deleted Work

1955 • 0 citations