Conditionally Immortalized, Multipotential and Multifunctional Neural Stem Cell Lines as an Approach to Clinical Transplantation

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Stem Cells in the Central Nervous System

1997 • 1,483 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Two functional components of the hippocampal memory system

1994 • 1,114 citations

Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

1992 • 928 citations

Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation

1996 • 834 citations

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.

1991 • 746 citations

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

1991 • 474 citations

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

1997 • 469 citations

Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

1997 • 439 citations

Establishment and characterization of multipotent neural cell lines using retrovirus vector‐mediated oncogene transfer

1990 • 375 citations

Magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medial temporal lobe and diencephalic amnesia

1990 • 322 citations

Functional neural transplantation

1995 • 278 citations

Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

1990 • 259 citations

Cholinergic-rich brain transplants reverse alcohol-induced memory deficits

1988 • 221 citations

Immortalized neural progenitor cells for CNS gene transfer and repair

1997 • 216 citations

Host-guided migration allows targeted introduction of neurons into the embryonic brain

1995 • 206 citations

Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze

1993 • 204 citations

Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6‐hydroxydopamine lesioned adult rats

1992 • 202 citations

Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle

1995 • 198 citations

Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus

1997 • 178 citations

Selective Hippocampal Lesions and Behavior

1986 • 173 citations

Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons

1994 • 171 citations

Striatal precursors adopt cortical identities in response to local cues

1995 • 164 citations

The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats

1991 • 142 citations

Neural-Targeted Gene Therapy for Rodent and Primate Hemiparkinsonism

1994 • 139 citations

Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe

1993 • 136 citations

Conditional learning and memory impairments following neurotoxic lesion of the CA1 field of the hippocampus

1995 • 125 citations

Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system—I. Amelioration of cognitive deficits by transplants into cortex and hippocampus but not into basal forebrain

1991 • 113 citations

Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons

1995 • 110 citations

Chronic memory impairment after cardiac arrest outside hospital

1996 • 106 citations

Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field

1999 • 100 citations

Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system—II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery

1991 • 97 citations

Bilateral lesions of CA1 and CA2 fields of the hippocampus are sufficient to cause a severe amnesic syndrome in humans.

1995 • 88 citations

Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischaemia in rats

1996 • 78 citations

Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery

1995 • 74 citations

Are the cognitive-enhancing effects of nicotine in the rat with lesions to the forebrain cholinergic projection system mediated by an interaction with the noradrenergic system?

1994 • 73 citations

A short term analysis of the behaviour of conditionally immortalized neuronal progenitors and primary neuroepithelial cells implanted into the fetal rat brain

1994 • 71 citations

The H-2KbtsA58 transgenic mouse: A new tool for the rapid generation of novel cell lines

1995 • 65 citations

Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells

1999 • 64 citations

Neuronal precursor cells in the rat hippocampal formation contribute to more than one cytoarchitectonic area

1992 • 48 citations

Neural transplantation and recovery of cognitive function

1995 • 46 citations

Immortalization of raphe neurons: an approach to neuronal function in vitro and in vivo

1992 • 38 citations

Lever pressing for food reward andin vivo voltammetry: Evidence for increases in extracellular homovanillic acid, the dopamine metabolite, and uric acid in the rat caudate nucleus

1989 • 30 citations

Immunocharacterization of H-2Kb-tSA58 transgenic mouse hippocampal neuroepithelial cells

1994 • 25 citations

Learning impairment induced by lesion of the CA1 field of the primate hippocampus: attempts to ameliorate the impairment by transplantation of fetal CA1 tissue

1997 • 23 citations

Changes in the Sensitivity of Frontal Cortical Neurones to Acetylcholine After Unilateral Lesion of the Nucleus Basalis with α-Amino-3-OH-4-Isoxozole Propionic Acid (AMPA): Effects of Basal Forebrain Transplants Into Neocortex

1997 • 9 citations

Behavioural Specificity of Neocortical Grafts of Fetal Basal Forebrain Tissue After Unilateral Lesion of the Nucleus Basalis with α -Amino-3-OH-4-Isoxozole Propionic Acid (AMPA)

1997 • 6 citations