Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

1992 • 928 citations

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

1988 • 508 citations

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

1991 • 474 citations

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

1993 • 441 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

NGF improves spatial memory in aged rodents as a function of age

1991 • 263 citations

Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1991 • 261 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat

1989 • 243 citations

Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression

1994 • 213 citations

Long-term correction of rat model of Parkinson's disease by gene therapy

1993 • 206 citations

Intracerebral grafting: A tool for the neurobiologist

1991 • 195 citations

Human nerve growth factor improves spatial memory in aged but not in young rats

1994 • 193 citations

A quantitative bioassay for nerve growth factor (NGF) activity employing a clonal pheochromocytoma cell line

1977 • 192 citations

Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.

1994 • 172 citations

Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats

1992 • 162 citations

Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons.

1994 • 154 citations

Genetically modified cells: applications for intracerebral grafting

1991 • 149 citations

CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomized cholinergic neurons after transplantation into the septum

1995 • 143 citations

Neural-Targeted Gene Therapy for Rodent and Primate Hemiparkinsonism

1994 • 139 citations

Transplantation of a Polymer-Encapsulated Cell Line Genetically Engineered to Release NGF

1993 • 129 citations

Spatial learning in rats: Correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage

1989 • 117 citations

Rescue of basal forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF

1990 • 114 citations

Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats

1993 • 100 citations

Grafting immortalized neurons to the CNS

1994 • 93 citations

Variable Morphological Differentiation of a Raphé-Derived Neuronal Cell Line Following Transplantation into the Adult Rat CNS

1993 • 91 citations

Delayed treatment with nerve growth factor improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: Evaluation of the involvement of different neurotransmitter systems

1992 • 80 citations

The use of genetically altered astrocytes to provide nerve growth factor to adrenal chromaffin cells grafted into the striatum

1991 • 78 citations

Nerve growth factors

1989 • 63 citations

Exogenous nerve growth factor stimulates choline acetyltransferase activity in aging Fischer 344 male rats

1991 • 60 citations

Genetically Modified Primary Astrocytes as Cellular Vehicles for Gene Therapy in the Brain

1993 • 60 citations

Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis

1994 • 55 citations

Exogenous Nerve Growth Factor Reverses Age-Related Structural Changes in Neocortical Neurons in the Aging Rat

1991 • 45 citations

Effect of delayed treatment with nerve growth factor on choline acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis: dose requirements

1992 • 40 citations

Nerve growth factor reverses spatial memory impairments in aged rats

1994 • 32 citations

Encapsulated genetically engineered fibroblasts: Release of nerve growth factor and effects in vivo on recovery of cholinergic markers after devascularizing cortical lesions

1994 • 31 citations

Intracerebral transplants of primary muscle cells: a potential ‘platform’ for transgene expression in the brain

1992 • 29 citations

Effects of brain-derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis

1994 • 23 citations

Effect of nerve growth factor on the lesioned septohippocampal cholinergic system of aged rats

1991 • 14 citations