Differential Effects of Heparin Saccharides on the Formation of Specific Fibroblast Growth Factor (FGF) and FGF Receptor Complexes

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

2000 • 679 citations

Regulated Diversity of Heparan Sulfate

1998 • 671 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Structural Basis for FGF Receptor Dimerization and Activation

1999 • 597 citations

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1998 • 543 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

Integral membrane heparan sulfate proteoglycans

1993 • 423 citations

The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function

1997 • 400 citations

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

1998 • 350 citations

Keratinocyte Growth Factor: A Unique Player in Epithelial Repair Processes

1998 • 345 citations

Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor

1996 • 287 citations

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

1995 • 277 citations

FGF Binding and FGF Receptor Activation by Synthetic Heparan-Derived Di- and Trisaccharides

1995 • 270 citations

Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.

1994 • 254 citations

Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for Receptor Dimerization

1994 • 239 citations

Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity

1992 • 236 citations

Structural interactions of fibroblast growth factor receptor with its ligands

2000 • 231 citations

An antagonist peptide–EPO receptor complex suggests that receptor dimerization is not sufficient for activation

1998 • 216 citations

Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides

1999 • 189 citations

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

1990 • 187 citations

Selectively Desulfated Heparin Inhibits Fibroblast Growth Factor-induced Mitogenicity and Angiogenesis

2000 • 174 citations

Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis.

1994 • 139 citations

Interaction of Heparan Sulfate from Mammary Cells with Acidic Fibroblast Growth Factor (FGF) and Basic FGF

1998 • 130 citations

Highly Sensitive Sequencing of the Sulfated Domains of Heparan Sulfate

1999 • 128 citations

Novel regio- and stereoselective modifications of heparin in alkaline solution. Nuclear magnetic resonance spectroscopic evidence

1989 • 128 citations

Fibroblast growth factor receptors display both common and distinct signaling pathways.

1995 • 125 citations

Basic Fibroblast Growth Factor Binds Its Receptors, Is Internalized, and Stimulates DNA Synthesis in Balb/c3T3 Cells in the Absence of Heparan Sulfate

1996 • 112 citations

[11] Regulation by heparan sulfate in fibroblast growth factor signaling

1994 • 106 citations

Identification of Glypican as a Dual Modulator of the Biological Activity of Fibroblast Growth Factors

1997 • 105 citations

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

1996 • 103 citations

Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2

1994 • 100 citations

Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.

1993 • 98 citations

Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants.

1993 • 96 citations

Properly Oriented Heparin−Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor^,

1997 • 95 citations

Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction

1995 • 89 citations

Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix

1992 • 89 citations

Studies on heparin degradation—I

1971 • 85 citations

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.

1994 • 75 citations

Increased Expression of Keratinocyte Growth Factor in Human Pancreatic Cancer

1995 • 59 citations

Monomer Complexes of Basic Fibroblast Growth Factor and Heparan Sulfate Oligosaccharides Are the Minimal Functional Unit for Cell Activation

1999 • 50 citations

Heparan Sulfate Proteoglycan Modulates Keratinocyte Growth Factor Signaling through Interaction with both Ligand and Receptor

1999 • 46 citations

Proteoglycan Protocols

2001 • 44 citations

Similarities and Differences between the Effects of Heparin and Glypican-1 on the Bioactivity of Acidic Fibroblast Growth Factor and the Keratinocyte Growth Factor

1999 • 44 citations

Novel regio- and stereoselective O-6-desulfation of the glucosamine moiety of heparin with N-methylpyrrolidinone–water or N,N-dimethylformamide–water mixtures11Abbreviations: I, α-l-idopyranosyluronic acid residue; A, 2-deoxy-2-sulfamido-α-d-glucopyranosyl residue. [A-6(OS)] refers to the 6-O-sulfo group of the 2-amino-2-deoxy-α-d-glucopyranosyl moiety, and [I-2(OS)] refers to the 2-O-sulfo group of the α-l-idopyranosyl-uronic acid moiety.

1998 • 43 citations

Epithelial-Mesenchymal Interactions in Cancer

1995 • 40 citations

Heparin Is Essential for a Single Keratinocyte Growth Factor Molecule To Bind and Form a Complex with Two Molecules of the Extracellular Domain of Its Receptor

1999 • 38 citations

Chimeric Molecules between Keratinocyte Growth Factor and Basic Fibroblast Growth Factor Define Domains That Confer Receptor Binding Specificities

1995 • 38 citations

Common and Specific Determinants for Fibroblast Growth Factors in the Ectodomain of the Receptor Kinase Complex

1998 • 30 citations

Molecular Modeling Based Mutagenesis Defines Ligand Binding and Specificity Determining Regions of Fibroblast Growth Factor Receptors

1995 • 26 citations

Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma

1997 • 23 citations

Optical Biosensor Techniques to Analyze Protein-Polysaccharide Interactions

2003 • 21 citations

Identification of Residues Important Both for Primary Receptor Binding and Specificity in Fibroblast Growth Factor-7

2000 • 19 citations

Mutations Uncouple Human Fibroblast Growth Factor (FGF)-7 Biological Activity and Receptor Binding and Support Broad Specificity in the Secondary Receptor Binding Site of FGFs

1999 • 18 citations