Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Methods in yeast genetics

1979 • 7,824 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The Genetics and Biology of Drosophila

1978 • 3,910 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

The Genetics and Biology of Drosophila

1976 • 1,427 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Life Span of Individual Yeast Cells

1959 • 754 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

1996 • 623 citations

An unusual form of transcriptional silencing in yeast ribosomal DNA.

1997 • 590 citations

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA

1989 • 550 citations

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

1996 • 541 citations

Spreading of transcriptional represser SIR3 from telomeric heterochromatin

1996 • 523 citations

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1995 • 496 citations

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

1993 • 463 citations

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.

1997 • 376 citations

Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae

1997 • 371 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

Interorganelle Signaling Is a Determinant of Longevity in Saccharomyces cerevisiae

1999 • 324 citations

Position-Effect Variegation

1968 • 319 citations

RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae.

1991 • 315 citations

Loss of Transcriptional Silencing Causes Sterility in Old Mother Cells of S. cerevisiae

1996 • 308 citations

Histone Deacetylase: A Regulator of Transcription

1996 • 298 citations

Silencers, silencing, and heritable transcriptional states

1992 • 296 citations

Position-effect variegation after 60 years

1990 • 286 citations

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA

1997 • 280 citations

[8] Putting the HO gene to work: Practical uses for mating-type switching

1991 • 254 citations

A position effect in the control of transcription at yeast mating type loci

1981 • 233 citations

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

1994 • 227 citations

A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors

1999 • 227 citations

Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae

1989 • 211 citations

Regulation of transcription in expressed and unexpressed mating type cassettes of yeast

1981 • 210 citations

Silencing and Heritable Domains of Gene Expression

1995 • 196 citations

Divergent roles of RAS1 and RAS2 in yeast longevity

1994 • 191 citations

Calendar life span versus budding lifespan of Saccharomyces cerevisiae

1980 • 173 citations

Notes: Point Mutations in the Yeast Histone H4 Gene Prevent Silencing of the Silent Mating Type Locus HML

1990 • 168 citations

Distribution of a Limited Sir2 Protein Pool Regulates the Strength of Yeast rDNA Silencing and Is Modulated by Sir4p

1998 • 160 citations

Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci.

1992 • 120 citations

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

1990 • 108 citations

RPD3 Encodes a Second Factor Required To Achieve Maximum Positive and Negative Transcriptional States in Saccharomyces cerevisiae

1991 • 106 citations

Preparation and Partial Characterization of Old Yeast Cells

1990 • 106 citations

Telomere length constancy during aging of Saccharomyces cerevisiae

1991 • 96 citations

Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus.

1996 • 89 citations

A useful colony colour phenotype associated with the yeast selectable/counter-selectable marker MET15

1996 • 82 citations

A Polymerase Switch in the Synthesis of rRNA in Saccharomyces cerevisiae

1995 • 79 citations

Silencers, silencing, and heritable transcriptional states.

1992 • 78 citations

Effect of Replicative Age on Transcriptional Silencing Near Telomeres inSaccharomyces cerevisiae

1996 • 75 citations

Evidence That the Transcriptional Regulators SIN3 and RPD3, and a Novel Gene (SDS3) with Similar Functions, Are Involved in Transcriptional Silencing in S. cerevisiae

1996 • 73 citations

Parental age and the life-span of zygotes of Saccharomyces cerevisiae

1985 • 70 citations

Epigenetic stratification: the role of individual change in the biological aging process

1998 • 62 citations

Specific Alterations in Transcript Prevalence During the Yeast Life Span

1989 • 60 citations

Prolongation of the yeast life span by the v‐Ha‐RAS oncogene

1990 • 56 citations

Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.

1995 • 39 citations

The effect of aging on protein synthesis in the yeast Saccharomyces cerevisiae

1992 • 35 citations

Experimentation with the Yeast Model

1998 • 19 citations