Therapeutic targeting of B7-H1 in breast cancer

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

2005 • 7,244 citations

pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

1991 • 5,979 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

RNA interference

2002 • 3,369 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

2010 • 2,721 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

1999 • 2,156 citations

Inhibitory B7-family molecules in the tumour microenvironment

2008 • 1,511 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Molecular Definition of Breast Tumor Heterogeneity

2007 • 1,338 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺T lymphocytes are prognostic factors of human ovarian cancer

2007 • 1,317 citations

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

2006 • 1,254 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 • 1,118 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

2007 • 843 citations

Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up

2006 • 826 citations

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

2006 • 798 citations

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody

2010 • 767 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

Trends in Breast Cancer by Race and Ethnicity: Update 2006

2006 • 721 citations

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

2009 • 694 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

2005 • 602 citations

Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy

2004 • 571 citations

The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors

2006 • 570 citations

Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway

2007 • 553 citations

In Breast Carcinoma Tissue, Immature Dendritic Cells Reside within the Tumor, Whereas Mature Dendritic Cells Are Located in Peritumoral Areas

1999 • 540 citations

Toll-Like Receptors on Tumor Cells Facilitate Evasion of Immune Surveillance

2005 • 531 citations

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

2008 • 480 citations

Trends in Breast Cancer by Race and Ethnicity

2003 • 459 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

Dendritic cell maturation by innate lymphocytes

2005 • 390 citations

Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis

2003 • 370 citations

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3 ⁺ CD4 ⁺ regulatory T cells

2008 • 370 citations

Pattern of distribution of cells positive for estrogen receptor α and progesterone receptor in relation to proliferating cells in the mammary gland

1999 • 356 citations

The B7 Family and Cancer Therapy: Costimulation and Coinhibition

2007 • 326 citations

Blockade of PD‐L1 (B7‐H1) augments human tumor‐specific T cell responses in vitro

2006 • 292 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction

2002 • 280 citations

PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion Vaccine

2011 • 278 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis

2004 • 269 citations

Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis

2007 • 245 citations

Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+ T-Cell Infiltration and Survival of Patients with Cervical Carcinoma

2009 • 241 citations

Time-dependence of hazard ratios for prognostic factors in primary breast cancer

1998 • 229 citations

Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule

2010 • 216 citations

B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts

2006 • 202 citations

PD-1 on dendritic cells impedes innate immunity against bacterial infection

2009 • 195 citations

FOXP3+ Tregs and B7-H1+/PD-1+T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy

2008 • 194 citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

2003 • 185 citations

Contribution of the PD‐1 ligands/PD‐1 signaling pathway to dendritic cell‐mediated CD4⁺ T cell activation

2006 • 179 citations

Regulated Compartmentalization of Programmed Cell Death-1 Discriminates CD4+CD25+ Resting Regulatory T Cells from Activated T Cells

2006 • 170 citations

Reduced T-Cell and Dendritic Cell Function Is Related to Cyclooxygenase-2 Overexpression and Prostaglandin E2 Secretion in Patients With Breast Cancer

2004 • 167 citations

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

2008 • 166 citations

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

2010 • 154 citations

High PD-L1/CD86 Ratio on Plasmacytoid Dendritic Cells Correlates With Elevated T-Regulatory Cells in Liver Transplant Tolerance

2008 • 150 citations

Expression of B7‐H1 in breast cancer patients is strongly associated with high proliferative Ki‐67‐expressing tumor cells

2007 • 146 citations

Involvement of the Programmed Death-1/Programmed Death-1 Ligand Pathway in CD4+CD25+ Regulatory T-Cell Activity to Suppress Alloimmune Responses

2007 • 131 citations

NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells

2004 • 119 citations

Immunogenicity of anthracyclines: moving towards more personalized medicine

2008 • 112 citations

PD‐1/B7‐H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft

2009 • 107 citations

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

2010 • 98 citations

Evidence for immune defects in breast and lung cancer patients

2004 • 95 citations

Interleukin‐17‐educated monocytes suppress cytotoxic T‐cell function through B7‐H1 in hepatocellular carcinoma patients

2011 • 88 citations

Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression.

1973 • 84 citations

Honokiol-mediated Inhibition of PI3K/mTOR Pathway

2009 • 84 citations

Tumor Cell Programmed Death Ligand 1-Mediated T Cell Suppression Is Overcome by Coexpression of CD80

2011 • 83 citations

The biology of neoadjuvant chemotherapy for breast cancer.

2002 • 79 citations

Vaccine and antibody-directed T cell tumour immunotherapy

2004 • 76 citations

Induction of peripheral CD4⁺ T‐cell tolerance and CD8⁺ T‐cell cross‐tolerance by dendritic cells

2009 • 75 citations

Targeting Molecular and Cellular Inhibitory Mechanisms for Improvement of Antitumor Memory Responses Reactivated by Tumor Cell Vaccine

2007 • 71 citations

Heavy Chain Ferritin siRNA Delivered by Cationic Liposomes Increases Sensitivity of Cancer Cells to Chemotherapeutic Agents

2011 • 70 citations

Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer

2007 • 69 citations

Adriamycin-activated macrophages as tumor growth inhibitors.

1981 • 67 citations

Adriamycin-induced modulation of host defenses in tumor-bearing mice.

1992 • 63 citations

Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

2011 • 59 citations

Dual Control of Antitumor CD8 T Cells through the Programmed Death-1/Programmed Death-Ligand 1 Pathway and Immunosuppressive CD4 T Cells: Regulation and Counterregulation

2009 • 56 citations

Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response

2005 • 54 citations

Triptolide inhibits interferon-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells

2008 • 53 citations

Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell

2006 • 52 citations

Cytosine arabinoside induces costimulatory molecule expression in acute myeloid leukemia cells

2004 • 50 citations

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells

2010 • 49 citations

Cellular basis for adriamycin-induced augmentation of cell-mediated cytotoxicity in culture.

1984 • 48 citations

Vaccine immunotherapy in breast cancer treatment: promising, but still early

2007 • 39 citations

Nimesulide inhibits IFN-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms

2008 • 38 citations

PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity

2010 • 33 citations

Tumour cells resistance in cancer therapy

2007 • 29 citations

[Expression and significance of B7-H1 and its receptor PD-1 in human gastric carcinoma].

2008 • 23 citations

Importance of the B7-2 Molecule for Low Dose Melphalan-Induced Acquisition of Tumor-Eradicating Immunity by Mice Bearing a Large MOPC-315 Tumor

1998 • 22 citations

Regulating immunity and inhibiting tumor growth by the recombinant peptide sPD-1-CH50.

2009 • 21 citations

[Expression and significance of PD-L1 in laryngocarcinoma].

2008 • 6 citations

Deleted Work

1955 • 0 citations