B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Tumour-cell invasion and migration: diversity and escape mechanisms

2003 • 3,069 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.

1996 • 985 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 • 644 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1998 • 496 citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

2003 • 481 citations

Natural history of HLA expression during tumour development

1993 • 448 citations

Nature's TRAIL—On a Path to Cancer Immunotherapy

2003 • 361 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

Delivering the kiss of death: progress on understanding how perforin works

2007 • 250 citations

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy

2007 • 237 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 215 citations

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

2007 • 187 citations

Gene Transfer of Programmed Death Ligand-1.Ig Prolongs Cardiac Allograft Survival

2006 • 43 citations