Functional Characterization of a Non-AUUUA AU-Rich Element from the c-jun Proto-Oncogene mRNA: Evidence for a Novel Class of AU-Rich Elements

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

PCR Protocols-A Guide to Methods and Applications

1991 • 1,272 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

1989 • 618 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

1994 • 331 citations

RECOMBINANT PCR

1990 • 294 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

Selective Degradation of Early-Response-Gene mRNAs: Functional Analyses of Sequence Features of the AU-Rich Elements

1994 • 253 citations

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function

1994 • 184 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.

1994 • 165 citations

Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region Is Mediated by a Cotranslational Mechanism

1993 • 131 citations

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.

1991 • 127 citations

Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.

1994 • 109 citations

Number and location of AUUUA motifs: role in regulating transiently expressed RNAs

1994 • 92 citations

Rapid Degradation of AU-Rich Element (ARE) mRNAs Is Activated by Ribosome Transit and Blocked by Secondary Structure at Any Position 5′ to the ARE

1995 • 76 citations

Rapid mRNA Degradation Mediated by the c-fos 3′ AU-Rich Element and That Mediated by the Granulocyte-Macrophage Colony-Stimulating Factor 3′ AU-Rich Element Occur through Similar Polysome-Associated Mechanisms

1995 • 57 citations

Interleukin-3 mRNA Stabilization by a trans-Acting Mechanism in Autocrine Tumors Lacking Interleukin-3 Gene Rearrangements

1995 • 36 citations