Multiple second messenger pathways regulate IL‐β‐induced expression of PGHS‐2 mRNA in normal human skin fibroblasts

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

1991 • 580 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Prostanoid biosynthesis and mechanisms of action

1992 • 551 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

1976 • 435 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme

1989 • 333 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.

1992 • 230 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.

1992 • 212 citations

Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′-flanking regulatory sequences

1992 • 210 citations

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.

1993 • 171 citations

Evidence for Two Antigenically Distinct Molecular Weight Variants of Prostaglandin HSynthase in the Rat Ovary

1991 • 154 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Structural Determination and Promoter Analysis of the Chicken Mitogen-Inducible Prostaglandin G/H Synthase Gene and Genetic Mapping of the Murine Homolog

1993 • 127 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

Characterization of the Promoter of Human Prostaglandin H Synthase-1 Gene

1993 • 106 citations

Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.

1992 • 97 citations

Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1.

1989 • 86 citations

Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids

1992 • 82 citations

Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.

1990 • 82 citations

Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction

1991 • 79 citations

Interleukin 1 release by human alveolar macrophages and blood monocytes

1989 • 77 citations

Hydroxyeicosatetraenoic acid metabolism in cultured human skin fibroblasts. Evidence for peroxisomal beta-oxidation.

1990 • 54 citations

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

1991 • 53 citations

Regulation of Prostaglandin Endoperoxide Synthase Gene Expression in Cultured Rat Mesangial Cells: Induction by Serum via a Protein Kinase-C-Dependent Mechanism

1991 • 48 citations

Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester

1992 • 33 citations

A rapid nuclear runoff transcription assay.

1993 • 27 citations

Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester: mediation by protein kinase C.

1991 • 22 citations

Regulation of prostanoids synthesis in human fibroblasts and human blood monocytes by interleukin-1, endotoxin, and glucocorticoids.

1990 • 16 citations

Identification of a highly conserved 3′ UTR in the translationally regulated mRNA for prostaglandin synthase

1990 • 14 citations

Serum induction and superinduction of PGG/H synthase mRNA levels in 3T3 fibroblasts.

1991 • 13 citations

Induction of gene expression by IL-1 in NIH 3T3 cells. Possible requirement of protein kinase C activity and independence from arachidonic acid metabolism.

1990 • 12 citations

Genetic conservation of cyclo-oxygenase

1991 • 10 citations

Elevated cAMP is required for stimulation of eicosanoid synthesis by interleukin 1 and bradykinin in BALB/c 3T3 fibroblasts

1992 • 7 citations

Attenuated prostaglandin formation in peroxisomal-deficient human skin fibroblasts.

1993 • 5 citations

Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells

1990 • 4 citations