Microallelotyping defines the sequence and tempo of alleiic losses at tumour suppressor gene loci during colorectal cancer progression

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer

1994 • 708 citations

SAMPLE PREPARATION FROM PARAFFIN-EMBEDDED TISSUES

1990 • 565 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER

1989 • 306 citations

Monoclonal antibodies define differential ras gene expression in malignant and benign colonic diseases

1984 • 226 citations

Randomised Comparison of Cisplatin with Cyclophosphamide/Cisplatin and with Cyclophosphamide/Doxorubicin/Cisplatin in Advanced Ovarian Cancer

1988 • 218 citations

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 182 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas.

1991 • 159 citations

Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci

1990 • 152 citations

Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma

1988 • 147 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

A CA repeat 30–70 Kb downstream from the adenomatous polyposis coli (APC) gene

1992 • 136 citations

Chromosomal banding patterns in human large bowel cancer

1981 • 130 citations

Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry.

1986 • 115 citations

Type and number of Ki-ras point mutations relate to stage of human colorectal cancer.

1994 • 111 citations

A frequent alteration of p53 gene in carcinoma in adenoma of colon.

1994 • 105 citations

An Alu polymorphism intragenic to the TP53 gene

1991 • 104 citations

Removal of inhibitor(s) of the polymerase chain reaction from formalin fixed, paraffin wax embedded tissues.

1991 • 101 citations

A CA repeat 30 – 70 KB downstream from the adenomatous polyposis coli (APC) gene

1991 • 96 citations

Dinucleotide repeat polymorphism at the D18S34 locus

1990 • 27 citations

Dinucleotide repeat polymorphism at the D17S514 locus

1991 • 20 citations

A developmental context for multiple genetic alterations in Wilms’ tumor

1994 • 19 citations

Dinucleotide repeat polymorphism at the D18S35 locus

1990 • 19 citations

Dinucleotide repeat polymorphism at the D17S513 locus

1991 • 18 citations

Transitional mucosa of the colon and tumor growth factors

1987 • 13 citations

A glycine to serine polymorphism in the C-propeptide of the human type II procollagen

1990 • 9 citations