HeterozygousAprt mouse model: Detection and study of a broad range of autosomal somatic mutations in vivo

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

The multistep nature of cancer

1993 • 1,872 citations

Antioncogenes and human cancer.

1993 • 772 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Multicolour spectral karyotyping of mouse chromosomes

1996 • 313 citations

Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.

1990 • 152 citations

High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.

1997 • 120 citations

Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis.

1996 • 120 citations

Loss of Heterozygosity or: How I Learned to Stop Worrying and Love Mitotic Recombination

1997 • 119 citations

Contribution of O⁶‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

1993 • 112 citations

The structure of mutation in mammalian cells

1990 • 101 citations

Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3

1999 • 76 citations

Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following in vivo inhalation exposure to 1,3-butadiene

1994 • 65 citations

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice

1998 • 61 citations

Other transgenic mutation assays:APRT: A versatile in vivo resident reporter of local mutation and loss of heterozygosity

1996 • 58 citations

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population

1992 • 52 citations

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse

1998 • 51 citations

Tk+/− mouse model for detecting in vivo mutation in an endogenous, autosomal gene

1999 • 45 citations

Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms

1998 • 40 citations

Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

1990 • 29 citations

Diagnosis of heterozygous states for adenine phosphoribosyltransferase deficiency based on detection of in vivo somatic mutants in blood T cells: application to screening of heterozygotes.

1991 • 25 citations

Inhibitors of DNA synthesis induce sister chromatid exchanges at the early S phase of the cell cycle

1984 • 25 citations

Mice with Adenine Phosphoribosyltransferase Deficiency Develop Fatal 2,8-Dihydroxyadenine Lithiasis

1996 • 23 citations

Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms.

1990 • 16 citations

Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus

1997 • 2 citations