PANTHER: A Library of Protein Families and Subfamilies Indexed by Function

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Pfam protein families database.

2002 • 14,298 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Measuring the Accuracy of Diagnostic Systems

1988 • 9,129 citations

dbSNP: the NCBI database of genetic variation

2001 • 6,995 citations

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

1999 • 3,156 citations

The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

2000 • 2,834 citations

Predicting Deleterious Amino Acid Substitutions

2001 • 2,513 citations

Amino Acid Difference Formula to Help Explain Protein Evolution

1974 • 2,255 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Hidden Markov models

1996 • 1,313 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

Pfam: A comprehensive database of protein domain families based on seed alignments

1997 • 1,211 citations

Hidden Markov models for detecting remote protein homologies.

1998 • 1,122 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

The TIGRFAMs database of protein families

2003 • 941 citations

RefSeq and LocusLink: NCBI gene-centered resources

2001 • 899 citations

The Pfam Protein Families Database

2002 • 785 citations

Accounting for Human Polymorphisms Predicted to Affect Protein Function

2002 • 700 citations

Recent improvements to the SMART domain-based sequence annotation resource

2002 • 685 citations

PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification

2003 • 629 citations

The human gene mutation database

1998 • 607 citations

Prosite: a dictionary of sites and patterns in proteins

1991 • 497 citations

Automated assembly of protein blocks for database searching

1991 • 465 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

Performance evaluation of amino acid substitution matrices

1993 • 448 citations

Hidden Markov models for sequence analysis: extension and analysis of the basic method

1996 • 448 citations

Position-based sequence weights

1994 • 422 citations

Dirichlet mixtures: a method for improved detection of weak but significant protein sequence homology

1996 • 338 citations

The human gene mutation database

1997 • 267 citations

Analysis and prediction of functional sub-types from protein sequence alignments

2000 • 254 citations

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI

2000 • 247 citations

Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses

1985 • 242 citations

MIPS: a database for protein sequences, homology data and yeast genome information

1997 • 231 citations

Predicting protein structure using hidden Markov models

1997 • 156 citations

Allelic and locus heterogeneity in inherited venous malformations

1999 • 130 citations

PRINTS--a database of protein motif fingerprints.

1994 • 124 citations

Phylogenetic inference in protein superfamilies: analysis of SH2 domains.

1998 • 65 citations

Assessment of Genome-Wide Protein Function Classification for Drosophila melanogaster

2003 • 45 citations

Representations of metabolic knowledge.

1993 • 41 citations

Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2–12: Evolutionary relatedness of cytokines clustered at the same locus

1991 • 35 citations

Inferences from protein and nucleic acid sequences: Early molecular evolution, divergence of kingdoms and rates of change

1974 • 33 citations

Predicting protein structure using hidden Markov models

1997 • 4 citations