Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies
Data up to Jan 2025
Total Citations Per Year
Abstract
References (127)
Bias in meta-analysis detected by a simple, graphical test
1997 • 47,526 citations
Meta-analysis in clinical trials
1986 • 36,193 citations
Statistical Methods for Meta-Analysis
1988 • 10,595 citations
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
1995 • 3,645 citations
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease
1991 • 2,191 citations
Homocysteine and Cardiovascular Disease
1998 • 2,177 citations
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
1992 • 2,163 citations
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.
1969 • 1,846 citations
Plasma Homocysteine as a Risk Factor for Vascular Disease
1997 • 1,770 citations
A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians
1992 • 1,686 citations
Summing up: The Science of Reviewing Research
1987 • 1,530 citations
Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis
1995 • 1,244 citations
Total homocysteine in plasma or serum: methods and clinical applications
1993 • 996 citations
Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence
1999 • 933 citations
Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
1995 • 899 citations
The Medical Review Article: State of the Science
1987 • 859 citations
Processing Data for Outliers
1953 • 849 citations
Validation of an index of the quality of review articles
1991 • 794 citations
Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease
1985 • 739 citations
Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine study
1996 • 678 citations
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
1996 • 670 citations
Serum Total Homocysteine and Coronary Heart Disease
1995 • 668 citations
Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, Related Genetic Polymorphisms, and B Vitamins
1998 • 616 citations
Low Circulating Folate and Vitamin B 6 Concentrations
1998 • 560 citations
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
1994 • 540 citations
The pathogenesis of coronary artery disease. A possible role for methionine metabolism.
1976 • 535 citations
Invited Commentary: A Critical Look at Some Popular Meta-Analytic Methods
1994 • 516 citations
Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians
1996 • 496 citations
Hyperhomocyst(e)inemia Is a Risk Factor for Arterial Endothelial Dysfunction in Humans
1997 • 495 citations
Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern Ireland
1962 • 494 citations
Homocysteine Metabolism and Risk of Myocardial Infarction: Relation with Vitamins B6, B12, and Folate
1996 • 493 citations
Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.
1993 • 460 citations
Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study
1999 • 443 citations
Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus
1996 • 423 citations
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project
1997 • 404 citations
Hyperhomocysteinemia and Low Pyridoxal Phosphate
1995 • 401 citations
Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment
1990 • 397 citations
Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease
1994 • 386 citations
A prospective study of plasma homocyst(e)ine and risk of ischemic stroke.
1994 • 386 citations
Homocysteine and Ischemic Heart Disease
1998 • 377 citations
Hyperhomocysteinemia Is Associated With an Increased Risk of Cardiovascular Disease, Especially in Non–Insulin-Dependent Diabetes Mellitus
1998 • 366 citations
Homocyst(e)ine and Risk of Cardiovascular Disease in the Multiple Risk Factor Intervention Trial
1997 • 359 citations
Nonfasting Plasma Total Homocysteine Levels and All-Cause and Cardiovascular Disease Mortality in Elderly Framingham Men and Women
1999 • 334 citations
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
1992 • 329 citations
Risk Factors Related to Carotid Intima-Media Thickness and Plaque in Children With Familial Hypercholesterolemia and Control Subjects
1996 • 327 citations
Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.
1986 • 307 citations
Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease
2000 • 304 citations
Elevated Fasting Total Plasma Homocysteine Levels and Cardiovascular Disease Outcomes in Maintenance Dialysis Patients
1997 • 299 citations
Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.
1984 • 290 citations
A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians.
1996 • 274 citations
An evaluation of homogeneity tests in meta-analyses in pain using simulations of individual patient data
2000 • 270 citations
Homocysteine and Short-term Risk of Myocardial Infarction and Stroke in the Elderly
1999 • 265 citations
Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors
1992 • 261 citations
Homocysteine and Risk of Cardiovascular Disease Among Postmenopausal Women
1999 • 260 citations
The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease
1991 • 250 citations
Plasma Total Homocysteine, B Vitamins, and Risk of Coronary Atherosclerosis
1997 • 247 citations
Homocysteine and Risk of Premature Coronary Heart Disease
1996 • 242 citations
Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase Gene
1997 • 233 citations
Common Mutation in Methylenetetrahydrofolate Reductase
1996 • 226 citations
Plasma Homocysteine and Coronary Heart Disease: Systematic Review of Published Epidemiological Studies
1998 • 222 citations
Plasma Homocysteine in the Acute and Convalescent Phases After Stroke
1995 • 219 citations
Meta-analyses to evaluate analgesic interventions: A systematic qualitative review of their methodology
1996 • 214 citations
Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction
1998 • 213 citations
Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acid
1995 • 212 citations
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
1993 • 208 citations
Plasma Homocysteine as a Risk Factor for Vascular Disease
1998 • 207 citations
Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects
1989 • 197 citations
Homocysteine and coronary artery disease in French Canadian subjects: Relation with vitamins B12, B6, pyridoxal phosphate, and folate
1995 • 197 citations
Homocysteine and myocardial infarction
1988 • 197 citations
Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease
1994 • 180 citations
A Common Polymorphism in the Methylenetetrahydrofolate Reductase Gene, Homocysteine, and Ischemic Cerebrovascular Disease
1997 • 178 citations
Serum Homocysteine and Risk of Coronary Heart Disease and Cerebrovascular Disease in Elderly Men
1998 • 176 citations
Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies
1998 • 175 citations
Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients
1995 • 162 citations
Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease
1996 • 152 citations
Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men.
1994 • 150 citations
Prevalence of familial hyperhomocyst(e)inemia in men with premature coronary artery disease.
1991 • 147 citations
Total Homocyst(e)ine Concentration and the Likelihood of Nonfatal Stroke
1998 • 144 citations
Methionine intolerance: A possible risk factor for coronary artery disease
1985 • 144 citations
Relation of Plasma Homocyst(e)ine to Cerebral Infarction and Cerebral Atherosclerosis
1998 • 142 citations
Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria
1983 • 138 citations
Homocyst(e)inemia in daily practice
1990 • 135 citations
Serum total homocysteine and coronary heart disease: prospective study in middle aged men
1999 • 129 citations
The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary heart disease
1991 • 124 citations
Plasma homocysteine concentration predicts mortality in non-insulin-dependent diabetic patients with and without albuminuria
1999 • 123 citations
Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam Study
1997 • 117 citations
Homocysteine and ischaemic heart disease in the Caerphilly cohort
1998 • 116 citations
Low Whole-Blood S -Adenosylmethionine and Correlation Between 5-Methyltetrahydrofolate and Homocysteine in Coronary Artery Disease
1996 • 103 citations
Plasma Total Homocysteine and Risk of Angina Pectoris With Subsequent Coronary Artery Bypass Surgery
1997 • 103 citations
Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease
1996 • 103 citations
Homocyst(e)ine and Coronary Artery Disease
1997 • 100 citations
Correlation between plasma homocyst(e)ine and aortic atherosclerosis
1997 • 90 citations
Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease
1995 • 89 citations
Features, Symptoms, and Neurophysiological Findings in Stroke Associated With Hyperhomocysteinemia
1997 • 86 citations
Plasma homocysteine and the extent of atherosclerosis in patients with coronary artery disease
1997 • 81 citations
Homocysteine Metabolism: From Basic Science to Clinical Medicine
1997 • 73 citations
Hyperhomocysteinemia and Hypofibrinolysis in Young Adults With Ischemic Stroke
1999 • 69 citations
Disordered methionine/homocysteine metabolism in premature vascular disease
1994 • 63 citations
Prospective Studies of Homocysteine and Cardiovascular Disease
2009 • 61 citations
Homocysteine in frozen plasma samples. A short cut to establish hyperhomocysteinaemia as a risk factor for arteriosclerosis?
1993 • 58 citations
Mild Hyperhomocysteinemia and Hemostatic Factors in Patients with Arterial Vascular Diseases
1997 • 51 citations
Hyperhomocysteinaemia and premature coronary artery disease in the Chinese.
1996 • 47 citations
Homocyst(e)ine and coronary artery disease
1992 • 43 citations
Plasma homocysteine levels in patients with coronary heart disease.
1998 • 43 citations
Association between plasma homocysteine and extracranial carotid arterial disease in oldor persons
1997 • 39 citations
Relationship among Homocyst(e)ine, Vitamin B-12 and Cardiac Disease in the Elderly: Association between Vitamin B-12 Deficiency and Decreased Left Ventricular Ejection Fraction
1996 • 35 citations
Association Between Plasma Homocysteine and Coronary Artery Disease in Older Persons
1997 • 31 citations
Moderate Hyperhomocyst(e)inemia Is Associated with the Presence of Coronary Artery Disease and the Severity of Coronary Atherosclerosis in Koreans
1999 • 30 citations
Family history and premature coronary heart disease.
1996 • 30 citations
Abnormalities of hemostasis in ischemic stroke
1993 • 28 citations
Total plasma homocysteine determination by liquid chromatography before and after methionine loading
1997 • 23 citations
The Diagnostic Value of Serum Homocysteine Concentration as a Risk Factor for Coronary Artery Disease
1998 • 20 citations
Hyperhomocysteinaemia in Black patients with cerebral thrombosis
1997 • 16 citations
Homocysteine Levels and Coronary Heart Disease in Syria
1998 • 15 citations
Marginal Folate Deficiency as a Possible Cause of Hyperhomocysteinaemia in Stroke Patients
1997 • 14 citations
Association between hyperhomocysteinemia and ischemic heart disease in Sri Lankans
1997 • 14 citations
[Plasma homocysteine levels in patients with ischemic cerebral infarction].
1998 • 13 citations
[Hyperhomocysteinemia in coronary artery diseases. Apropos of a study on 102 patients].
1996 • 13 citations
Influence of hydrolysis on plasma homocysteine determination in healthy subjects and patients with myocardial infarction
1991 • 13 citations
Total plasma homocysteine determination in subjects with premature cerebral vascular disease
1991 • 12 citations
Homocysteine levels and coronary heart disease in Syria
1998 • 11 citations
Homocysteinaemia after methionine overload as a coronary artery disease risk factor: importance of age and homocysteine levels.
1995 • 7 citations
Fitting Parametric Fixed Effect Models to Effect Sizes: Categorical Models
1985 • 4 citations
Evaluation of the Measurement of Lysate Homocysteine in Patients with Symptomatic Arterial Disease and in Healthy Volunteers
1999 • 3 citations
[Blood levels of homocysteine in patients under 55 years of age with acute coronary insufficiency].
1997 • 2 citations
A homocisteinemia como factor de risco de doença vascular cerebral. A importância da idade e dos nìveis de homocisteinemia.
1996 • 1 citations
A homocisteinemia como factor de risco de doença vascular cerebral
1996 • 1 citations