Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains.

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

The soluble interleukin‐6 receptor is generated by shedding

1993 • 502 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 419 citations

The Treatment of Multiple Myeloma

1994 • 409 citations

Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

1970 • 375 citations

Plasma cell myeloma--new biological insights and advances in therapy

1989 • 299 citations

Plasma cell myeloma--new biological insights and advances in therapy

1989 • 263 citations

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

1993 • 233 citations

Response patterns of purified myeloma cells to hematopoietic growth factors

1989 • 231 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.

1989 • 179 citations

Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266

1991 • 177 citations

Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma.

1989 • 163 citations

Interleukin 6 gene expression in normal and neoplastic B cells.

1989 • 153 citations

Interleukin-6 is a prognostic factor in multiple myeloma [letter] [see comments]

1991 • 145 citations

Identification of immature and mature myeloma cells in the bone marrow of human myelomas

1993 • 145 citations

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

1989 • 141 citations

Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells

1993 • 141 citations

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

1990 • 138 citations

Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

1994 • 131 citations

Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes.

1989 • 129 citations

Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia

1989 • 126 citations

Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells [see comments]

1990 • 125 citations

Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines.

1991 • 123 citations

Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.

1991 • 118 citations

COOH-Terminal-Modified Interleukin-3 Is Retained Intracellularly and Stimulates Autocrine Growth

1989 • 117 citations

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.

1991 • 105 citations

Anti‐human interleukin‐6 receptor antibody inhibits human myeloma growth in vivo

1992 • 99 citations

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1991 • 91 citations

gamma-Interferon in multiple myeloma: inhibition of interleukin-6 (IL- 6)-dependent myeloma cell growth and downregulation of IL-6-receptor expression in vitro

1993 • 83 citations

IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).

1990 • 80 citations

Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders.

1990 • 76 citations

Autocrine growth factors and tumourigenic transformation

1990 • 75 citations

Phenotypic analysis of human myeloma cell lines

1989 • 74 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 66 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression.

1991 • 65 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression

1991 • 54 citations

Dynamics of interleukin-6 internalization and degradation in rat hepatocytes.

1992 • 52 citations

Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA in a panel of established human multiple myeloma cell lines.

1991 • 48 citations

Differential regulation of interleukin-6 receptor and gp130 gene expression in rat hepatocytes.

1992 • 47 citations

Increase in interleukin 6 (IL-6) and IL-6 receptor expression in a human multiple myeloma cell line, U-266, during long-term in vitro culture and the development of a possible autocrine IL-6 loop.

1992 • 46 citations

Recombinant interferon‐ γ inhibits the growth of IL‐6‐dependent human multiple myeloma cell lines in vitro

1991 • 46 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 40 citations

A Functional Protein Kinase C Is Required for Induction of 2-5A Synthetase by Recombinant Interferon-αA in Daudi Cells

1989 • 32 citations

The effect of α and γ‐interferon on proliferation and production of IgE and β₂‐microglobulin in the human myeloma cell line U‐266 and in an α‐interferon resistant U‐266 subline

1986 • 26 citations

Differential regulation of interleukin‐6 receptors by interleukin‐6 and interferons in multiple myeloma cell lines

1994 • 22 citations

Modulation of Interferon-α and Interferon-γ Receptor Expression during T-Lymphocyte Activation and Proliferation

1986 • 22 citations

The Role of Interferon-α in the Management of Myelomatosis

1992 • 22 citations

Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA.

1992 • 21 citations

Response patterns of purified myeloma cells to hematopoietic growth factors

1989 • 19 citations

Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia

1989 • 16 citations

Differential expression and ligand-induced modulation of the human interleukin-6 receptor on interleukin-6-responsive cells.

1994 • 16 citations

Identification of immature and mature myeloma cells in the bone marrow of human myelomas

1993 • 15 citations

Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells

1993 • 8 citations

The IL-6 gene but not the IL-6 receptor gene is occasionally rearranged in patients with multiple myeloma.

1990 • 8 citations

Phenotypic analysis of human myeloma cell lines

1989 • 7 citations