Cytochrome c oxidase as a proton-pumping peroxidase: reaction cycle and electrogenic mechanism.

The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å

1996 • 2,089 citations

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

1995 • 1,991 citations

Structures of Metal Sites of Oxidized Bovine Heart Cytochrome c Oxidase at 2.8 Å

1995 • 1,380 citations

Heme/Copper Terminal Oxidases

1996 • 1,139 citations

Oxygen activation and the conservation of energy in cell respiration

1992 • 1,121 citations

Proton pump coupled to cytochrome c oxidase in mitochondria

1977 • 720 citations

The stereochemistry of peroxidase catalysis.

1980 • 683 citations

Chemiosmotic coupling in oxidative and photosynthetic phosphorylation

2011 • 541 citations

Cytochrome oxidase : a synthesis

1981 • 334 citations

The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved electrogenic intraprotein proton transfer

1997 • 315 citations

Identification of the electron transfers in cytochrome oxidase that are coupled to proton-pumping

1989 • 272 citations

Crystal structure of recombinant pea cytosolic ascorbate peroxidase

1995 • 244 citations

Role of Arginine 38 in Horseradish Peroxidase

1996 • 191 citations

Histidine 52 is a critical residue for rapid formation of cytochrome c peroxidase compound I

1993 • 176 citations

Involvement of intramitochondrial protons in redox reactions of cytochrome a

1978 • 158 citations

Proton uptake by cytochrome c oxidase on reduction and on ligand binding

1994 • 150 citations

The dioxygen cycle. Spectral, kinetic, and thermodynamic characteristics of ferryl and peroxy intermediates observed by reversal of the cytochrome oxidase reaction.

1992 • 134 citations

The histidine cycle: A new model for proton translocation in the respiratory heme-copper oxidases

1994 • 132 citations

Energy-dependent reversal of the cytochrome oxidase reaction.

1981 • 131 citations

Elementary steps in the formation of horseradish peroxidase compound I: direct observation of compound 0, a new intermediate with a hyperporphyrin spectrum

1989 • 129 citations

Effect of membrane potential on equilibrium poise between cytochromea and cytochromec in rat liver mitochondria

1970 • 126 citations

Effect of arginine-48 replacement on the reaction between cytochrome c peroxidase and hydrogen peroxide

1993 • 124 citations

Glutamic acid 286 in subunit I of cytochrome bo ₃ is involved in proton translocation

1997 • 116 citations

Bound water in the proton translocation mechanism of the haem‐copper oxidases

1997 • 115 citations

Laue diffraction study on the structure of cytochrome c peroxidase compound I

1994 • 112 citations

Selective resonance Raman observation of the “607 nm” form generated in the reaction of oxidized cytochrome c oxidase with hydrogen peroxide.

1994 • 111 citations

Control of electron delivery to the oxygen reduction site of cytochrome c oxidase: A role for protons

1995 • 107 citations

The Interaction of Cytochrome Oxidase with Hydrogen Peroxide: The Relationship of Compounds P and F

1995 • 100 citations

Flash‐induced membrane potential generation by cytochrome c oxidase

1993 • 99 citations

Proton transfer during the reaction between fully reduced cytochrome c oxidase and dioxygen: pH and deuterium isotope effects

1992 • 92 citations

Time-Resolved Resonance Raman Evidence for Tight Coupling between Electron Transfer and Proton Pumping of Cytochrome c Oxidase upon the Change from the Fe^V Oxidation Level to the Fe^IV Oxidation Level

1996 • 87 citations

Mechanism of cytochrome c oxidase-catalyzed dioxygen reduction at low temperatures. Evidence for two intermediates at the three-electron level and entropic promotion of the bond-breaking step

1985 • 86 citations

Structure of CuB in the Binuclear Heme-Copper Center of the Cytochrome aa3-Type Quinol Oxidase from Bacillus subtilis: An ENDOR and EXAFS Study

1995 • 83 citations

Polar Residues in Helix VIII of Subunit I of Cytochrome c Oxidase Influence the Activity and the Structure of the Active Site

1996 • 82 citations

Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy

1996 • 80 citations

‘As prepared’ forms of fully oxidised haem/Cu terminal oxidases

1996 • 78 citations

Translocation of electrical charge during a single turnover of cytochrome-c oxidase

1997 • 75 citations

Observation and Assignment of Peroxy and Ferryl Intermediates in the Reduction of Dioxygen to Water by Cytochrome c Oxidase

1996 • 75 citations

Cytochrome c oxidase binding of hydrogen peroxide

1982 • 74 citations

Resonance Raman/Absorption Characterization of the Oxo Intermediates of Cytochrome c Oxidase Generated in Its Reaction with Hydrogen Peroxide: pH and H₂O₂ Concentration Dependence

1996 • 69 citations

The effect of pH on redox titrations of haem a in cyanide-liganded cytochrome-c oxidase: experimental and modelling studies

1990 • 68 citations

2.2 Å structure of oxy-peroxidase as a model for the transient enzyme: peroxide complex

1994 • 67 citations

Uptake and release of protons during the reaction between cytochrome c oxidase and molecular oxygen: a flow-flash investigation

1991 • 67 citations

Identification of Putative Peroxide Intermediates of Peroxidases by Electronic Structure and Spectra Calculations

1996 • 66 citations

Mechanism of Cytochrome c Oxidase-Catalyzed Reduction of Dioxygen to Water: Evidence for Peroxy and Ferryl Intermediates at Room Temperature

1997 • 66 citations

H₂O₂‐Induced Conversion of Cytochrome c Oxidase Peroxy Complex to Oxoferryl State

1988 • 64 citations

Microcirculating System for Simultaneous Determination of Raman and Absorption Spectra of Enzymatic Reaction Intermediates and Its Application to the Reaction of Cytochrome c Oxidase with Hydrogen Peroxide

1996 • 63 citations

High-valent intermediates in the reaction of Nα-acetyl microperoxidase-8 with hydrogen peroxide: Models for compounds 0,I and II of horseradish peroxidase

1991 • 62 citations

Intermediates in the Reaction of Reduced Cytochrome Oxidase with Dioxygena

1988 • 57 citations

The location of Cu_A in mammalian cytochrome c oxidase

1988 • 52 citations

The cytochrome c peroxidase activity of cytochrome oxidase.

1982 • 51 citations

Redox-linked protolytic reactions in soluble cytochrome-c oxidase from beef-heart mitochondria: redox Bohr effects

1997 • 49 citations

Cytochrome oxidase‐catalyzed superoxide generation from hydrogen peroxide

1992 • 48 citations

Investigation of the Proton-Assisted Pathway to Formation of the Catalytically Active, Ferryl Species of P450s by Molecular Dynamics Studies of P450eryF

1996 • 46 citations

Rapid kinetics of membrane potential generation by cytochrome c oxidase with the photoactive Ru(II)‐tris‐bipyridyl derivative of cytochrome c as electron donor

1995 • 45 citations

Oxygen Activation by Cytochrome P450BM-3: Effects of Mutating an Active Site Acidic Residue

1997 • 45 citations

Effect of pH on the spectrum of cytochrome c oxidase hydrogen peroxide complex

1989 • 41 citations

Studies on Cytochrome a

1963 • 38 citations

Possible Protonmotive Osmochemistry in Cytochrome Oxidase

1988 • 37 citations

Redox transitions between oxygen intermediates in cytochrome-c oxidase.

1996 • 35 citations

pH changes associated with cytochrome c oxidase reaction with H₂O₂ Protonation state of the peroxy and oxoferryl intermediates

1992 • 33 citations

Superoxide dismutase activity of cytochrome oxidase

1978 • 31 citations

Evidence for two H₂O₂‐binding sites in ferric cytochrome c oxidase Indication to the O‐cycle?

1987 • 30 citations

Electrogenic proton exchange between cytochrome a₃ active center and M‐aqueous phase

1986 • 27 citations

Rapid proton release during flash-induced oxidation of cytochromecoxidase

1990 • 26 citations

A Heme-containing Ascorbate Oxidase from Pleurotus ostreatus

1996 • 24 citations

Proton pumping by cytochrome c oxidase is coupled to peroxidase half of its catalytic cycle

1997 • 23 citations

Kinetic investigations of the reactions of cytochrome c oxidase with hydrogen peroxide

1986 • 22 citations

Oxygen Reaction and Proton Uptake in Helix VIII Mutants of Cytochrome bo3

1995 • 22 citations

The oxidation of cytochrome c oxidase by hydrogen peroxide

1985 • 21 citations

Cytochrome c Peroxidase Activity of Bovine Heart Cytochrome Oxidase Incorporated in Liposomes and Generation of Membrane Potential1

1986 • 21 citations

Proton and electrical charge translocation by cytochrome-c oxidase

1997 • 19 citations

Spectral Intermediate in the Reaction of Ferrous Cytochrome P450cam with Superoxide Anion

1994 • 18 citations

Proton translocation by cytochrome oxidase vesicles catalyzing the peroxidatic oxidation of ferrocytochrome c.

1986 • 15 citations

Hydrogen peroxide is the end product of oxygen reduction by the terminal oxidase in the marine bacterium Pseudomonas nautica 617

1989 • 14 citations

[Role of protons in the operational mechanism of the 3d conjugation point of the respiratory chain of mitochondria: cytochrome oxidase as an electron-proton generator of the membrane potential].

1977 • 10 citations

Rate enhancement of the internal electron transfer in cytochrome c oxidase by the formation of a peroxide complex; its implication on the reaction mechanism of cytochrome c oxidase

1988 • 10 citations

Enhanced superoxide dismutase activity of pulsed cytochorme oxidase

1986 • 9 citations

Purification and characterization of the oxidase from the marine bacterium Pseudomonas nautica 617

1991 • 8 citations

The redox midpoint potential of haem a in cytochrome-c oxidase is sensitive to extramitochondrial pH

1989 • 6 citations

Deleted Work

1955 • 0 citations