Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: Implications for oxygen sensing and hypoxic signaling in eukaryotes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

2000 • 4,803 citations

Getting started with yeast

2002 • 3,496 citations

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1998 • 1,864 citations

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2000 • 1,860 citations

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2005 • 1,425 citations

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2004 • 1,414 citations

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2001 • 1,366 citations

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2003 • 885 citations

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2005 • 717 citations

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2003 • 683 citations

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2005 • 597 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

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2002 • 535 citations

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2005 • 423 citations

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2005 • 408 citations

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2003 • 390 citations

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1999 • 339 citations

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1999 • 295 citations

Genome-Wide Transcriptional Analysis of Aerobic and Anaerobic Chemostat Cultures of Saccharomyces cerevisiae

1999 • 257 citations

Reactions of nitric oxide with cytochrome c oxidase

1980 • 232 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

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1998 • 228 citations

Isolation and Subfractionation of Mitochondria from Animal Cells and Tissue Culture Lines

2007 • 226 citations

The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia

2000 • 208 citations

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

2001 • 197 citations

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2000 • 192 citations

Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes

1999 • 174 citations

Nuclear functions required for cytochrome c oxidase biogenesis in Saccharomyces cerevisiae. Characterization of mutants in 34 complementation groups.

1986 • 173 citations

Mitochondrial electron transport as a source for nitric oxide in the unicellular green alga Chlorella sorokiniana

2004 • 167 citations

Nitric Oxide and Cytochrome c Oxidase: Mechanisms of Inhibition and NO Degradation

2000 • 161 citations

Mitochondrial nitric oxide synthase

2003 • 153 citations

Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway

2001 • 143 citations

Exposure of Yeast Cells to Anoxia Induces Transient Oxidative Stress

2002 • 140 citations

Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist?

2005 • 123 citations

Mitochondria recycle nitrite back to the bioregulator nitric monoxide.

2000 • 116 citations

Intracellular pH Distribution in Saccharomyces cerevisiae Cell Populations, Analyzed by Flow Cytometry

2005 • 100 citations

The steady-state kinetics of cytochrome c oxidation by cytochrome oxidase

1990 • 98 citations

Chapter 1 Isolation and subfractionation of mitochondria from animal cells and tissue culture lines

2001 • 97 citations

Function and Expression of Flavohemoglobin in Saccharomyces cerevisiae

1996 • 86 citations

Yeast Flavohemoglobin, a Nitric Oxide Oxidoreductase, Is Located in Both the Cytosol and the Mitochondrial Matrix

2004 • 85 citations

Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia

2003 • 82 citations

Dynamical Remodeling of the Transcriptome during Short-Term Anaerobiosis in Saccharomyces cerevisiae: Differential Response and Role of Msn2 and/or Msn4 and Other Factors in Galactose and Glucose Media

2005 • 81 citations

Oxygen Sensing

2003 • 81 citations

Mitochondrial gene expression in saccharomyces cerevisiae. I. Optimal conditions for protein synthesis in isolated mitochondria.

1984 • 75 citations

Models for oxygen sensing in yeast: implications for oxygen-regulated gene expression in higher eucaryotes

1999 • 72 citations

Hypoxia-inducible Factor 1α (HIF-1α) Is a Non-heme Iron Protein

1998 • 71 citations

Nitrosyl-Heme Complexes Are Formed in the Ischemic Heart

2004 • 68 citations

Heart mitochondrial nitric oxide synthase. Effects of hypoxia and aging

2004 • 63 citations

Mechanisms of nitric oxide generation from nitroglycerin and endogenous sources during hypoxia in vivo

2002 • 57 citations

Effects of Anoxia and the Mitochondrion on Expression of Aerobic Nuclear COX Genes in Yeast

2001 • 55 citations

[8] Cytochrome-c oxidase from Saccharomyces cerevisiae

1995 • 52 citations

Effects of nitric oxide donors on vascular endothelial growth factor gene induction

2002 • 51 citations

Hypoxic induction of hypoxia-inducible factor-1α and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells

2002 • 49 citations

A new method to measure nitrate/nitrite with a NO-sensitive electrode

2001 • 46 citations

Dynamicin vivo31P nuclear magnetic resonance study ofSaccharomyces cerevisiae in glucose-limited chemostat culture during the aerobic-anaerobic shift

2000 • 38 citations

Phosphorus-31 NMR saturation-transfer and carbon-13 NMR kinetic studies of glycolytic regulation during anaerobic and aerobic glycolysis

1987 • 29 citations

Nitric Oxide Synthase-Independent Generation of Nitric Oxide in Rat Skeletal Muscle Ischemia-Reperfusion Injury

1999 • 26 citations

Effects of a transition from normoxia to anoxia on yeast cytochrome c oxidase and the mitochondrial respiratory chain

2005 • 24 citations

The effect of nitrite on cytochrome oxidase

1985 • 23 citations

Physiologic pH changes modulate calcium ion dependence of brain nitric oxide synthase in Carassius auratus

2002 • 13 citations

A Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast

2003 • 8 citations

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2004 • 8 citations

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1999 • 6 citations