Identification and Characterization of a Gene That Is Coamplified with Dihydrofolate Reductase in a Methotrexate-Resistant CHO Cell Line

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Genomic sequencing.

1984 • 8,343 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Methylmercury as a reversible denaturing agent for agarose gel electrophoresis

1976 • 1,323 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

Advanced Bacterial Genetics: A Manual for Genetic Engineering

1980 • 856 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Gene amplification in cultured animal cells

1984 • 639 citations

GENE AMPLIFICATION

1984 • 580 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Transcriptional elements as components of eukaryotic origins of DNA replication

1988 • 341 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends

1986 • 187 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

The temporal order of replication of murine immunoglobulin heavy chain constant region sequences corresponds to their linear order in the genome

1982 • 93 citations

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

1983 • 87 citations

Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA

1980 • 79 citations

Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.

1986 • 58 citations

The control of globin and other eukaryotic genes

1982 • 49 citations

Expression of several amplified genes in an adenylate-deaminase overproducing variant of Chinese hamster fibroblasts.

1984 • 40 citations

The gene for ornithine decarboxylase is co-amplified in hydroxyurea-resistant hamster cells.

1987 • 32 citations

Polyadenylation of Chinese hamster dihydrofolate reductase genomic genes and minigenes after gene transfer

1987 • 24 citations

Detection of a countertranscript in promyelocytic leukemia cells HL60 during early differentiation by TPA

1985 • 6 citations