Growth Hormone-induced Differential Desensitization of STAT5, ERK, and Akt Phosphorylation

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Sexual Dimorphism in the Control of Growth Hormone Secretion*

1985 • 749 citations

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

1976 • 743 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms

1999 • 364 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1997 • 286 citations

Mechanism of signaling by growth hormone receptor

1996 • 264 citations

Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.

1995 • 242 citations

Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver

1996 • 225 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 208 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.

1994 • 179 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent

2000 • 173 citations

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1995 • 168 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 129 citations

Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling

1996 • 124 citations

Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.

1994 • 123 citations

Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone

2000 • 123 citations

Signaling Molecules Involved in Coupling Growth Hormone Receptor to Mitogen-Activated Protein Kinase Activation*

1997 • 120 citations

Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.

1995 • 106 citations

Insulin Inhibits Growth Hormone Signaling via the Growth Hormone Receptor/JAK2/STAT5B Pathway

1999 • 83 citations

Termination of Growth Hormone Pulse-Induced STAT5b Signaling

1999 • 76 citations

Down-Regulation of Liver JAK2-STAT5b Signaling by the Female Plasma Pattern of Continuous Growth Hormone Stimulation

1999 • 75 citations

Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells.

1994 • 75 citations

The CIS Family: Negative Regulators of JAK–STAT Signaling

1998 • 72 citations

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

1996 • 69 citations

Roles of pulsatility and continuity of growth hormone (GH) administration in the regulation of hepatic GH-receptors, and circulating GH-binding protein and insulin-like growth factor-I.

1992 • 66 citations

Growth Hormone-Dependent Tyrosine Phosphorylation of a GH Receptor-Associated High Molecular WEIGHT Protein Immunologically Related to JAK2

1998 • 62 citations

PLASMA LEVELS OF GROWTH HORMONE IN FEMALE RATS OF DIFFERENT AGES

1978 • 59 citations

Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

1989 • 58 citations

Studies with a Growth Hormone Antagonist and Dual-fluorescent Confocal Microscopy Demonstrate that the Full-length Human Growth Hormone Receptor, but Not the Truncated Isoform, Is Very Rapidly Internalized Independent of Jak2-Stat5 Signaling

1999 • 57 citations

Insulin Receptor Substrate-1-Mediated Enhancement of Growth Hormone-Induced Mitogen-Activated Protein Kinase Activation*

2000 • 52 citations

Insulin Receptor Substrate-1 Enhances Growth Hormone-Induced Proliferation*

1999 • 51 citations

The CIS/JAB family: novel negative regulators of JAK signaling pathways

1998 • 51 citations

Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor.

1994 • 50 citations

Insulin and Dexamethasone Regulation of a Rat Hepatoma Messenger Ribonucleic Acid: Insulin Has a Transcriptional and a Posttranscriptional Effect*

1989 • 50 citations

Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells

1997 • 41 citations

The Antilipolytic, Insulin-Like Effect of Growth Hormone Is Caused by a Net Decrease of Hormone-Sensitive Lipase Phosphorylation*

1984 • 39 citations

A Membrane-Fixed, Truncated Isoform of the Human Growth Hormone Receptor1

1997 • 36 citations

Cis desensitizes GH induced Stat5 signaling in rat liver cells

1999 • 36 citations

Growth Hormone Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Cell Type Specific*

1998 • 36 citations

LY 294002, an Inhibitor of Phosphatidylinositol 3-Kinase, Inhibits GH-Mediated Expression of the IGF-I Gene in Rat Hepatocytes

2001 • 32 citations

Refractoriness to growth hormone is associated with increased intracellular calcium in rat adipocytes.

1991 • 31 citations

Comparison of Several Insulin-Like Effects of Growth Hormone

1979 • 30 citations

Different Growth Hormone-Receptor Interactions Mediate Insulin-Like and Lipolytic Responses of Rat Adipose Tissue*

1989 • 22 citations