Termination of Growth Hormone Pulse-Induced STAT5b Signaling

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Sexual Dimorphism in the Control of Growth Hormone Secretion*

1985 • 749 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling

1998 • 315 citations

Molecular Mechanism of Growth Hormone Action

1996 • 309 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450.

1991 • 255 citations

Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.

1995 • 242 citations

Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver

1996 • 225 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

1997 • 205 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

Termination of endothelin signaling: Role of nitric oxide

1994 • 193 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Involvement of the Src Homology 2-containing Tyrosine Phosphatase SHP-2 in Growth Hormone Signaling

1998 • 163 citations

Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion.

1992 • 140 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation

1997 • 129 citations

Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.

1996 • 126 citations

Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.

1994 • 123 citations

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

1995 • 118 citations

Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes.

1992 • 115 citations

Identification of Tyrosine Residues in the Intracellular Domain of the Growth Hormone Receptor Required for Transcriptional Signaling and Stat5 Activation

1996 • 114 citations

In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.

1995 • 106 citations

Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5.

1997 • 101 citations

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

1997 • 100 citations

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.

1996 • 90 citations

Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription.

1995 • 85 citations

Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium.

1987 • 82 citations

Hormonal Regulation of Liver Cytochrome P450 Enzymes

2015 • 80 citations

Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins

1997 • 80 citations

Down-Regulation of Liver JAK2-STAT5b Signaling by the Female Plasma Pattern of Continuous Growth Hormone Stimulation

1999 • 75 citations

Growth Hormone-induced Signal Transduction Depends on an Intact Ubiquitin System

1997 • 69 citations

Binding of STAT5a and STAT5b to a Single Element Resembling a γ-Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells

1998 • 67 citations

The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction

1997 • 67 citations

Regulation of Growth Factor-Induced Signaling by Protein-Tyrosine-Phosphatases

1997 • 48 citations

Growth Hormone-dependent Phosphorylation of Tyrosine 333 and/or 338 of the Growth Hormone Receptor

1995 • 45 citations

Growth hormone receptor signalling

1996 • 42 citations

STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase

1998 • 40 citations

Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation.

1990 • 36 citations

Distinct Cytoplasmic Domains of the Growth Hormone Receptor Are Required for Glucocorticoid- and Phorbol Ester-induced Decreases in Growth Hormone (GH) Binding

1996 • 30 citations

Regulation of the growth hormone (GH) receptor and GH-binding protein by GH pulsatility

1993 • 25 citations

Growth hormone induces detergent insolubility of GH receptors in IM-9 cells

1997 • 23 citations

Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone

1995 • 22 citations