Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The Metabolic Basis of Inherited Diseases

1972 • 1,762 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family

1988 • 564 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Insulin-Stimulated Hydrolysis of a Novel Glycolipid Generates Modulators of cAMP Phosphodiesterase

1986 • 383 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Sphingosine inhibits calmodulin-dependent enzymes.

1988 • 215 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

Chemistry and Metabolism of Sphingolipids. 3-Oxo Derivatives of N-Acetylsphingosine and N-Acetyldihydrosphingosine

1966 • 185 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan.

1987 • 166 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.

1985 • 155 citations

The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+

1985 • 146 citations

Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover.

1989 • 141 citations

Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes.

1984 • 136 citations

Phorbol Ester Provokes Insulin-Like Effects on Glucose Transport, Amino Acid Uptake, and Pyruvate Dehydrogenase Activity in BC3H-1 Cultured Myocytes*

1985 • 130 citations

The phorbol ester, TPA inhibits glucagon‐stimulated adenylate cyclase activity

1984 • 128 citations

GROWTH HORMONE AND THE METABOLISM OF CARBOHYDRATE AND LIPID IN ADIPOSE TISSUE^*

1968 • 124 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue.

1982 • 110 citations

Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytes

1988 • 109 citations

Aminoacridines, potent inhibitors of protein kinase C.

1988 • 96 citations

Membrane effects of tumor promoters: Stimulation of sugar uptake in mammalian cell cultures

1979 • 95 citations

Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.

1985 • 92 citations

Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture

1987 • 83 citations

The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.

1986 • 80 citations

Insulin Stimulation of Glucose Metabolism in Rat Adipocytes: Possible Implication of Protein Kinase C*

1986 • 77 citations

Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding

1985 • 77 citations

Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes

1985 • 75 citations

Insulin-stimulated phosphoinositide metabolism in isolated fat cells.

1985 • 71 citations

Insulin increases membrane protein kinase C activity in rat diaphragm

1987 • 65 citations

Phorbol esters, but not insulin, promote depletion of cytosolic protein kinase C in rat adipocytes

1986 • 62 citations

The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue

1966 • 61 citations

Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.

1985 • 60 citations

Insulin provokes a transient activation of phospholipase C in the rat epididymal fat pad.

1986 • 58 citations

Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes.

1988 • 58 citations

Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

1986 • 50 citations

Rapid effects of phorbol esters on isolated rat adipocytes. Relationship to the action of protein kinase C

1985 • 50 citations

Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytes

1987 • 50 citations

Insulin and phorbol ester stimulate phosphorylation of a 40-kDa protein in adipocyte plasma membranes.

1985 • 46 citations

DECREASED INSULIN RESPONSIVENESS IN FAT CELLS RENDERED PROTEIN KINASE C-DEFICIENT BY A TREATMENT WITH A PHORBOL ESTER.

1987 • 44 citations

Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes.

1987 • 42 citations

Vasopressin rapidly stimulates protein kinase C in quiescent Swiss 3T3 cells

1986 • 39 citations

Purification of the 22000- and 20000-mol.wt. forms of human somatotropin and characterization of their binding to liver and mammary binding sites

1983 • 29 citations

Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway.

1988 • 28 citations

Regulation of hexose transport in BALB/c 3T3 preadipose cells: Effects of glucose concentration and 12‐O‐tetradeconoylphorbol‐13‐acetate

1982 • 26 citations

Acridine orange, an inhibitor of protein kinase C, abolishes insulin and growth hormone stimulation of lipogenesis in rat adipocytes

1989 • 24 citations

Insulin treatment acutely increases the concentration of phosphatidylserine in rat adipose tissue

1983 • 24 citations

Protein Kinases in Cellular Signal Transduction: Tyrosine Kinase Growth Factor Receptors and Protein Kinase C

1986 • 24 citations

Further observations on the increases in inositide phospholipids after stimulation by ACTH, cAMP and insulin, and on discrepancies in phosphatidylinositol mass and 32PO4-labeling during inhibition of hormonal effects by cycloheximide

1983 • 19 citations

Growth hormone and insulin-like growth factors I and II produce distinct alterations in glucose metabolism in 3T3-F442A adipocytes.

1985 • 19 citations