Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Cytokines in cancer pathogenesis and cancer therapy

2004 • 1,465 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

Complete molecular remissions induced by patient-specific vaccination plus granulocyte–monocyte colony-stimulating factor against lymphoma

1999 • 604 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention

2005 • 474 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial

2004 • 441 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

What messenger RNA capping tells us about eukaryotic evolution

2002 • 351 citations

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

2002 • 289 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Differentiating between Memory and Effector Cd8 T Cells by Altered Expression of Cell Surface O-Glycans

2000 • 207 citations

The role of programming in memory T-cell development

2004 • 195 citations

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

1998 • 188 citations

GM-CSF-secreting melanoma vaccines

2003 • 171 citations

Cutting Edge: In Contrast to Effector T Cells, CD4+CD25+FoxP3+ Regulatory T Cells Are Highly Susceptible to CD95 Ligand- but Not to TCR-Mediated Cell Death

2005 • 171 citations

TNF-α and IFN-γ render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL

1998 • 144 citations

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.

1999 • 141 citations

In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity.

2000 • 138 citations

Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease.

2002 • 118 citations

Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells

2002 • 112 citations

How T lymphocytes switch between life and death

2006 • 108 citations

Preparation of Cells and Reagents for Flow Cytometry

2001 • 108 citations

Reciprocal Changes in Tumor Antigenicity and Antigen-specific T Cell Function during Tumor Progression

2004 • 102 citations

Double-blind trial of a polyvalent, shed-antigen, melanoma vaccine.

2001 • 100 citations

Regulation of T cell Apoptosis during the Immune Response

2002 • 100 citations

Duration of Infection and Antigen Display Have Minimal Influence on the Kinetics of the CD4+ T Cell Response to Listeria monocytogenes Infection

2004 • 94 citations

Quiescent phenotype of tumor-specific CD8+ T cells following immunization

2004 • 86 citations

Interleukin-12 Inhibits Graft-Versus-Host Disease Through an Fas-Mediated Mechanism Associated With Alterations in Donor T-Cell Activation and Expansion

1998 • 76 citations

Intratumoral immunotherapy: using the tumour against itself

2004 • 71 citations

Human CD4+ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN-γ, and Eradicate Tumor Cells

2005 • 66 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

Active-specific immunization against melanoma: Is the problem at the receiving end?

2003 • 53 citations

Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing

2005 • 51 citations

Recent developments in therapeutic cancer vaccines

2005 • 50 citations

Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression.

2001 • 45 citations

Dynamic regulation of FoxP3 expression controls the balance between CD4⁺ T cell activation and cell death

2005 • 41 citations

Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-γ and is independent of perforin and granzymes

2002 • 29 citations

MONITORING IMMUNE RESPONSES IN CANCER PATIENTS RECEIVING TUMOR VACCINES

2003 • 29 citations

Turning On/Off Tumor-Specific CTL Response during Progressive Tumor Growth

2005 • 24 citations

IL-12 PLAYS A SIGNIFICANT ROLE IN THE APOPTOSIS OF HUMAN T CELLS IN THE ABSENCE OF ANTIGENIC STIMULATION

2002 • 20 citations

The influence of CD95L expression on tumor rejection in mice

2003 • 15 citations