Culturing hepatocytes and other differentiated cells

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

The Cell in Development and Heredity

1925 • 1,750 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER

1967 • 1,482 citations

Role of collagenous matrices in the adhesion and growth of cells.

1981 • 1,375 citations

Fibronectins: multifunctional modular glycoproteins.

1982 • 1,334 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Junctional intercellular communication: the cell-to-cell membrane channel.

1981 • 1,268 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

CELL SURFACE INTERACTIONS WITH EXTRACELLULAR MATERIALS

1983 • 1,147 citations

Osteonectin, a bone-specific protein linking mineral to collagen

1981 • 1,131 citations

Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture

1983 • 1,088 citations

FRACTURE FACES OF ZONULAE OCCLUDENTES FROM "TIGHT" AND "LEAKY" EPITHELIA

1973 • 1,086 citations

Methods for growth of cultured cells in serum-free medium

1980 • 1,013 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes

1981 • 889 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM

1965 • 833 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

Teratocarcinomas and Mammalian Embryogenesis

1980 • 767 citations

Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.

1975 • 710 citations

Structure of the junction between communicating cells

1980 • 697 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

A RAPID METHOD FOR VIABLE CELL TITRATION AND CLONE PRODUCTION WITH HELA CELLS IN TISSUE CULTURE: THE USE OF X-IRRADIATED CELLS TO SUPPLY CONDITIONING FACTORS

1955 • 637 citations

Intracellular pH: Its Measurement, Regulation, and Utilization in Cellular Functions.

1982 • 544 citations

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

1983 • 511 citations

Cell Biology and Biochemistry of Endochondral Bone Development

1981 • 487 citations

Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts.

1976 • 473 citations

Extracellular matrix.

1981 • 471 citations

Biochemical characteristics and biological significance of the genetically-distinct collagens

1976 • 468 citations

Molecular Basis of Proteinuria of Glomerular Origin

1978 • 444 citations

Clonal growth of normal human epidermal keratinocytes in a defined medium

1982 • 442 citations

Hormone-Induced Morphogenesis and Growth: Role of Mesenchymal–Epithelial Interactions

1983 • 441 citations

Glycosaminoglycans in Morphogenesis

1981 • 436 citations

The influence of collagen on the development of muscle clones.

1966 • 436 citations

Permissive effect of the extracellular matrix on cell proliferation in vitro.

1980 • 412 citations

Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes.

1980 • 395 citations

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

1984 • 376 citations

Experimental modulation of occluding junctions in a cultured transporting epithelium.

1980 • 375 citations

Teratocarcinomas as a model system for the study of embryogenesis and neoplasia

1975 • 361 citations

PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE*

1980 • 347 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Gap junction structures. I. Correlated electron microscopy and x-ray diffraction.

1977 • 341 citations

A simple, versatile, nondisruptive method for the isolation of morphologically and chemically pure basement membranes from several tissues

1975 • 337 citations

[5] Media and growth requirements

1979 • 331 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells.

1978 • 324 citations

Changes in Liver-Specific Compared to Common Gene Transcription During Primary Culture of Mouse Hepatocytes

1983 • 316 citations

Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata.

1984 • 314 citations

DEPENDENCE OF SALIVARY EPITHELIAL MORPHOLOGY AND BRANCHING MORPHOGENESIS UPON ACID MUCOPOLYSACCHARIDE-PROTEIN (PROTEOGLYCAN) AT THE EPITHELIAL SURFACE

1972 • 304 citations

Primary embryonic induction

1962 • 289 citations

HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGIN

1962 • 285 citations

Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin.

1983 • 281 citations

Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology.

1977 • 273 citations

Evidence for Paracrine Interaction between Gonadotrophs and Lactotrophs in Pituitary Cell Aggregates*

1983 • 268 citations

Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes

1980 • 266 citations

Extracellular matrix promotes mammary epithelial growth and differentiation in vitro.

1982 • 262 citations

[45] Proteoglycans: Isolation and Characterization

1982 • 261 citations

Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes.

1979 • 251 citations

Cell-surface heparan sulfate: an intercalated membrane proteoglycan.

1981 • 246 citations

The terminal web. A reevaluation of its structure and function.

1979 • 243 citations

Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice

1969 • 243 citations

[1] Collagen: An overview

1982 • 241 citations

Epidermal cells adhere preferentially to type IV (basement membrane) collagen.

1979 • 240 citations

Structure of the pericellular matrix: Association of heparan and chondroitin sulfates with fibronectin-procollagen fibers

1982 • 230 citations

The effect of spatial arrangement on cell determination during mouse development

1972 • 230 citations

Über die Determination der ersten Organanlagen des Amphibienembryo I–VI

1918 • 228 citations

Clonal growth of human keratinocytes with small amounts of dialyzed serum

1980 • 224 citations

Cell-surface heparan sulfate. Isolation and characterization of a proteoglycan from rat liver membranes.

1979 • 223 citations

Roles of Extracellular Matrix in Neural Development

1983 • 223 citations

Modulation of functional activities in cultured rat hepatocytes

1983 • 219 citations

Epithelio‐mesenchymal specificity in the morphogenesis of mouse sub‐mandibular rudiments in vitro

1953 • 216 citations

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

1981 • 208 citations

Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes.

1983 • 206 citations

Loss of anionic sites from the glomerular basement membrane in aminonucleoside nephrosis.

1978 • 199 citations

Evidence that contact with connective tissue matrix is required for normal interaction between Schwann cells and nerve fibers.

1978 • 190 citations

The turnover of basal lamina glycosaminoglycan correlates with epithelial morphogenesis

1982 • 187 citations

Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis.

1984 • 184 citations

Foundations of experimental embryology

1964 • 183 citations

Long-Term Co-Cultures of Adult Human Hepatocytes with Rat Liver Epithelial Cells: Modulation of Albumin Secretion and Accumulation of Extracellular Material

1984 • 183 citations

Ectoderm — mesoderm relationship in the development of the chick embryo limb bud

1955 • 176 citations

[29] Collagen as a substrate for cell growth and differentiation

1982 • 165 citations

Chapter 34 Differentiation and Proliferation of Hemopoietic Cells in Culture

1976 • 164 citations

Posttranscriptional modulation of gene expression in cultured rat hepatocytes.

1984 • 161 citations

Structure of rapidly frozen gap junctions.

1980 • 160 citations

Control Circuits for Determination and Transdetermination

1973 • 153 citations

Gap Junctional Communication

1981 • 152 citations

Industrial Noise Pollution and Hearing Impairment

1982 • 144 citations

Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells.

1982 • 141 citations

A study of communication specificity between cells in culture.

1977 • 137 citations

An Endocrine Approach to the Control of Epidermal Growth: Serum-Free Cultivation of Human Keratinocytes

1981 • 134 citations

Embryonic Development and Induction

1939 • 132 citations

The extracellular matrix and the control of proliferation of vascular endothelial and vascular smooth muscle cells

1980 • 129 citations

Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells

1981 • 128 citations

Homoeotic genes, compartments and cell determination in Drosophila

1977 • 127 citations

Primary cultures of hepatocytes on human fibroblasts

1979 • 119 citations

Retrodifferentiation and the Fetal Patterns of Gene Expression in Cancer

1979 • 117 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Pattern Formation in Biological Development

1978 • 117 citations

Growth of Cultured Cells Using Collagen as Substrate

1983 • 116 citations

Type I collagen reduces the degradation of basal lamina proteoglycan by mammary epithelial cells.

1981 • 114 citations

Biological Properties of the Nuclear Matrix: Steroid Hormone Binding

1982 • 113 citations

Compartments in Animal Development

1979 • 110 citations

Transdetermination in Cells

1968 • 108 citations

Cultivation of the liver forms of Plasmodium vivax in human hepatocytes

1984 • 108 citations

Tissue interactions between epithelium and mesenchyme of urogenital and integumental origin

1972 • 105 citations

Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line.

1984 • 96 citations

Structural integrity of hepatocyte tight junctions.

1983 • 95 citations

Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes

1976 • 95 citations

Growth Factors and Regulation of Cell Growth

1982 • 92 citations

The isolation and partial characterization of chondronectin, an attachment factor for chondrocytes.

1982 • 90 citations

Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes.

1978 • 90 citations

Clonal Growth of Mouse Epidermal Cells in Medium with Reduced Calcium Concentration

1981 • 82 citations

[47] Laminin

1982 • 80 citations

Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata.

1983 • 79 citations

The role of inhibited cell-cell communication in teratogenesis

1982 • 76 citations

Cell Culture Studies Using Extracts of Extracellular Matrix to Study Growth and Differentiation in Mammalian Cells

1984 • 74 citations

LONG‐TERM CULTURES OF NORMAL RAT HEPATOCYTES ON LIVER BIOMATRIX

1980 • 72 citations

Collagens of Basement Membranes

1982 • 70 citations

Suppressor Activity of T Lymphocytes from Infants Assessed by Co-Culture with Unfractionated Adult Lymphocytes in the Pokeweed Mitogen System

1979 • 64 citations

Comparison of the growth of normal and neoplastic mouse mammary cells on plastic, on collagen gels and in collagen gels

1983 • 60 citations

Maintenance of adult rat hepatocytes on C3H/10T1/2 cells.

1979 • 60 citations

ON THE FUNCTIONS OF X-IRRADIATED “FEEDER” CELLS IN SUPPORTING GROWTH OF SINGLE MAMMALIAN CELLS

1956 • 57 citations

γ-Glutamyltranspeptidase induction mediated by glial foot process-to endothelium contact in co-culture

1981 • 57 citations

Comparative studies on adult donor lymphocytes infected by EB virus in vivo or in vitro: Origin of transformed cells arising in co‐cultures with foetal lymphocytes

1977 • 55 citations

Characterization of marrow stromal (fibroblastoid) cells and their association with erythropoiesis.

1980 • 54 citations

Interacting systems in development

1970 • 53 citations

Cellular interactions in animal development

1975 • 51 citations

Collagens of Basement Membranes.

1982 • 51 citations

Hydrocortisone modulates the production of extracellular material and albumin in long-term cocultures of adult rat hepatocytes with other liver epithelial cells

1982 • 50 citations

Chapter 6 Cell Surface and Early Stages of Mouse Embryogenesis

1979 • 46 citations

Interferon production in cocultures between mouse spleen cells and tumor cells. Possible role of mycoplasmas in interferon induction

1980 • 44 citations

Endothelial cell culture on fibrillar collagen: model to study platelet adhesion and liposome targeting to intercellular collagen matrix.

1981 • 44 citations

To grow mouse mammary epithelial cells in culture.

1984 • 43 citations

Neonatal retinal ganglion cell cultures of high purity: Effect of superior colliculus on their survival

1983 • 39 citations

The origin of pattern and feather germ tract specificity

1957 • 35 citations

Mitomycin C treated cells as feeders

1971 • 34 citations

Pineal gland cells in culture

1977 • 34 citations

Enhanced chemosensitivity of chick parasympathetic neurones in co‐culture with myotubes.

1982 • 33 citations

Laminin provides a better substrate than fibronectin for attachment, growth, and differentiation of 1003 embryonal carcinoma cells

1982 • 32 citations

Gap junction dynamics and intercellular communication.

1978 • 31 citations

Transporting Renal Epithelium: Culture in Hormonally Defined Serum-Free Medium

1980 • 29 citations

Modulation of lymphocyte mitogen responses by cocultured fibroblasts

1981 • 29 citations

Induction of neural differentiation by serum deprivation in cultures of the embryonal carcinoma cell line 1003*1

1982 • 29 citations

Transplantation of mouse mammary epithelial cells grown in primary collagen gel cultures.

1982 • 27 citations

Involvement of collagen formation in the hormonally induced functional differentiation of mouse mammary gland in organ culture.

1983 • 26 citations

Involvement of collagen in the aggregation of acetylcholine receptors on cultured muscle cells.

1982 • 25 citations

Endothelial cell-matrix interactions in hemostasis.

1982 • 23 citations

Growth factors and pattern formation

1981 • 22 citations

Regulation of local differentiation of cartilage and bone by extracellular matrix: a cascade type mechanism.

1982 • 22 citations

Influence of asbestos fibers on collagen and prostaglandin production in fibroblast and macrophage co-cultures.

1982 • 22 citations

Mammalian cell culture : the use of serum-free hormone-supplemented media

1984 • 22 citations

Glycosaminoglycans and Proteoglycans in Physiological and Pathological Processes of Body Systems

1983 • 21 citations

Hypomyelinated mutant mice. III. Increased myelination in mutant cerebellum co-cultured with normal optic nerve

1981 • 20 citations

The behavior of subcultivated stratified squamous epithelial cells on reconstituted extracellular matrices: initial interactions.

1982 • 20 citations

REGULATION OF GROWTH AND DIFFERENTIATION OF MAMMALIAN CELLS BY HORMONES AND EXTRACELLULAR MATRIX

1982 • 19 citations

Regulation of tadpole spinal nerve fiber growth by the regenerating limb blastema in tissue culture

1983 • 19 citations

Identification of rabbit and mouse β-glucuronidases in human fibroblasts following direct interaction with lymphocytes

1982 • 17 citations

GROWTH AND DIFFERENTIATION OF RAT MAMMARY EPITHELIUM ON MAMMARY GLAND EXTRACELLULAR MATRIX11This work was supported by grants BC-357 from the American Cancer Society and HD 16721 from the National Institutes of Health.

1982 • 16 citations

The effect of different collagen types used as substrata on myogenesis in tissue culture

1980 • 16 citations

Distribution of cell surface lets protein in co-cultures of normal and transformed cells

1977 • 16 citations

Correlation of the cell phenotype of cultured cell lines with their adhesion to components of the extracellular matrix

1983 • 13 citations

Role of cell--cell interaction in normal and abnormal erythropoiesis.

1980 • 11 citations

An Overview of Proteoglycans in Physiology and Pathology

2015 • 11 citations

Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

1982 • 11 citations

Mutagenesis and DNA binding of benzo(a)pyrene in cocultures of rat hepatocytes and human fibroblasts.

1982 • 10 citations

Interaction of human carcinoma cells with an epithelial layer and the underlying basement membrane. A new model.

1981 • 10 citations

Characterization of a type‐C virus produced by co‐cultures of human leukemic bone‐marrow and fetal canine thymus cells

1979 • 10 citations

Changes in intracellular enzymes of collagen biosynthesis during matrix-induced cartilage and bone development

1981 • 8 citations

Monocyte enhancement of mitogen-induced lymphocyte proliferation in a human co-culture system

1978 • 7 citations

In Vitro Cytotoxicity of Mouse Macrophages Activated by Coculture with Syngeneic Sarcoma Cells

1982 • 7 citations

Evolutionary Aspects of Cell Differentiation

1982 • 7 citations

Genetic control of cell-cell interactions.

1982 • 6 citations

Interaction of adult rat liver cells and C3H/10T1/2 mouse embryo fibroblasts in co-culture.

1979 • 5 citations

HUMAN MONOCYTES INDUCE A REVERSIBLE INHIBITION OF CELL CYCLE PROGRESSION IN THE LEUKEMIC CELL LINE K‐562 DURING CO‐CULTURE IN VITRO

1981 • 5 citations

Regulation of the proliferation of embryonic chick leptomeningeal cells in vitro by both contact inhibition and co‐culture with CNS neurons

1982 • 3 citations

A case of selective immunoglobulin G deficiency: Analysis of coculture with normal lymphocytes in vitro

1981 • 2 citations

[27] Biosynthetic matrices from cells in culture

1982 • 2 citations

Deleted Work

1955 • 0 citations