Cell Culture Studies Using Extracts of Extracellular Matrix to Study Growth and Differentiation in Mammalian Cells

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

1982 • 2,259 citations

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

Fibronectins—adhesive glycoproteins of cell surface and blood

1978 • 1,418 citations

Role of collagenous matrices in the adhesion and growth of cells.

1981 • 1,375 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes

1981 • 889 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM

1965 • 833 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 779 citations

Human Tumor Cells in Vitro

1975 • 753 citations

Cell surface proteins and malignant transformation

1976 • 713 citations

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

1980 • 672 citations

Proteinpolysaccharide Complex from Bovine Nasal Cartilage

1969 • 669 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

Capillary endothelial cell cultures: phenotypic modulation by matrix components.

1983 • 611 citations

A murine tumor producing a matrix of basement membrane.

1977 • 602 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Isolation of a collagen-dependent cell attachment factor

1974 • 578 citations

The structure and chemical characterization of elastic fibers as reveled by elastase and by electron microscopy

1952 • 525 citations

Microtrabecular lattice of the cytoplasmic ground substance. Artifact or reality.

1979 • 516 citations

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

1983 • 511 citations

Cell Biology and Biochemistry of Endochondral Bone Development

1981 • 487 citations

Extracellular matrix.

1981 • 471 citations

Biochemical characteristics and biological significance of the genetically-distinct collagens

1976 • 468 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Molecular Basis of Proteinuria of Glomerular Origin

1978 • 444 citations

The influence of collagen on the development of muscle clones.

1966 • 436 citations

Relationships between fibronectin (LETS protein) and actin

1978 • 428 citations

Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent.

1976 • 423 citations

Permissive effect of the extracellular matrix on cell proliferation in vitro.

1980 • 412 citations

Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts

1980 • 399 citations

Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes.

1980 • 395 citations

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

1984 • 376 citations

Inductive Epithelio-mesenchymal Interaction in Cultured Organ Rudiments of the Mouse

1953 • 367 citations

International Cell Biology 1980–1981

1981 • 363 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE*

1980 • 347 citations

Cytoplasmic Structure and Contractility in Amoeboid Cells

1979 • 343 citations

Nature of the Collagenous Protein in a Tumor Basement Membrane

1978 • 337 citations

A simple, versatile, nondisruptive method for the isolation of morphologically and chemically pure basement membranes from several tissues

1975 • 337 citations

Stimulation of corneal endothelial cell proliferation in vitro by fibroblast and epidermal growth factors

1977 • 335 citations

[5] Media and growth requirements

1979 • 331 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

Response of basal epithelial cell surface and Cytoskeleton to solubilized extracellular matrix molecules.

1981 • 329 citations

Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse

1969 • 327 citations

Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic

1980 • 312 citations

DEPENDENCE OF SALIVARY EPITHELIAL MORPHOLOGY AND BRANCHING MORPHOGENESIS UPON ACID MUCOPOLYSACCHARIDE-PROTEIN (PROTEOGLYCAN) AT THE EPITHELIAL SURFACE

1972 • 304 citations

The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins

1979 • 298 citations

Synthesis of cartilage matrix by mammalian chondrocytes in vitro. I. Isolation, culture characteristics, and morphology.

1982 • 288 citations

Basement membrane glycoprotein laminin binds to heparin

1980 • 286 citations

HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGIN

1962 • 285 citations

Mammalian lung development: Interactions in formation and morphogenesis of tracheal buds

1970 • 284 citations

Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney.

1980 • 281 citations

Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology.

1977 • 273 citations

Extracellular matrix promotes mammary epithelial growth and differentiation in vitro.

1982 • 262 citations

[45] Proteoglycans: Isolation and Characterization

1982 • 261 citations

The keratinocyte as differentiated cell type.

1980 • 260 citations

Collagen and Embryonic Development

1981 • 250 citations

[1] Collagen: An overview

1982 • 241 citations

Epidermal cells adhere preferentially to type IV (basement membrane) collagen.

1979 • 240 citations

Fibronectin and Its Relation to Cellular Structure and Behavior

1981 • 223 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Respective roles of laminin and fibronectin in adhesion of human carcinoma and sarcoma cells

1981 • 218 citations

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

1981 • 208 citations

New method for preparing large surfaces of intact human basement membrane for tumor invasion studies

1980 • 207 citations

Basal lamina of embryonic salivary epithelia. Nature of glycosaminoglycan and organization of extracellular materials.

1977 • 203 citations

Loss of anionic sites from the glomerular basement membrane in aminonucleoside nephrosis.

1978 • 199 citations

The turnover of basal lamina glycosaminoglycan correlates with epithelial morphogenesis

1982 • 187 citations

The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis

1981 • 182 citations

The production and localization of laminin in cultured vascular and corneal endothelial cells

1981 • 177 citations

Ectoderm — mesoderm relationship in the development of the chick embryo limb bud

1955 • 176 citations

The Extracellular Matrix of the Liver

1982 • 173 citations

The Cancer Cell: Dynamic Aspects and Modifications in Cell-Surface Organization

1976 • 161 citations

Formation of a supramolecular complex is involved in the reconstitution of basement membrane components

1983 • 159 citations

Degradation of Basement Membrane by Murine Tumor Cells2

1977 • 156 citations

Proteoglycans

1981 • 151 citations

Growth factors adherent to cell substrate are mitogenically active in situ

1982 • 141 citations

Isolation and characterization of pepsin fragments of laminin from human placental and renal basement membranes

1981 • 136 citations

The extracellular matrix and the control of proliferation of vascular endothelial and vascular smooth muscle cells

1980 • 129 citations

Cultured sympathetic neurons: Effects of cell-derived and synthetic substrata on survival and development

1980 • 124 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Retrodifferentiation and the Fetal Patterns of Gene Expression in Cancer

1979 • 117 citations

Fibronectin and Other Structural Proteins

1981 • 116 citations

Type I collagen reduces the degradation of basal lamina proteoglycan by mammary epithelial cells.

1981 • 114 citations

Isolation and characterization of proteoglycans synthesized by human colon and colon carcinoma.

1982 • 107 citations

Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor

1982 • 106 citations

Tissue interactions between epithelium and mesenchyme of urogenital and integumental origin

1972 • 105 citations

Glycolipids: Receptors for fibronectin?

1981 • 102 citations

Do plasma and serum have different abilities to promote cell growth?

1980 • 102 citations

SUBSTRATE AND NUTRIENT EFFECTS UPON EPIDERMAL BASAL CELL ORIENTATION AND PROLIFERATION

1964 • 100 citations

Interactions between chondroitin sulfate proteoglycan, fibronectin, and collagen.

1982 • 100 citations

Neurite outgrowth induced by the substrate associated material from nonneuronal cells

1980 • 100 citations

Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes

1976 • 95 citations

Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes.

1978 • 90 citations

The isolation and partial characterization of chondronectin, an attachment factor for chondrocytes.

1982 • 90 citations

Characterization of collagens synthesized by cultured bovine corneal endothelial cells.

1981 • 89 citations

Surfaces of Normal and Malignant Cells

1980 • 86 citations

Inhibition of collagen degradative enzymes by retinoic acid in vitro

1982 • 82 citations

Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata.

1983 • 79 citations

An Essay on Biological Degradation of Collagen

1981 • 76 citations

LONG‐TERM CULTURES OF NORMAL RAT HEPATOCYTES ON LIVER BIOMATRIX

1980 • 72 citations

Extracellular bone matrix-derived growth factor

1982 • 69 citations

[21] New Techniques for Culturing Differential Cells: Reconstituted basement membrane rafts

1979 • 65 citations

The coating of bovine and rabbit corneas denuded of their endothelium with bovine corneal endothelial cells

1979 • 64 citations

Effect of substrata and fibroblast growth factor on the proliferation in vitro of bovine aortic endothelial cells

1981 • 55 citations

Structural and Contractile Proteins

1975 • 48 citations

A new protein that gels F actin in the cell cortex of Dictyostelium discoideum

1981 • 45 citations

Endothelial cell culture on fibrillar collagen: model to study platelet adhesion and liposome targeting to intercellular collagen matrix.

1981 • 44 citations

Patterns of Cellular Peptide Synthesis by Cultured Bovine Granulosa Cells*

1980 • 44 citations

[30] Elastin structure and biosynthesis: An overview

1982 • 43 citations

Tumor extracellular matrix.

1982 • 42 citations

Collagen

1981 • 39 citations

Immunological Characterization of the 7-S Domain of Type IV Collagens

1981 • 38 citations

REGULATION OF GROWTH AND DIFFERENTIATION OF EPITHELIAL CELLS BY HORMONES, GROWTH FACTORS, AND SUBSTRATES OF EXTRACELLULAR MATRIX*

1981 • 37 citations

Cell interactions and development : molecular mechanisms

1983 • 37 citations

The origin of pattern and feather germ tract specificity

1957 • 35 citations

Type V Collagens of the Human Placenta: Trimer α-Chain Composition, Ultrastructural Morphology and Peptide Analysis

1982 • 35 citations

Changes in proliferative activity as cells move along undulating basement membranes in stratified squamous epithelium

1980 • 31 citations

Transporting Renal Epithelium: Culture in Hormonally Defined Serum-Free Medium

1980 • 29 citations

Microfilament-Membrane Interactions in Cell Shape and Surface Architecture

1981 • 28 citations

Transplantation of mouse mammary epithelial cells grown in primary collagen gel cultures.

1982 • 27 citations

Effects of Laminin, Fibronectin and Type IV Collagen on Liver Cell Cultures

1983 • 26 citations

Proteoglycan Biosynthesis

1981 • 24 citations

Collagen Biosynthesis

1981 • 24 citations

Reciprocal interactions between the actin lattice and cell membrane.

1981 • 23 citations

Regulation of local differentiation of cartilage and bone by extracellular matrix: a cascade type mechanism.

1982 • 22 citations

T cell-dependent IgA anti-polysaccharide response in vitro

1981 • 21 citations

Influence of glycosaminoglycans on endogenous DNA synthesis in isolated normal and cancer cell nuclei. Differential effect of heparin

1982 • 20 citations

REGULATION OF GROWTH AND DIFFERENTIATION OF MAMMALIAN CELLS BY HORMONES AND EXTRACELLULAR MATRIX

1982 • 19 citations

A noncollagenous matrix for attachment of rat hepatocytes in culture

1981 • 19 citations

Chloroplast-cytoplasmic interrelations involved in chloroplast development in Chlamydomonas reinhardi y-1: effect of selective depletion of chloroplast translates.

1980 • 18 citations

Plasminogen activator synthesis accompanying chemical carcinogen‐induced in vitro transformation of syrian hamster and guinea‐pig fetal cells

1980 • 16 citations

The effect of different collagen types used as substrata on myogenesis in tissue culture

1980 • 16 citations

GROWTH AND DIFFERENTIATION OF RAT MAMMARY EPITHELIUM ON MAMMARY GLAND EXTRACELLULAR MATRIX11This work was supported by grants BC-357 from the American Cancer Society and HD 16721 from the National Institutes of Health.

1982 • 16 citations

Molecular aspects of control in epidermal differentiation

1976 • 16 citations

Effect of ascorbic acid on the resistance of the extracellular matrix to hydrolysis by tumor cells.

1980 • 15 citations

Current Research with Organ Cultures of Human Tumors

1975 • 13 citations

Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation.

1979 • 12 citations

Role of cell--cell interaction in normal and abnormal erythropoiesis.

1980 • 11 citations

Influence of extracellular matrix on the proliferation of human amniotic fluid cells in vitro

1982 • 10 citations

Interaction of human carcinoma cells with an epithelial layer and the underlying basement membrane. A new model.

1981 • 10 citations

[Reorganisation of thyroid follicular cells in culture. Effect of collagen on the orientation of cell polarity].

1980 • 8 citations

Isolation and characterization of the proteoglycans and collagens synthesized by cells in culture

1981 • 4 citations

[27] Biosynthetic matrices from cells in culture

1982 • 2 citations

Insulin regulates the fibronectin mediated collagenous matrix-cell interaction

1980 • 2 citations

Chemical Characterization and Functional Role of Human Glomerular Basement Membrane Components

1981 • 1 citations