Power to detect linkage with heterogeneity in samples of small nuclear families

Sequential tests for the detection of linkage.

1955 • 1,590 citations

Analysis of Human Genetic Linkage

1992 • 555 citations

Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

1990 • 398 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

Testing for heterogeneity of recombination fraction values in Human Genetics

1963 • 303 citations

Genetic linkage and complex diseases, with special reference to psychiatric disorders

1990 • 283 citations

The transmission of schizophrenia under a multifactorial threshold model.

1983 • 256 citations

Estimating the power of a proposed linkage study for a complex genetic trait.

1989 • 236 citations

Model Misspecification and Multipoint Linkage Analysis

1992 • 195 citations

Genome analysis, a practical approach

1989 • 183 citations

Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms.

1986 • 177 citations

Genetic epidemiology of coronary heart disease. Past, present, and future.

1984 • 140 citations

The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.

1983 • 124 citations

Adequacy of single‐locus approximations for linkage analyses of oligogenic traits

1992 • 107 citations

Analysis of human genetic linkage, revised edition

1993 • 105 citations

Two‐Locus models of disease

1992 • 101 citations

Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data.

1986 • 85 citations

Distribution of the admixture test for the detection of linkage under heterogeneity

1993 • 75 citations

Linkage analysis under “random” and “genetic” reduced penetrance

1989 • 70 citations

Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods.

1992 • 66 citations

Counting methods (EM algorithm) in human pedigree analysis: Linkage and segregation analysis

1977 • 63 citations

Genetic Linkage in Mental Illness

1990 • 60 citations

Defining the Schizophrenia Spectrum: Issues for Genetic Linkage Studies

1991 • 59 citations

Power of the affected‐sib‐pair method for heterogeneous disorders

1988 • 47 citations

Linkage detection tests under heterogeneity

1989 • 44 citations

Detection of linkage under heterogeneity: Comparison of the two‐locus vs. admixture models

1992 • 43 citations

The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci.

1989 • 42 citations

Power of the linkage test for a heterogeneous disorder due to two independent inherited causes: A simulation study

1990 • 34 citations

Genetic linkage and complex diseases: A comment

1990 • 32 citations

Linkage studies of schizophrenia: A simulation study of statistical power

1992 • 31 citations

A new test for linkage in the presence of locus heterogeneity.

1992 • 28 citations

Power and robustness of the linkage homogeneity test in genetic analysis of common disorders

1987 • 23 citations

Sample-size considerations and strategies for linkage analysis in autosomal recessive disorders.

1986 • 13 citations

Detection of linkage for heterogeneous disorders by using multipoint linkage analysis.

1991 • 11 citations

Sampling strategy in linkage studies of affective disorders

1990 • 10 citations

The impact of RFLPs on human gene mapping.

1984 • 9 citations

Genetic Analysis Workshop 6: Linkage analysis based on affected pedigree members.

1989 • 7 citations

Research design considerations for linkage studies of affective disorders using recombinant DNA markers

1987 • 5 citations

Linkage information in small family structures

1993 • 4 citations