Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Transection of the oesophagus for bleeding oesophageal varices

1973 • 7,698 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of Liver

1962 • 909 citations

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

1973 • 504 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

[39] Direct fluorometric methods for measuring mexed-function oxidase activity

1978 • 362 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1990 • 240 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

[11] Radioiodination of proteins by the use of the chloramine-T method

1980 • 225 citations

P450 Enzymes

1992 • 181 citations

Determinants of serum antipyrine half-lives in patients with liver disease

1973 • 178 citations

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

1989 • 154 citations

Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.

1980 • 152 citations

Determinants of Drug Disposition in Patients with Cirrhosis

1983 • 134 citations

Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes

1979 • 133 citations

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1992 • 132 citations

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.

1987 • 130 citations

Mechanism for reduced drug clearance in patients with cirrhosis

1978 • 128 citations

Predictors of one-year pretransplant survival in patients with cirrhosis

1991 • 120 citations

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.

1988 • 110 citations

Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

1986 • 103 citations

Diseases of the liver and biliary tract

1992 • 83 citations

Drug metabolism in cirrhosis

1986 • 77 citations

Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats

1983 • 69 citations

Assessment of lidocaine metabolite formation as a quantitative liver function test in children

1990 • 64 citations

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.

1987 • 61 citations

RATE OF METABOLISM OF TOLBUTAMIDE IN TEST SUBJECTS WITH LIVER DISEASE OR WITH IMPAIRED RENAL FUNCTION

1964 • 57 citations

Hexobarbital disposition in compensated and decompensated cirrhosis of the liver

1978 • 46 citations

Impaired androgen 16α-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats

1987 • 42 citations

Drug metabolism in end-stage liver disease

1990 • 41 citations

Liver size and indices of drug metabolism in alcoholics

1978 • 37 citations

Diseases of the liver and biliary tract.

1994 • 34 citations

Distribution of cytochromes P-450, cytochrome b5, and nadph-cytochrome P-450 reductase in an entire human liver

1990 • 34 citations

Altered regulation of cytochrome P-450 enzymes in choline-deficient cirrhotic male rat liver: impaired regulation and activity of the male-specific androst-4-ene-3,17-dione 16 alpha-hydroxylase, cytochrome P-450UT-A, in hepatic cirrhosis.

1987 • 33 citations

Portal vein ligation selectively lowers hepatic cytochrome P450 levels in rats

1983 • 32 citations

Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline.

1992 • 32 citations

Role of human hepatic cytochromes P450 in drug metabolism and toxicity

1991 • 25 citations

Pharmacokinetics of Nifedipine After Oral Administration in Chronic Liver Disease

1987 • 20 citations