Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets

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1998 • 1,786 citations

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1992 • 883 citations

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Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

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1996 • 603 citations

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

2001 • 232 citations

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APP Transgenic Mice Tg2576 Accumulate Aβ Peptides That Are Distinct from the Chemically Modified and Insoluble Peptides Deposited in Alzheimer's Disease Senile Plaques

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2001 • 131 citations

The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation

2001 • 129 citations

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2002 • 123 citations

The C‐terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome‐dependent mechanism distinct from γ‐secretase

2001 • 120 citations

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

1991 • 105 citations

Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets

1995 • 105 citations

Direct visualization of the gamma secretase‐generated carboxyl‐terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

2002 • 93 citations

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

1999 • 88 citations

Identification of Amino-Terminally and Phosphotyrosine-Modified Carboxy-Terminal Fragments of the Amyloid Precursor Protein in Alzheimer's Disease and Down's Syndrome Brain

2001 • 76 citations

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

1995 • 76 citations

Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP‐CTFs), associated with tau pathology stages, in Alzheimer's disease

2002 • 67 citations

Protease nexin-2/amyloid β-protein precursor in blood is a platelet-specific protein

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Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein

1998 • 32 citations

Identification of the Presenilins in Hematopoietic Cells with Localization of Presenilin 1 to Neutrophil and Platelet Granules

2002 • 23 citations

Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Aβ protein

2002 • 20 citations

Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.

1996 • 20 citations

The Role of the Carboxyl‐Terminal Fragments of Amyloid Precursor Protein in Alzheimer's Disease

2002 • 13 citations

Products of the Alzheimer's disease amyloid precursor protein generated by,β-secretase are present in human platelets, and secreted upon degranulation

1998 • 11 citations

The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer βA4-amyloid precursor protein: Some technical notes

1992 • 10 citations

The Amyloid Protein Precursor of Alzheimer's Disease in Human Platelets and Kidney

1995 • 5 citations

Identification of 5.8 kDa C-terminal fragments of Alzheimer amyloid p protein precursor generated in the lysosomal system

1994 • 3 citations