The role of cytokines and neuroendocrine hormones in cutaneous immunity and inflammation

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Transforming growth factor beta

2011 • 1,990 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor

1992 • 841 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

The cytokine network

1989 • 785 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

The TGF-β family of growth and differentiation factors

1987 • 675 citations

Human monocyte chemoattractant protein-1 (MCP-1)

1990 • 666 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF

1989 • 602 citations

Tumor necrosis factor.

1992 • 601 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Neuroendocrine-Immune Interactions

1993 • 571 citations

CC chemokines in allergic inflammation

1994 • 540 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10.

1992 • 412 citations

Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

2008 • 389 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions.

1991 • 341 citations

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

1994 • 341 citations

Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.

1994 • 330 citations

Expression cloning and characterization of a human IL-10 receptor.

1994 • 327 citations

Recombinant interferon gamma therapy for atopic dermatitis

1993 • 306 citations

Interleukin-12

1994 • 285 citations

Immune Privilege and Immune Regulation in the Eye

1990 • 265 citations

Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing.

1992 • 265 citations

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

1992 • 258 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994 • 232 citations

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

1986 • 221 citations

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.

1993 • 219 citations

IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines.

1989 • 205 citations

Interleukin 7 is produced by murine and human keratinocytes.

1993 • 198 citations

The IL-2/IL-2 receptor system: a target for rational immune intervention

1993 • 194 citations

Interleukin‐9 potentiates the interleukin‐4‐induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes

1993 • 189 citations

Human IL-10 is a chemoattractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration.

1993 • 184 citations

In Vivo Effects of Interleukin-10 on Contact Hypersensitivity and Delayed-Type Hypersensitivity Reactions

1994 • 158 citations

IFN-beta 2/IL-6 augments the activity of human natural killer cells.

1989 • 150 citations

MCP-1 mRNA Expression in Basal Keratinocytes of Psoriatic Lesions

1993 • 150 citations

Interleukin-6: Molecular Pathophysiology

1990 • 146 citations

Interleukin 7: effects on early events in lymphopoiesis

1989 • 140 citations

Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

1994 • 131 citations

Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures.

1992 • 131 citations

Epidermal Growth Factors and Cytokines

1993 • 125 citations

Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.

1993 • 106 citations

Langerhans Cells Are the Major Source of mRNA for IL-1β and MIP-1α Among Unstimulated Mouse Epidermal Cells

1992 • 105 citations

Inhibition of the Induction of Contact Hypersensitivity by a UV-Mediated Epidermal Cytokine

1986 • 103 citations

Neuropeptide regulation of inflammatory and immunologic responses. The capacity of alpha-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1-inducible biologic responses.

1988 • 103 citations

Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-gamma.

1991 • 102 citations

Immune surveillance and sunlight-induced skin cancer

1994 • 102 citations

The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene

1993 • 93 citations

The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation.

1993 • 93 citations

Mechanisms of depressed reactivity to dinitrochlorobenzene and ultraviolet-induced tumors during ultraviolet carcinogenesis in BALB/c mice

1978 • 88 citations

Functional and biochemical characterization of mouse P40/IL-9 receptors.

1990 • 87 citations

Alpha-Melanocyte Stimulating Hormone Modulates Contact Hypersensitivity Responsiveness in C57/BL6 Mice

1989 • 82 citations

Cytokine Modulation of Pituitary Hormone Secretiona

1990 • 74 citations

Interleukin 6 inhibits delayed‐type hypersensitivity and the development of adjuvant arthritis

1991 • 68 citations

FcϵRI on human Langerhans cells: a receptor in search of new functions

1994 • 66 citations

Human cutaneous allergic late-phase response is inhibited by soluble IL-1 receptor.

1994 • 63 citations

Neuropeptides and immunopeptides: Messengers in a neuroimmune axis

1989 • 60 citations

Production of Immunosuppressing Melanotropins By Human Keratinocytes^a

1993 • 59 citations

Pentoxifylline Suppresses Irritant and Contact Hypersensitivity Reactions

1993 • 57 citations

The cloning and biological characterization of recombinant human interleukin 11

1992 • 48 citations

The biology of interleukin 11

1996 • 46 citations

Interleukin 1α but Not Transforming Growth Factor β Inhibits Tumor Antigen Presentation by Epidermal Antigen-Presenting Cells

1994 • 35 citations

Interleukin-9

1993 • 35 citations

Enhancement of the Elicitation Phase of the Murine Contact Hypersensitivity Response by Prior Exposure to Local Ultraviolet Radiation

1986 • 33 citations

Interleukin-7: Biology and Potential Clinical Applications

1993 • 31 citations

Mechanisms of Ultraviolet Radiation Carcinogenesis

1994 • 22 citations

Regulation of Interleukin 4 Production and of Interleukin 4-Producing Cells

1992 • 17 citations

Structure and function of IL-2 and IL-2 receptors.

1992 • 13 citations

Immunophysiology — The Role of Cells and Cytokines in Immunity and inflammation

1991 • 11 citations

Interleukin 2-Like Material in Human Epidermis: A Ligand for the Human Interleukin 2-Receptor 55 kD Alpha Chain

1989 • 11 citations

[IgE receptors in Langerhans cells. A link between the environment and the immune system?].

1992 • 7 citations

Detection of the production of interleukin (IL) 12 by human keratinocytes

1994 • 2 citations