New Drosophila introns originate by duplication

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox

1978 • 681 citations

Genes in pieces: were they ever together?

1978 • 440 citations

The Exon Theory of Genes

1987 • 395 citations

Splicing signals inDrosophila: intron size, information content, and consensus sequences

1992 • 380 citations

Implications of RNA⋅RNA Splicing in Evolution of Eukaryotic Cells

1978 • 333 citations

On the antiquity of introns

1986 • 324 citations

Pseudogenes in yeast?

1987 • 316 citations

A phylogenetic, revised classification of genera in the Drosophilidae (Diptera).

1990 • 275 citations

The recent origins of introns

1991 • 263 citations

Origin of Genes

1997 • 236 citations

Testing the Exon Theory of Genes: The Evidence from Protein Structure

1994 • 217 citations

Intron “sliding” and the diversity of intron positions

1997 • 156 citations

Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): Structural analysis of the protein and chromosomal location of the gene

1993 • 146 citations

Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory.

1995 • 134 citations

The gene for the U6 small nuclear RNA in fission yeast has an intron

1989 • 126 citations

Sequence of the Structural Gene for Xanthine Dehydrogenase (rosy Locus) in Drosophila melanogaster

1987 • 115 citations

Drosophila Molecular Phylogenies and Their Uses

1995 • 106 citations

mRNA-type introns in U6 small nuclear RNA genes: implications for the catalysis in pre-mRNA splicing.

1991 • 96 citations

Mutations Affecting Expression of the rosy Locus in Drosophila melanogaster

1987 • 89 citations

Cloning and Molecular Characterization of hxA, the Gene Coding for the Xanthine Dehydrogenase (Purine Hydroxylase I) of Aspergillus nidulans

1995 • 89 citations

Exon/intron structure of aldehyde dehydrogenase genes supports the “ introns-late ” theory

1997 • 69 citations

Protein Evolution by Exon-Shuffling

1995 • 53 citations

Divergence of the nucleotide sequences encoding xanthine dehydrogenase in Calliphora vicina and Drosophila melanogaster

1989 • 48 citations

Evidence against the exon theory of genes derived from the triose-phosphate isomerase gene.

1995 • 46 citations

Structure and sequence of the Cu,Zn Sod gene in the Mediterranean fruit fly, Ceratitis capitata: Intron insertion/deletion and evolution of the gene

1992 • 37 citations

An mRNA-Type Intron Is Present in the Rhodotorula hasegawae U2 Small Nuclear RNA Gene

1993 • 22 citations

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